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    Liquid mixing and transfer apparatus and method
    2.
    发明授权
    Liquid mixing and transfer apparatus and method 失效
    液体混合和转移装置及方法

    公开(公告)号：US3588053A

    公开(公告)日：1971-06-28

    申请号：US3588053D

    申请日：1967-12-20

    Applicant: COULTER ELECTRONICS

    Inventor： ROTHERMEL WILLIAM FLETCHER

    IPC: B01F15/04 ,  B01F5/00 ,  G01N1/00 ,  G01N1/38 ,  G01N33/48 ,  G01N35/10

    CPC classification number: G01N1/38 ,  B01F5/0057 ,  G01N35/1095

    Abstract: APPARATUS COMPRISING AT LEAST ONE VESSEL INTO WHICH LIQUIDS ARE INTRODUCED, MIXED AND DRAINED WITHOUT THE USE OF ANY MECHANICAL MIXING DEVICE, WITHOUT CONTAMINATION AND WITHOUT AGITATION TO AN EXTENT THAT SLOW-RISING OR PERSISTENT BUBBLES WILL NOT FORM. SUCH APPARATUS IS ADPATED FOR CONNECTION INTO A SYSTEM FOR THE CONTINUOUS AUTOMATIC PROCESSING OF SAMPLES. THE APPARATUS COMPRISE A SINGLE OR PLURALTIY OF VESSELS PERFORMING THE FUNCTIONS MENTIONED AND HAVE A FITTING AT LEAST IN ONE VESSEL ARRANGED TO INTRODUCE THE LIQUIDS TANGENTIAL TO THE INNER WALL OF THE RECEIVING VESSEL TO PRODUCE A HELICAL DOWNWARD SWIRLING OF THE LIQUID TO IMPART ROTARY MOTION THERETO. AT THE SAME TIME, AT LEAST IN SINGLE VESSELS, AN UPAND-DOWN MOVEMENT OF THE LIQUID IS PRODUCED BY THE INTRODUCTION OF A GAS INTO THE DRAIN AND GENERATES FAST-RISING BUBBLES PASSING THROUGH THE LIQUID THROROUGHLY TO MIX THE SAME IN THE VESSEL. ALTERNATE MEANS FOR USE IN MULTIPLE VESSEL APPARATUS PROVIDE FOR INTERCHANGE OR TRANSFER OF LIQUIDS AT THE BOTTOM OF THE VESSELS TO EFFECT THE UP-AND-DOWN MIXING AS WELL AS ROTATION OF THE LIQUID. STRUCTURE FOR RETAINING LIQUID IN THE VESSELS BY THE USE OF GAS INTRODUCED THROUGH A DRAIN, FOR EFFECTING LIQUID REMOVAL BY GAS PRESSURE CONTROLLED TO PROVIDE MINIMUM AGITATION; AND FOR OTHER PURPOSES ARE DISCLOSED. METHODS FOR MIXING AND TRANSFERRING LIQUIDS ARE DESCRIBED IN CONNECTION WITH THE APPARATUS OF THE INVENTION, ESPECIALLY A METHOD OF EXPELLING LIQUID FROM A VESSEL BY THE USE OF GAS PRESSURE ABOVE THE SURFACE OF THE LIQUID IN WHICH THE AMOUNT OF PRESSURE DECREASES WITH THE LOWERING OF THE LEVEL.

    3.
    发明专利
    未知

    公开(公告)号：IT8448957D0

    公开(公告)日：1984-10-05

    申请号：IT4895784

    申请日：1984-10-05

    Applicant: COULTER ELECTRONICS

    Inventor： COULTER WALLACE HENRY ,  ROTHERMEL WILLIAM FLETCHER

    IPC: G01N33/48 ,  G01N1/00 ,  G01N1/10 ,  G01N33/483 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B25J

    Abstract: A plurality of sealed blood sample tubes are housed in a rack and a plurality of these racks are vertically stacked, with the sample tubes lying horizontally. The racks are successively deposited onto a horizontal conveyor belt which is housed in and moves longitudinally on a table that rocks around its longitudinal axis to mix the samples in a semi-inverting mode as a rack is stepped from the stack to a sample aspiration station and/or thereat. The aspiration station preferably includes a sample segmenting and diluting valve and a sample identification reader. Aspiration is accomplished by pushing a sample tube partially out from the carrier rack and onto a seal piercing tip of the aspiration probe. The tube then is returned to the rack. The other tubes in that rack similarly are aspirated after the rack is stepped to align each tube with the aspiration probe, with table rocking and sampling mixing accompanying each advancing step of the rack. After a rack has advanced through the aspiration station, it is stacked out of the way.

