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    NEW NITRILASE AND PRODUCTION AND 2-HYDROXY-4- METHYLTHIOBUTYLIC ACID
    4.
    发明专利
    NEW NITRILASE AND PRODUCTION AND 2-HYDROXY-4- METHYLTHIOBUTYLIC ACID 失效

    公开(公告)号：JP2001054380A

    公开(公告)日：2001-02-27

    申请号：JP22910999

    申请日：1999-08-13

    Applicant: DAICEL CHEM

    Inventor： NAGASAWA TORU ,  MATSUYAMA AKIKAZU

    IPC: C12N9/78 ,  C12N1/20 ,  C12P13/00

    Abstract: PROBLEM TO BE SOLVED: To obtain a new nitrilase having ammonia resistance, and useful for production of 2-hydroxy-4-methylthiobutylic acid(HMBA) useful as an additive to a feed. SOLUTION: This new nitrilase is derived from Rhodococcus rhodochrous, and has the following physicochemical properties: action: catalyzing the reaction for hydrolyzing a nitrile group to form a carboxylic acid group and ammonia; molecular weight: 40 kDa (by electrophoresis), or 400 kDa (by gel filtration); substrate specificity: acting on aliphatic, aromatic and heterocyclic nitriles; temperature stability: when treated at pH 6.5 for 15 min, being stable up to 40 deg.C, containing about 40% discernible deactivation at 50 deg.C, and being completely deactivated at 60 deg.C or higher; optimum temperature: about 50 deg.C; stabilizer: 1 mM dithiothreitol or 1 mM mercaptoethanol; inhibitor: deactivated with Hg++, Cu++ or the like; ammonia resistance: not inhibited by 1.5 M ammonium sulfate. Further, the HMBA can be obtained by allowing Rhodococcus rhodochrous B24-1 (FERM P-17515) to act on 2-hydroxy-4-methylthiobutylonitrile.

    Method for producing adamantane polyol
    5.
    发明专利
    Method for producing adamantane polyol 审中-公开
    生产聚氨酯多元醇的方法

    公开(公告)号：JP2008173055A

    公开(公告)日：2008-07-31

    申请号：JP2007009667

    申请日：2007-01-19

    Applicant: Daicel Chem Ind Ltd ,  Gifu Univ ,  ダイセル化学工業株式会社 ,  国立大学法人岐阜大学

    Inventor： NAGASAWA TORU ,  YOSHIDA TOYOKAZU ,  MITSUKURA KOICHI ,  MATSUYAMA AKIKAZU

    IPC: C12N1/20 ,  C12P7/18

    Abstract: PROBLEM TO BE SOLVED: To provide a method for producing an adamantane polyol by a regioselective hydroxylation reaction of adamantanol and/or adamantane diol using a microorganism.
    SOLUTION: Search is intensively carried out on the microorganism for regioselectively hydroxylating the adamantanol and/or the adamantane diol. As a result, a high regioselective hydroxylating activity for the adamantanol and/or the adamantane diol is found out in the genus Streptomyces and the genus Kitasatospora in which the activity is conventionally unknown. Thus, the method for producing the adamantane polyol using the microorganism is completed. That is, the method for producing the adamantane polyol comprising a step of reacting the adamantanol and/or the adamantane diol with the microorganism belonging to the genus Streptomyces or a treated substance thereof or the microorganism belonging to the genus Kitasatospora or a treated substance thereof is provided.
    COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 待解决的问题：提供通过使用微生物的金刚烷醇和/或金刚烷二醇的区域选择性羟基化反应来生产金刚烷多元醇的方法。 解决方案：密集地对微生物进行搜索以使金刚烷醇和/或金刚烷二醇的区域选择性羟基化。 结果，在链霉菌属和北起孢菌属中发现金刚烷醇和/或金刚烷二醇的高区域选择性羟基化活性，其中活性通常是未知的。 因此，完成了使用微生物生产金刚烷多元醇的方法。 也就是说，金刚烷多元醇的制造方法，其特征在于，使金刚烷醇和/或金刚烷二醇与属于链霉菌属的微生物或其处理物质或属于北起孢菌属的微生物或其处理物质反应的工序是 提供。 版权所有（C）2008，JPO＆INPIT

    NEW MICROORGANISM AND PRODUCTION OF AMIDE COMPOUND
    7.
    发明专利
    NEW MICROORGANISM AND PRODUCTION OF AMIDE COMPOUND 失效

