公开(公告)号：JPH06128215A

公开(公告)日：1994-05-10

申请号：JP27842492

申请日：1992-10-16

Applicant: DAICEL CHEM

Inventor： FUTAGAWA TORU

IPC: B01J31/02 ,  C07B61/00 ,  C07C269/04 ,  C07C271/28

Abstract: PURPOSE:To produce an alkyl-N-arylcarbamate from an alkyl aryl carbonate as a raw material. CONSTITUTION:An alkyl-N-arylcarbamate is reacted with a nitrogen-containing heterocyclic compound such as imidazole or 2-hydroxypyridine in the presence of a primary or a secondary arylamine as a catalyst. This method is a new method for producing a carbamate by using an alkyl-N-arylcarbamate as a carbonic acid ester against the well-known production of carbamate using a carbonic ester with a dialkyl carbonate and 2 diaryl carbonate.

公开(公告)号：JPH06145133A

公开(公告)日：1994-05-24

申请号：JP29981892

申请日：1992-11-10

Applicant: DAICEL CHEM

Inventor： MURATA KIYOKAZU ,  FUTAGAWA TORU

IPC: B01D11/04 ,  C07C269/08 ,  C07C271/06

Abstract: PURPOSE:To recover a diurethane compound contained in waste water and prevent the clogging due to the deposition of the diurethane compound. CONSTITUTION:A diurethane compound contained in rejected waste water is recovered with a solvent in a step for removing a salt produced in neutralizing an alkaline catalyst used in reacting a diamine compound with dimethyl carbonate and producing the corresponding diurethane compound. Thereby, the diurethane compound which is a valuable in the waste water rejected in removing the neutralized salt produced in synthesizing the diurethane compound can be recovered at a low cost without carrying out the solid-liquid separating operation and pipes for flowing the waste water can be prevented from clogging.

公开(公告)号：JP2000256220A

公开(公告)日：2000-09-19

申请号：JP6135799

申请日：1999-03-09

Applicant: DAICEL CHEM

Inventor： FUTAGAWA TORU ,  WAKATSUKI AKIHIRO

IPC: C07D279/28 ,  B01J20/24 ,  B01J20/281 ,  C07B57/00 ,  C07C253/34 ,  C07C255/43 ,  C07D213/38 ,  G01N30/88 ,  G01N30/48

Abstract: PROBLEM TO BE SOLVED: To obtain a separating agent which does cause the tailing phenomenon of an analysis target compound on its separation and well separates the compound, by using a polysaccharide derivative derived from a polysaccharide containing one or more ions in specific concentrations, respectively. SOLUTION: This separating agent comprises a polysaccharide derivative [for example, amylose tris(3,5-dimethylphenylcarbamate)] derived from a polysaccharide (for example, cellulose or amylose) which contains one or more ions selected from chloride ion, nitrate ion, phosphate ion, sulfate ion, sodium ion, ammonium ion, potassium ion, calcium ion, and magnesium ion in concentrations of

公开(公告)号：JPH07126227A

公开(公告)日：1995-05-16

申请号：JP27169293

申请日：1993-10-29

Applicant: DAICEL CHEM

Inventor： FUTAGAWA TORU

IPC: C07B57/00 ,  C07B63/00 ,  C07C213/10 ,  C07C215/08

Abstract: PURPOSE:To efficiently obtain the compound by optically resolving the mixture of the optical active isomers of a beta-hydroxyarylethylamine compound by liquid chromatography using a separating agent containing a polysaccharide derivative as an active ingredient. CONSTITUTION:The mixture of the optically active isomers of a beta- hydroxyarylethylamine of the formula (X is 1-4C alkyl or alkoxy, nitro, halogen, amino, lower alkyl-substituted amino, cyano, OH, COOH; n is 0-15; * exhibits an asymmetric carbon) is optically resolved with liquid chromatography using a polysaccharide as an optically active solid phase to obtain the optically active beta-hydroxyarylethylamine compound. The separating agent is especially the ester compound, carbamate compound or ether compound of a homopolysaccharide such as cellulose, amylose or chitin, e.g. cellulose tribenzoate. The method simply, reproducibly and effectively give the subject compound useful as an intermediate for in an industrial scale by the simple chromatographic technique.

公开(公告)号：JPH06107620A

公开(公告)日：1994-04-19

申请号：JP26186992

申请日：1992-09-30

Applicant: DAICEL CHEM

Inventor： FUTAGAWA TORU ,  TERADA MASAHIKO

IPC: B01J27/02 ,  B01J27/10 ,  B01J27/16 ,  B01J31/02 ,  C07B61/00 ,  C07C269/06 ,  C07C271/44 ,  C07D307/86

Abstract: PURPOSE:To obtain a method for simply producing a carbamate at a low cost. CONSTITUTION:The objective method for producing an aryl N-substituted carbamate comprises reacting an N-substituted carbamic acid ester with an aryl alcohol in the presence of a Brphinsted acid catalyst. Thereby, the objective aryl N-substituted carbamate can be produced simply by using a small amount of the inexpensive Brphinsted acid catalyst.

