公开(公告)号：EP2687854A1

公开(公告)日：2014-01-22

申请号：EP12177125.7

申请日：2012-07-19

Applicant: Chiron AS

Inventor： Karlsen, Morten Salihi ,  Liu, Huiling ,  Johansen, Jon Eigill

IPC: G01N33/94

CPC classification number: G01N33/94 ,  G01N30/72 ,  G01N33/946

Abstract: A test kit for the quantitative determination of narcotic drugs comprising
(A) series of sealed vessels, each vessel containing a deuterium free isotopologue of a narcotic drug in exactly defined concentrations and quantities,
- wherein the isotopologue differs from vessel to vessel and
- wherein the quantities of the isotopologue differ from vessel to vessel or are the same for all vessels; and/or

(B) series of sealed vessels, each vessel containing in exactly defined concentrations and quantities the same isotopologue in quantities which differ from vessel to vessel;
- wherein the free isotopologues are selected from narcotic drugs; prodrugs, salts, solvates, hydrates and polymorphs and

contain at least three stable isotopes selected from the group consisting of 13 C, 15 N and 18 O in the molecule with a degree of labeling of at least 95 mol-%;
the use of the test kit and a method for quantitatively determining narcotic drugs.

Abstract translation: 一种用于定量测定麻醉药物的试剂盒，包括（A）系列密封容器，每个容器含有精确定义的浓度和数量的麻醉药物的无氘游离同位素学，其中同位素学不同于血管与血管，其中 数量的同位素学因血管而异，或者对于所有血管都是相同的; 和/或（B）系列密封容器，每个容器的精确定义浓度和数量不同于容器与容器的量相同的同位素; - 其中游离同位素学选自麻醉药物; 前药，盐，溶剂化物，水合物和多晶型物，并且在分子中含有至少三种选自13 C，15 N和18 O的稳定同位素，其标记度至少为95mol％。 使用检测试剂盒和定量测定麻醉药物的方法。

公开(公告)号：EP4527829A1

公开(公告)日：2025-03-26

申请号：EP23198578.9

申请日：2023-09-20

Applicant: Chiron AS

Inventor： Liu, Huiling

IPC: C07C51/09 ,  C07C51/41 ,  C07C51/43 ,  C07C67/14 ,  C07C53/21 ,  C07C69/63 ,  C07C201/00

Abstract: The present invention is directed to poly- and perfluoroalkyl sulfonic acids and poly- and perfluoroalkyl acids and processes for the purification and isolation of isomers from mixtures as well as highly pure poly- and perfluoroalkyl sulfonic acids and poly- and perfluoroalkyl acids and the corresponding uses.

公开(公告)号：EP2551675A1

公开(公告)日：2013-01-30

申请号：EP11175719.1

申请日：2011-07-28

Applicant: Chiron AS

Inventor： Karlsen, Morten ,  Liu, Huiling ,  Johansen, Jon Eigill

IPC: G01N33/94 ,  G01N33/96

CPC classification number: G01N33/946 ,  A61K31/137 ,  C07C209/325 ,  G01N33/94 ,  G01N33/96 ,  G01N2560/00 ,  Y10T436/10 ,  Y10T436/173845

Abstract: Deuterium free, stable isotope labeled hallucinogens and/or stimulants containing a 2-phenylethylamine-based structural unit and containing at least three stable isotopes selected from the group consisting of 13 C, 15 N and 18 O as free bases and as their salts; method of their preparation and their use in the chemical analysis, in particular forensic chemical analysis, and in metabolic studies.

Abstract translation: 自由氘，稳定同位素标记选自13 C，选择致幻剂和/或含有一个基于2-苯基结构单元和含有至少三个稳定同位素兴奋剂15 N和18 O作为游离碱和盐及其; 其制备及其在化学分析中的应用，特别是法医化学分析，并在代谢研究方法。