公开(公告)号：DE59409542D1

公开(公告)日：2000-11-09

申请号：DE59409542

申请日：1994-05-11

Applicant: DEGUSSA

Inventor： WAGNER PROF DR ,  VOELKEL DIRK ,  BOMMARIUS DR ,  DRAUZ PROF DR

IPC: C12N1/20 ,  C12N1/21 ,  C12N9/80 ,  C12N9/86 ,  C12N9/90 ,  C12N15/09 ,  C12N15/55 ,  C12N15/61 ,  C12P13/04 ,  C12P41/00 ,  C12R1/06

Abstract: N-5-Monosubstituted hydantoins can be converted by fermentation or enzymatically into the enantiomerically pure L- alpha -amino acid. The object comprises microorganisms which are simple to cultivate and make high L- alpha -amino acid yields possible from various substrates. The microorganisms DSM 7329 and 7330 are suitable for the production of L- alpha -amino acids from corresponding hydantoins or carbamoyl- alpha -amino acids. The reaction is preferably carried out with dormant microorganisms. Production of various L- alpha -amino acids.

公开(公告)号：DE59810880D1

公开(公告)日：2004-04-08

申请号：DE59810880

申请日：1998-07-18

Applicant: DEGUSSA

Inventor： KOTTENHAHN DR ,  MOELLER ROLAND ,  KRAFT MICHAEL ,  DRAUZ PROF DR ,  STINGL DR

IPC: C07K1/30 ,  A61K38/00 ,  C07K5/02 ,  C07K5/068

Abstract: Isolation of 1-ÄN -((S)-ethoxycarbonyl)-3-phenylpropyl)-N -trifluoroacetylÜ-L- lysyl-L-proline (I) (i.e. lisinoprilÄTFAÜ ethyl ester) from an aqueous solution obtained in the production of (I), comprises extraction followed by crystallisation. The novelty is that the solvent (or solvent mixture) used for extraction of (I) is also a major component of the solvent (mixture) used for crystallisation of (I). Also claimed is (I) which exhibits reflections at 6.7241, 9.4851, 11.9034, 16.3074 and 17.8722 (2&thetas; ).

公开(公告)号：DE59905279D1

公开(公告)日：2003-06-05

申请号：DE59905279

申请日：1999-03-19

Applicant: DEGUSSA

Inventor： GUENTHER DR ,  KUNZ DR ,  DRAUZ PROF DR ,  MUELLER DR

IPC: C07K1/20 ,  C07K1/12 ,  C07K1/36 ,  C07K7/23 ,  G01N30/46 ,  G01N30/88