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公开(公告)号：DE2449321A1
公开(公告)日：1975-04-30
申请号：DE2449321
申请日：1974-10-16
Applicant: COULTER ELECTRONICS
Inventor： COULTER WALLACE HENRY , HOGG WALTER ROBERT , DOTY EDWARD NEAL , LONGMAN JUN MILLARD DUMAS , CAMPBELL STEPHEN KENNEDY
Abstract: A method and apparatus for correcting a particle pulse count subject to coincidence error is disclosed wherein particle pulses, developed in response to passage of particles in a particulate system through a sensing zone, are counted for a predetermined period of time. The predetermined period of time is increased or extended in response to each pulse counted by a time increment that is a function of a characteristic of the counted pulse, such as the pulse width, duration, or amplitude. The total additional time period allows the counting of additional particle pulses such that the total count at the end of the extended time period is an error corrected count for the number of particles detected in the predetermined time period.
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公开(公告)号：DE2323372A1
公开(公告)日：1973-11-29
申请号：DE2323372
申请日：1973-05-09
Applicant: COULTER ELECTRONICS
Inventor： HOGG WALTER ROBERT , COULTER WALLACE HENRY
Abstract: To clamp a train of electric pulses in a system having a small signal-to-noise ratio, the point in the circuit to be clamped is arranged such that the d.c. level appears at the output thereof, is filtered therefrom and fed back to the input of the clamped stage, where it is subtracted out. The feedback path is broken if the output exceeds a predetermined value.
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公开(公告)号：GB903156A
公开(公告)日：1962-08-15
申请号：GB1884759
申请日：1959-06-02
Applicant: COULTER ELECTRONICS
Inventor： JR JOSEPH RICHARD COULTER , COULTER WALLACE HENRY
IPC: G01N15/12
Abstract: 903,156. Electric selective-signalling systems. COULTER ELECTRONICS Ltd. June 2, 1959, No. 18847/59. Class 40 (1). [Also in Groups XXVIII and XXXVI] Apparatus for detecting particles suspended in a fluid medium comprises a hollow body having an orifice submerged in a vessel and having a solid member engaged with the fluid in the hollow body to provide fluid flow through the orifice in a volume related to the displacement of the member and means operated by the displaced member to initiate the detection of particles. Fig. 1 shows a beaker 34 containing the liquid under test in which is submerged an orifice 42 in a tube 38 also containing the test liquid. The piston 76 is first displaced in an upward direction under control of the vacuum control valve 66. When valve 66 is closed the weight 92 will operate a rack and pinion 80, 86, withdrawing the piston 76 and causing a flow of test liquid through the orifice 42. When a particle passes through the orifice 42 a change in liquid conductivity is observed by the detector 10, which supplies a constant current or constant voltage to electrodes 58, 60. A switch 98 is operated by projection 96 to initiate the start of a countercontained in apparatus 10. The counter is stopped by projection 96, engaging switch 100 after a predetermined quantity of liquid has passed through the orifice. In Fig. 2 (not shown), the projection 96 is replaced by a contact on the piston, engaging contacts let in to the wall of tube 74. Fig. 6 (not shown), relates to an embodiment for metering very small volumes of liquid. The piston is formed by a thin rod passing through a seal located in tube 74. Fig. 5 shows an arrangement for testing corrosive liquids in which a flexible diaphragm is interposed between the test liquid 56 and the metering pump contained in tube 186. The piston 188 is lowered under the control of vacuum control valve 194. When valve 194 is closed the piston 188 is raised by motor 210 drawing the tested fluid through the orifice. Modifications.-The vacuum valve 66 may be controlled automatically by the start/stop signals. Suction or pressure may be applied to the tested fluid and the piston 76 used only as a passive metering device. Locating conductive pistons.-In Fig. 7 a solid metallic piston 230 may be used, start and stop indications being respectively provided as the piston passes between the pairs of electrodes 222, 224 and 226, 228, thus varying the capacitive coupling or frequency of oscillators 160, 164. In Fig. 3, the start and stop indications are provided as conductive loops 150 pass between pairs of coils 152, 154 and 156, 158. The coils of each pair are connected respectively in the anode and grid circuits of an oscillator so that oscillation is only commenced in the presence of the conductive loop 150. Fig. 4 (not shown), relates to coil construction.