    公开(公告)号：JP2000175681A

    公开(公告)日：2000-06-27

    申请号：JP35622998

    申请日：1998-12-15

    Applicant: DAICEL CHEM

    Inventor： MATSUYAMA AKIKAZU ,  KAWABE MASATO ,  NAGASAWA TORU

    IPC: C12N15/09 ,  C12N1/20 ,  C12P13/02 ,  C12R1/01

    Abstract: PROBLEM TO BE SOLVED: To obtain a new microorganism as a kind of microorganisms containing 16S rRNA gene having specific base sequences, having the ability to convert a nitrile to the corresponding amide in high production efficiency, and useful in e.g. producing an amide compound for producing feed additives, or the like. SOLUTION: The new kind of microorganism is e.g. Rhodococcus sp.Cr4 strain (FERM BP-6596), containing 16S rRNA gene having respective base sequences of formula I and formula II and having the ability to convert a nitrile to the corresponding amide, thus being useful in producing the corresponding amide compound from a nitrile such as a cyanohydrin of formula III (R1 is a hydrocarbon group or heterocyclic group optionally having substituent(s)). The Rhodococcus sp.Cr4 strain as the new kind of microorganisms has been afforded by isolation using an accumulation method by culture in a selective medium from the soil collected from a certain field soil in Okayama City, Okayama Prefecture, Japan.

    METHOD FOR PRODUCING CARBOXYLIC ACID
    8.
    发明专利
    METHOD FOR PRODUCING CARBOXYLIC ACID 审中-公开

    公开(公告)号：JP2006223246A

    公开(公告)日：2006-08-31

    申请号：JP2005043757

    申请日：2005-02-21

    Applicant: UNIV GIFU ,  DAICEL CHEM

    Inventor： NAGASAWA TORU ,  YOSHIDA TOYOKAZU ,  MATSUYAMA AKIKAZU

    IPC: C12P41/00 ,  C12R1/06

    Abstract: PROBLEM TO BE SOLVED: To provide a nitrilase-producing microorganism having high resistance to organic solvents, and to provide a method for efficiently producing a carboxylic acid from a nitrile, by utilizing nitrilase activity of the microorganism. SOLUTION: In this method for producing the carboxylic acid, the microorganism, which belongs to the genus Arthrobacter, in which 10% or more of the nitrilase activity is left in case of being treated at 20°C for 60 min in the presence of a 40%-organic solvent, and which concretely comprises a substance having the nitrilase activity comprising an Arthrobacter SP F-73 strain and/or its treated product, is brought into contact with the nitrile in a reaction liquid which is formed by adding an organic solvent to an aqueous reaction liquid, and then the carboxylic acid which is formed by hydrolyzing the nitrile is recovered. COPYRIGHT: (C)2006,JPO&NCIPI

    Method for producing adamantanol
    9.
    发明专利
    Method for producing adamantanol 有权
    生产ADAMANTANOL的方法

    公开(公告)号：JP2005229859A

    公开(公告)日：2005-09-02

    申请号：JP2004041072

    申请日：2004-02-18

    Applicant: Daicel Chem Ind Ltd ,  ダイセル化学工業株式会社

    Inventor： NAGASAWA TORU ,  MITSUKURA KOICHI

    IPC: C12P7/04 ,  C12N1/14 ,  C12N1/20 ,  C12R1/465

    Abstract: PROBLEM TO BE SOLVED: To provide a method for producing adamantanol by site-selective hydroxylation reaction of adamantane using a microorganism.
    SOLUTION: The method for producing adamantanol from adamantane comprises a process for treating adamantane with a cell body of a microorganism belonging to the genus Streptomyces or Dothiora or its treated material.
    COPYRIGHT: (C)2005,JPO&NCIPI

    Abstract translation: 待解决的问题：提供通过使用微生物的金刚烷的位置选择性羟基化反应来生产金刚烷的方法。 解决方案：金刚烷生产金刚烷的方法包括用属于链霉菌属或Dothiora属的微生物细胞体或其处理物质处理金刚烷的方法。 版权所有（C）2005，JPO＆NCIPI

    Method for producing sorbic alcohol
    10.
    发明专利
    Method for producing sorbic alcohol 审中-公开
    生产醇类的方法

    公开(公告)号：JP2005021099A

    公开(公告)日：2005-01-27

    申请号：JP2003191408

    申请日：2003-07-03

    Applicant: Daicel Chem Ind Ltd ,  ダイセル化学工業株式会社

    Inventor： NAGASAWA TORU ,  YOSHIDA TOYOKAZU ,  MATSUYAMA AKIKAZU

    IPC: C12P7/04 ,  C12N1/14 ,  C12R1/645

    Abstract: PROBLEM TO BE SOLVED: To provide a method for readily and inexpensively producing sorbic alcohol in an industrial scale.
    SOLUTION: It is found that microorganisms belonging to the genuses of Verticillium, Beauver, Mucor, Rhizopus and Hypocrea have excellent abilities for producing the sorbic alcohol. The sorbic alcohol is readily and efficiently produced by using the biomass of the microorganisms or a treated product thereof.
    COPYRIGHT: (C)2005,JPO&NCIPI

    Abstract translation: 要解决的问题：提供一种以工业规模容易且廉价地生产山梨醇的方法。 解决方案：发现属于轮枝孢菌属，白僵菌属，毛霉属，根霉属和低分子属的微生物具有优异的山梨醇生产能力。 通过使用微生物的生物质或其处理产物容易且有效地产生山梨醇。 版权所有（C）2005，JPO＆NCIPI

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