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    System and Method for Drug Detection Using SWIR
    2.
    发明申请
    System and Method for Drug Detection Using SWIR 审中-公开
    使用SWIR进行药物检测的系统和方法

    公开(公告)号：US20140043488A1

    公开(公告)日：2014-02-13

    申请号：US14055509

    申请日：2013-10-16

    Applicant: ChemImage Corporation

    Inventor： Patrick Treado ,  Matthew Nelson ,  Charles Gardner

    IPC: G01N33/15

    CPC classification number: G01N33/15 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/44 ,  G01N21/359 ,  G01N33/0057

    Abstract: A method for detecting unknown materials, such as drugs. A first location is surveyed using a video capture device to identify a second location comprising an unknown material. The second location is interrogated using SWIR spectroscopic and/or imaging methods to generate a SWIR hyperspectral image. The SWIR hyperspectral image is analyzed to associate the unknown material with a known drug material. A system for detecting unknown materials, such as drugs comprising a first collection lens for collecting interacted photons from a first location and a visible imaging device for generating a visible image. A second collection lens may collect a plurality of interacted photons from a second location and a tunable filter may filter the interacted photons. A spectroscopic imaging device may detect the interacted photons and generate a SWIR hyperspectral image. A processor may analyze the SWIR hypespectral image to associate an unknown material with a known material.

    Abstract translation: 检测未知物质如药物的方法。 使用视频捕获设备来测量第一位置以识别包括未知材料的第二位置。 使用SWIR光谱和/或成像方法询问第二个位置以产生SWIR高光谱图像。 分析SWIR高光谱图像以将未知材料与已知药物材料相关联。 一种用于检测未知材料的系统，例如药物，其包括用于从第一位置收集相互作用的光子的第一收集透镜和用于产生可见图像的可见成像装置。 第二采集透镜可以从第二位置收集多个相互作用的光子，并且可调谐滤光器可以过滤相互作用的光子。 光谱成像装置可以检测相互作用的光子并产生SWIR高光谱图像。 处理器可以分析SWIR超光谱图像以将未知材料与已知材料相关联。

    Molecular chemical imaging endoscopic imaging systems
    3.
    发明授权
    Molecular chemical imaging endoscopic imaging systems 有权

    公开(公告)号：US10779713B2

    公开(公告)日：2020-09-22

    申请号：US15932435

    申请日：2015-12-09

    Applicant: ChemImage Corporation

    Inventor： Patrick Treado ,  Matthew Nelson ,  Shona Stewart

    IPC: A61B1/07 ,  A61B1/04 ,  A61B1/06 ,  A61B1/307 ,  A61B1/00

    Abstract: The instant disclosure provides for medical imaging systems that may be used in conjunction with an intraoperative medical device, such as an endoscope. Generally, the disclosed medical imaging systems include an illumination source configured to generate illuminating photons for illuminating a biological sample. An optical signal modulator is configured to separate one or more of the illuminating photons and photons that have interacted with the biological sample into a first optical signal having first multi-passband wavelengths and a second optical signal having second multi-passband wavelengths. At least one detector is configured to detect one or more of the first optical signal and the second optical signal and generate at least one image data set. A processor is configured to analyze the at least one image data set. In some embodiments, the processor is configured to differentiate between structures of the biological sample, such as between an ureter and surrounding tissue.

    System and method for safer detection of unknown materials using dual polarized hyperspectral imaging and Raman spectroscopy
    5.
    发明授权
    System and method for safer detection of unknown materials using dual polarized hyperspectral imaging and Raman spectroscopy 有权
    使用双偏振高光谱成像和拉曼光谱法更安全地检测未知材料的系统和方法

    公开(公告)号：US08743358B2

    公开(公告)日：2014-06-03

    申请号：US13842098

    申请日：2013-03-15

    Applicant: ChemImage Corporation

    Inventor： Patrick Treado ,  Matthew Nelson ,  Charles Gardner

    IPC: G01J3/28

    CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0221 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/44 ,  G01N21/17 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

    Abstract: A first location comprising an unknown material may be scanned using SWIR hyperspectral imaging in a dual polarization configuration. Surveying may also be applied to thereby determine whether or not a human is present. This surveying may be achieved my assessing LWIR data, data acquired from motion sensors, and combinations thereof. If no human is present, a second location may be interrogated using Raman spectroscopic techniques to thereby obtain a Raman data set representative of the region of interest. This Raman data set may be assessed to associate an unknown material with a known material. This assessment may be achieved by comparing the Raman data set to one or more reference data sets in a reference database, where each reference data set is associated with a known material.

    Abstract translation: 包含未知材料的第一位置可以使用双极化配置中的SWIR高光谱成像进行扫描。 还可以进行测量，从而确定人是否存在。 本次测量可能会实现我对LWIR数据的评估，运动传感器获取的数据及其组合。 如果不存在人，则可以使用拉曼光谱技术询问第二位置，从而获得表示感兴趣区域的拉曼数据集。 可以评估该拉曼数据集以将未知材料与已知材料相关联。 可以通过将拉曼数据集与参考数据库中的一个或多个参考数据集进行比较来实现该评估，其中每个参考数据集与已知材料相关联。

    Targeted Agile Raman System for Detection of Unknown Materials
    6.
    发明申请
    Targeted Agile Raman System for Detection of Unknown Materials 审中-公开
    用于检测未知材料的目标敏捷拉曼系统

    公开(公告)号：US20130114070A1

    公开(公告)日：2013-05-09

    申请号：US13729220

    申请日：2012-12-28

    Applicant: ChemImage Corporation

    Inventor： Charles Gardner, JR. ,  Matthew Nelson

    IPC: G01J3/44

    CPC classification number: G01J3/02 ,  G01J3/0221 ,  G01J3/0264 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/44 ,  G01N21/6456 ,  G01N21/65 ,  G01N33/22 ,  G01N2021/1738 ,  G01N2021/174 ,  G01N2021/1744

    Abstract: The present disclosure provides for a system and method for detecting unknown materials. A test data set, which may comprise a hyperspectral data set, is generated representative of a first location. The test data set may be analyzed to determine a second location which may be interrogated using a Raman spectrocscopic device to generate a Raman data set. The Raman data set may be analyzed to associated an unknown material with a known material such as: a chemical material, a biological material, an explosive material, a hazardous material, a drug material, and combinations thereof.