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公开(公告)号：DE2314578A1
公开(公告)日：1973-10-11
申请号：DE2314578
申请日：1973-03-23
Applicant: COULTER ELECTRONICS
Inventor： COULTER WALLACE HENRY , HOGG WALTER ROBERT , BADER HENRI
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公开(公告)号：GB1268937A
公开(公告)日：1972-03-29
申请号：GB1681169
申请日：1969-03-31
Applicant: COULTER ELECTRONICS
Inventor： COULTER WALLACE HENRY , ROTHERMEL WILLIAM FLETCHER
IPC: F16K3/10 , B01L99/00 , F16K11/074 , F16K11/076 , G01N1/38 , G05D11/00 , G05D11/13
Abstract: 1,268,937. Proportioning mixture components; sampling valve. COULTER ELECTRONICS Ltd. 31 March, 1969 [3 April, 1968], No. 16811/69. Headings B1C and B1X. [Also in Divisions B8 and F2] Apparatus for separating and diluting a measured sample of liquid comprises a valve 10, having two fixed sections 12, 16 each with four ports P1-P4 and P5-P8 respectively and a central rotatable section 14 with two passages P9; P10 which can alternately connect two pairs of diagonally opposite ports, the three sections 12, 14, 16 being biassed together, but the biassing being partially relieved during rotation of the section 14. Operation. When the passage P9 is aligned with ports P1, P5, as shown in Fig. 2, liquid to be sampled is drawn from a vessel 36 through a three-way valve 22 by a pistonoperated pump 56 so that the passage P9 contains a sample. The section 14 is then rotated to align the passage P9 with ports P2, P6 and a further three-way valve 26 is operated to dispense a measured volume of the diluting liquid, pumped by one stroke of a further piston operated pump 62 from a vessel 72 into a line 24 and along with the sample in the passage P9, into the container 44, from which part of the sample may be run off and tested. The diluted sample in the container 44 may be further diluted by a similar process, that is, raising the diluted sample into the passage P10, now aligned with ports P4, P8, by the pump 56 and three-way valve 22, then rotating the section 14 to align the passage P10 with ports P3, P7 so that the volume of diluted sample contained in the passage P10 may be further diluted with a measured volume of diluting liquid and transferred to a container 50 for testing. Construction. The three valve sections 12, 14, 16 are held on a spindle 300, rotatably mounted on a plate 302, by a bolt 312. The spindle 300 is rotated by an arm 326, connected by a universal joint 329 to a piston reciprocating at right angles to the plane of Fig. 6, thus causing the section 14 to rotate, as this section has a rectangular axial hole corresponding to a rectangular sectioned portion 304 of the spindle 300. A rod 306 engages with grooves 310 in the sections 12, 16 preventing their rotation and with shoulders 314 on the section 14 to limit its rotation. The bolt 312 screws into a piston 334 which is biassed away from the plate 302 both by a spring 338 and by a diaphragm 356 acted on by compressed air introduced through an inlet 358 and abutting a plate 348 fixed to the piston. This biassing prevents leakage between the sections 12, 14, 16 when stationary; however, when it is required to move the section 14, a servo mechanism (not shown) relieves the compressed air acting on the diaphragm so that only the spring 338 biasses the sections together thus reducing the wear. Movement of the piston 334 is limited by a pin 344 moving within a groove 343.
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Patent Agency Ranking
公开(公告)号：DE1598236A1
公开(公告)日：1970-05-06
申请号：DE1598236
申请日：1965-10-12
Applicant: COULTER ELECTRONICS
Inventor： COULTER WALLACE HENRY , TRAFTON MORGAN CHARLES
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公开(公告)号：IT1178027B
公开(公告)日：1987-09-03
申请号：IT4895784
申请日：1984-10-05
Applicant: COULTER ELECTRONICS
Inventor： COULTER WALLACE HENRY , ROTHERMEL WILLIAM FLETCHER
IPC: G01N33/48 , G01N1/00 , G01N1/10 , G01N33/483 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , B25J
Abstract: A plurality of sealed blood sample tubes are housed in a rack and a plurality of these racks are vertically stacked, with the sample tubes lying horizontally. The racks are successively deposited onto a horizontal conveyor belt which is housed in and moves longitudinally on a table that rocks around its longitudinal axis to mix the samples in a semi-inverting mode as a rack is stepped from the stack to a sample aspiration station and/or thereat. The aspiration station preferably includes a sample segmenting and diluting valve and a sample identification reader. Aspiration is accomplished by pushing a sample tube partially out from the carrier rack and onto a seal piercing tip of the aspiration probe. The tube then is returned to the rack. The other tubes in that rack similarly are aspirated after the rack is stepped to align each tube with the aspiration probe, with table rocking and sampling mixing accompanying each advancing step of the rack. After a rack has advanced through the aspiration station, it is stacked out of the way.
