公开(公告)号：US20240209397A1

公开(公告)日：2024-06-27

申请号：US18287604

申请日：2022-05-17

Applicant: Commonwealth Scientific and Industrial Research Organisation

Inventor： Ruhani Singh ,  Daniel Layton ,  Cara Doherty ,  Xavier Mulet ,  Benjamin Muir

IPC: C12N15/88 ,  A61K47/02 ,  A61K47/24 ,  A61K47/54 ,  A61K47/69 ,  A61K48/00

CPC classification number: C12N15/88 ,  A61K47/02 ,  A61K47/24 ,  A61K47/543 ,  A61K47/6911 ,  A61K48/0041

Abstract: The present application relates to metal-organic framework (MOF) encapsulation of lipid-nucleic acid formulations. The present application discloses methods for stabilizing lipid-nucleic acid formulations and provides MOF encapsulated lipid-nucleic acid formulations with improved stability.