    Abstract translation: 本公开提供了用于检测未知材料的系统和方法。 产生代表第一位置的测试数据集，其可以包括高光谱数据集。 可以分析测试数据集以确定可以使用拉曼光谱设备询问的第二位置，以产生拉曼数据集。 可以分析拉曼数据集，以将已知材料与未知材料相关联，例如：化学材料，生物材料，爆炸材料，危险材料，药物材料及其组合。

    Systems and methods for discrimination of tissue targets
    8.
    发明授权
    Systems and methods for discrimination of tissue targets 有权

    公开(公告)号：US11598717B2

    公开(公告)日：2023-03-07

    申请号：US17121247

    申请日：2020-12-14

    Applicant: CHEMIMAGE CORPORATION

    Inventor： Alyssa Zrimsek ,  Matthew Nelson ,  Lei Shi ,  Heather Gomer ,  Shawna Tazik

    IPC: G01N21/3563 ,  H04N5/225 ,  A61B90/00 ,  A61B90/30 ,  G01N21/17

    Abstract: Systems for and methods for detecting samples and other compounds of interest are disclosed herein. The system can include an illumination source that is configured to emit light in a variety of different wavelength bands, an optical filter, a camera chip, and an optical path configured to direct the light emitted by the first illumination source at a target and direct the light reflected from the target to the at least one camera chip. The illumination source and the optical filter are transitionable between a first tuning state corresponding to a target tissue and a second tuning state corresponding to a background tissue. The system can be configured to record images at the different tuning states and generate a score image corresponding to the target tissue based on the recorded images.

    Dual polarization with liquid crystal tunable filters
    9.
    发明授权
    Dual polarization with liquid crystal tunable filters 有权
    双极化与液晶可调滤波器

    公开(公告)号：US08988680B2

    公开(公告)日：2015-03-24

    申请号：US13651600

    申请日：2012-10-15

    Applicant: ChemImage Corporation

    Inventor： Matthew Nelson

    IPC: G01J3/28 ,  G01J3/02 ,  G01J3/32 ,  G01J3/44 ,  G01N21/31 ,  G01N21/35 ,  G02B21/00 ,  G02B21/16 ,  G02B21/36 ,  G01N21/21 ,  G01N21/33 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65

    CPC classification number: G01N21/255 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/44 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

    Abstract: A high passband transmission ratio is obtained by splitting a light beam from an objective lens into two orthogonally-polarized components processed along distinct paths through two independently controllable liquid crystal tunable filters (LCTFs). The filtered portions may be combined at an imaging plane or may be separately processed without recombining. Using two LCTFs, the arrangements discussed herein may ideally achieve 100% transmission in a single passband when two orthogonal components of a single wavelength are tuned, or 50% transmission at two distinct passbands when two orthogonal components from two different wavelengths (one component from each wavelength) are tuned. The dual polarization configuration described herein may be used to improve contrast or detected signal intensity in various microscopy and spectroscopic/chemical imaging applications and to increase the speed of detection.

    Abstract translation: 通过将来自物镜的光束分成通过两个独立可控的液晶可调滤波器（LCTF）沿不同路径处理的两个正交极化分量，获得高通带传输比。 过滤部分可以在成像平面处组合，或者可以在不重新组合的情况下分开处理。 使用两个LCTF，当两个不同波长的两个正交分量（来自两个不同波长的一个分量）（两个不同波长的两个正交分量） 波长）调整。 本文描述的双极化配置可用于改善各种显微镜和分光/化学成像应用中的对比度或检测信号强度，并提高检测速度。

    System and method for detecting target materials using a VIS-NIR detector
    10.
    发明授权
    System and method for detecting target materials using a VIS-NIR detector 有权

    公开(公告)号：US10317282B2

    公开(公告)日：2019-06-11

    申请号：US15401716

    申请日：2017-01-09

    Applicant: CHEMIMAGE CORPORATION

    Inventor： Matthew Nelson ,  Patrick Treado ,  Charles Gardner ,  Andrew Basta

    IPC: G01J3/28 ,  H01L27/146 ,  G01N21/31 ,  G01N21/359 ,  A61B5/00 ,  G01J3/02 ,  G01J3/12

    Abstract: The present disclosure provides systems and methods for determining the presence of a target material in a sample. In general terms, the system and method disclosed herein provide collecting interacted photons from a sample having a target material. The interacted photons are passed through a tunable filter to a VIS-NIR detector where the VIS-NIR detector generates a VIS-NIR hyperspectral image representative of the filtered interacted photons. The hyperspectral image of the filtered interacted photons is analyzed by comparing the hyperspectral image of the filtered interacted photons to known hyperspectral images to identify the presence of a target material in a sample. The systems and methods disclosed herein provide easy identification of the presence of a target material in a sample.

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