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公开(公告)号：DE2539864A1
公开(公告)日：1977-03-10
申请号：DE2539864
申请日：1975-09-08
Applicant: COULTER ELECTRONICS
Inventor： COULTER WALLACE HENRY
Abstract: The particle analysis equipment utilises a detector (15) formed from a membrane, a current source, a manometer, input and output contacts and means for liquid transport. The detector output is connected to an amplifier (16) and thereafter to a differentiator (18) which may be built up from a resistor and a capacitor. The differentiator output has a diode by-pass to earth which abbreviates the positive pulses, so that the trailing pulse flank signal proceeds to a threshold value circuit (22) with level controlled by a potentiometer (24). The final stages are an electronic switch (26) and an amplitude analyser (32). A direct connection (34) exists between the detector (15) and the analyser (32) so that the latter is responsive both to particle amplitude and its differential coefficient.
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公开(公告)号：DE2534955A1
公开(公告)日：1976-02-19
申请号：DE2534955
申请日：1975-08-05
Applicant: COULTER ELECTRONICS
Inventor： HOGG WALTER ROBERT , COULTER WALLACE HENRY
Abstract: An apparatus for determining the correct particle sizes at predetermined percentiles of the size distribution of a particulate system having a known size distribution characteristic such as for example a normal or log-normal size distribution, wherein a portion of the particles are too small to be measured. The particulate system is first passed through a particle detecting device which can be of the Coulter type. The particle detecting device produces particle pulses proportional to the size of the particles in the particulate system which can be measured. At least three percentile size determining circuits receive the particle pulses and develop first, second and third particle size signals respectively, indicating the size of the particles in the particulate system at the first, second and third predetermined percentiles. Two of the size signals are combined in a particular manner based on the known size distribution characteristic for the type of particulate system to yield a combined signal which approximates or is and estimate of the third percentile signal. The combined signal is compared with the measured third signal to obtain an error signal. The error signal is used in turn to add into all three size percentile circuits compensation or correction signals for the total volume of particules too small to be included in the measurements. This process causes the error signal to decrease toward zero, and results in all three circuits having outputs truly representative of their nominal percentiles.
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公开(公告)号：DE2438401A1
公开(公告)日：1975-02-27
申请号：DE2438401
申请日：1974-08-09
Applicant: COULTER ELECTRONICS
Inventor： LIEDHOLZ GERHARD ADOLPH , COULTER WALLACE HENRY , HOGG WALTER ROBERT
Abstract: The electrical sensing circuitry includes a power supply and a signal-detecting circuit which are coupled through the resistance of an electrolyte in a liquid in an aperture of a particle-analyzing device between sensing electrodes positioned on either side of the aperture. The liquid containing an electrolyte and the passage of a liquidborne particle through the aperture causes a change in the resistance of the aperture thereby generating a signal which is detected by the signal-detecting circuit. The parameters of the circuit elements are chosen to provide circuit relationships which render the particle-generated signal independent of the diameter of the aperture. This is achieved by utilizing a power source having a low output impedance and a signal-detecting circuit which has a low input impedance for both D.C. and A.C., namely, at the signal frequencies of the signals sensed. The electrical circuitry also may include a conductivity monitoring circuit which may utilize one or more of the sensing electrodes and/or additional electrodes for monitoring changes in conductivity of the electrolyte and for relating these changes in conductivity to the particle-generated signals sensed by the signal-detecting circuit to alter those signals so as to render them independent of electrolyte resistivity.
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