公开(公告)号：JP2003326160A

公开(公告)日：2003-11-18

申请号：JP2003073009

申请日：2003-03-18

Applicant: Daicel Chem Ind Ltd ,  ダイセル化学工業株式会社

Inventor： ONISHI ATSUSHI ,  FUTAGAWA TORU

IPC: G01N30/46 ,  B01D15/08 ,  B01J20/24 ,  B01J20/281 ,  B01J20/283 ,  B01J20/30 ,  G01N30/56 ,  G01N30/84 ,  G01N30/86 ,  G01N30/88 ,  G01N30/48

Abstract: PROBLEM TO BE SOLVED: To provide a method of manufacturing a filler for liquid chromatography which enables good optical isomer separation of a target compound. SOLUTION: In the method of manufacturing a filler for liquid chromatography, a process where the required amount of a dope of a polysaccharide derivative is divided into a plurality of parts and a part of the dope of the polysaccharide derivative is applied to a porous carrier to be dried is repeated a plurality of times, and the required amount of the polysaccharide derivative is carried by the porous carrier. The quantity of the carried polysaccharide derivative in the filler is 20 mass% or higher. A TS (tetrakis(trimethylsilyl)silane) coefficient obtained by using a column for optical isomer separation for liquid chromatography prepared by packing the filler into a column pipe is in the range of 0.25 to 1.0. COPYRIGHT: (C)2004,JPO

Abstract translation: 待解决的问题：提供一种制造液相色谱填充剂的方法，其能够使目标化合物具有良好的旋光异构体分离。 解决方案：在制备液相色谱填充剂的方法中，将所需量的多糖衍生物的掺杂物分成多个部分，并将一部分多糖衍生物的掺杂物施加到 多次将要干燥的多孔载体重复多次，所需量的多糖衍生物由多孔载体承载。 载体中多糖衍生物在填料中的量为20质量％以上。 通过使用用于通过将填料填充到柱管中制备的用于液相色谱的旋光异构体分离柱获得的TS（四（三（三甲基甲硅烷基）硅烷））系数在0.25至1.0的范围内。 版权所有（C）2004，JPO

公开(公告)号：JP2001296288A

公开(公告)日：2001-10-26

申请号：JP2000116437

申请日：2000-04-18

Applicant: DAICEL CHEM

Inventor： ONISHI ATSUSHI ,  FUTAGAWA TORU

IPC: B01J20/291 ,  B01J20/281 ,  C07B57/00 ,  C07C29/76 ,  C07C33/40 ,  C07C45/79 ,  C07C49/83 ,  G01N30/88 ,  G01N30/48

Abstract: PROBLEM TO BE SOLVED: To provide a filler and a column for liquid chromatography, giving superior optical isomer separation relative to an object compound. SOLUTION: In this filler for optical isomer separation for liquid chromatography, made of a polysaccharide derivative carrying filler as a main component and a column in which the filler is filled, a TS coefficient defined by the following formula (I) is in the range of 0.25 to 1.0. TS coefficient=[Vc-[t(TS)-t(blank)]×FR]/[t(TS)-t(blank)]×ER (I) [In the formula, abbreviations mean Vc (cm3): a column volume, FR (ml/min.): a flow velocity, t(TS) (min.): an elution time of Tetrakis(trimethylsily)silane(=TS), and t(blank)(min.): elution time for TS in the state with the column not connected].

公开(公告)号：JPH10249191A

公开(公告)日：1998-09-22

申请号：JP6288897

申请日：1997-03-17

Applicant: DAICEL CHEM

Inventor： FUTAGAWA TORU

IPC: C07D279/04 ,  B01J20/24 ,  B01J20/283 ,  C07C209/88 ,  C07C211/52 ,  C07C251/88 ,  C08B37/00 ,  G01N30/88

Abstract: PROBLEM TO BE SOLVED: To prevent the tailing of a compd. to be analyzed and to attain satisfactory separation by using a separating agent made of a polysaccharide deriv. carried on modified silica gel having a specified carbon content as a carrier. SOLUTION: A polysaccharide deriv., preferably an ester or carbamate deriv., especially preferably amylose tris (3,5-dimethylphenylcarbamate) is carried on modified silica gel having >=1.8wt.%, preferably 1.8 to about 5.0wt.% carbon content as a carrier. The size of the modified silica gel depends on the size of a column used but the particle diameter of the silica gel is usually 1μm to about 10mm, preferably 1μm to about 300μm. The silica gel is preferably porous and the pref. average pore diameter is 10Å to 100μm, especially about 50-50,000Å.

公开(公告)号：JPH08268920A

公开(公告)日：1996-10-15

申请号：JP7755595

申请日：1995-04-03

Applicant: DAICEL CHEM

Inventor： FUTAGAWA TORU

IPC: C07D279/28 ,  C07B57/00 ,  C07C253/34 ,  C07C255/43 ,  C07D213/38

Abstract: PURPOSE: To obtain a separating agent having no tailing of an objective compound, excellent in separating properties, useful as a separating agent for optical resolution of racemic modification by cleaning a separating agent comprising a polysaccharide derivative derived from a polysaccharide containing a specific amount of ions with a solvent containing an amine. CONSTITUTION: A separating agent comprising a polysaccharide derivative derived from a polysaccharide having

公开(公告)号：JPH07330690A

公开(公告)日：1995-12-19

申请号：JP12867294

申请日：1994-06-10

Applicant: DAICEL CHEM

Inventor： FUTAGAWA TORU

IPC: C07C209/74 ,  C07C211/52 ,  C07C239/20 ,  C07C273/18 ,  C07C275/30

Abstract: PURPOSE:To efficiently and easily obtain the derivative useful as an intermediate for medicines, agricultural chemicals, etc., by using a specific dialkylphenylamine derivative as a starting raw material. CONSTITUTION:(A) A 3,5-dialkylphenylamine derivative of formula I (R , R are H, 1-8C saturated hydrocarbon, 5-12C alicyclic hydrocarbon, 1-4C alkoxy, 1-4C alkyl-substituted amino, 1-4C alkyl-substituted amide; R , R are 1-4C alkyl) is reacted with (B) a halogenated succinimide to obtain the derivative of formula II [ (x) is halogen; (n) is 1-3 which are the number of (x)]. The component B includes N-chlorosuccinimide, and the reaction is performed in a solvent such as carbon tetrachloride at 0-100 deg.C under the atmospheric pressure to 10kg/cm G, etc.