    4.
    发明专利
    未知

    公开(公告)号：IT1178027B

    公开(公告)日：1987-09-03

    申请号：IT4895784

    申请日：1984-10-05

    Applicant: COULTER ELECTRONICS

    Inventor： COULTER WALLACE HENRY ,  ROTHERMEL WILLIAM FLETCHER

    IPC: G01N33/48 ,  G01N1/00 ,  G01N1/10 ,  G01N33/483 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B25J

    Abstract: A plurality of sealed blood sample tubes are housed in a rack and a plurality of these racks are vertically stacked, with the sample tubes lying horizontally. The racks are successively deposited onto a horizontal conveyor belt which is housed in and moves longitudinally on a table that rocks around its longitudinal axis to mix the samples in a semi-inverting mode as a rack is stepped from the stack to a sample aspiration station and/or thereat. The aspiration station preferably includes a sample segmenting and diluting valve and a sample identification reader. Aspiration is accomplished by pushing a sample tube partially out from the carrier rack and onto a seal piercing tip of the aspiration probe. The tube then is returned to the rack. The other tubes in that rack similarly are aspirated after the rack is stepped to align each tube with the aspiration probe, with table rocking and sampling mixing accompanying each advancing step of the rack. After a rack has advanced through the aspiration station, it is stacked out of the way.

    FLUID TRANSFER VALVE STRUCTURE
    8.
    发明专利
    FLUID TRANSFER VALVE STRUCTURE 未知

    公开(公告)号：GB1268937A

    公开(公告)日：1972-03-29

    申请号：GB1681169

    申请日：1969-03-31

    Applicant: COULTER ELECTRONICS

    Inventor： COULTER WALLACE HENRY ,  ROTHERMEL WILLIAM FLETCHER

    IPC: F16K3/10 ,  B01L99/00 ,  F16K11/074 ,  F16K11/076 ,  G01N1/38 ,  G05D11/00 ,  G05D11/13

    Abstract: 1,268,937. Proportioning mixture components; sampling valve. COULTER ELECTRONICS Ltd. 31 March, 1969 [3 April, 1968], No. 16811/69. Headings B1C and B1X. [Also in Divisions B8 and F2] Apparatus for separating and diluting a measured sample of liquid comprises a valve 10, having two fixed sections 12, 16 each with four ports P1-P4 and P5-P8 respectively and a central rotatable section 14 with two passages P9; P10 which can alternately connect two pairs of diagonally opposite ports, the three sections 12, 14, 16 being biassed together, but the biassing being partially relieved during rotation of the section 14. Operation. When the passage P9 is aligned with ports P1, P5, as shown in Fig. 2, liquid to be sampled is drawn from a vessel 36 through a three-way valve 22 by a pistonoperated pump 56 so that the passage P9 contains a sample. The section 14 is then rotated to align the passage P9 with ports P2, P6 and a further three-way valve 26 is operated to dispense a measured volume of the diluting liquid, pumped by one stroke of a further piston operated pump 62 from a vessel 72 into a line 24 and along with the sample in the passage P9, into the container 44, from which part of the sample may be run off and tested. The diluted sample in the container 44 may be further diluted by a similar process, that is, raising the diluted sample into the passage P10, now aligned with ports P4, P8, by the pump 56 and three-way valve 22, then rotating the section 14 to align the passage P10 with ports P3, P7 so that the volume of diluted sample contained in the passage P10 may be further diluted with a measured volume of diluting liquid and transferred to a container 50 for testing. Construction. The three valve sections 12, 14, 16 are held on a spindle 300, rotatably mounted on a plate 302, by a bolt 312. The spindle 300 is rotated by an arm 326, connected by a universal joint 329 to a piston reciprocating at right angles to the plane of Fig. 6, thus causing the section 14 to rotate, as this section has a rectangular axial hole corresponding to a rectangular sectioned portion 304 of the spindle 300. A rod 306 engages with grooves 310 in the sections 12, 16 preventing their rotation and with shoulders 314 on the section 14 to limit its rotation. The bolt 312 screws into a piston 334 which is biassed away from the plate 302 both by a spring 338 and by a diaphragm 356 acted on by compressed air introduced through an inlet 358 and abutting a plate 348 fixed to the piston. This biassing prevents leakage between the sections 12, 14, 16 when stationary; however, when it is required to move the section 14, a servo mechanism (not shown) relieves the compressed air acting on the diaphragm so that only the spring 338 biasses the sections together thus reducing the wear. Movement of the piston 334 is limited by a pin 344 moving within a groove 343.

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