公开(公告)号：AT361905T

公开(公告)日：2007-06-15

申请号：AT04803202

申请日：2004-11-20

Applicant: DEGUSSA

Inventor： HOFFMANN ROLF ,  KRAFT MICHAEL

IPC: C07B57/00 ,  C07C227/34 ,  C12P13/04

Abstract: The present invention is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallization with enantiomerically pure N-unprotected &bgr;-amino acid derivatives.

公开(公告)号：DE4425071A1

公开(公告)日：1996-02-08

申请号：DE4425071

申请日：1994-07-15

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ PROF DR ,  KOTTENHAHN MATTHIAS DR ,  KRAFT MICHAEL ,  SCHWARM MICHAEL DR

IPC: C07B53/00 ,  C07D207/12 ,  C07D207/40

Abstract: Prodn. of optically active 3-hydroxypyrrolidines of formula (I) having high enantiomeric purity comprises reducing an enantiomerically pure 3-hydroxy-2,5-pyrrolidinedione of formula (II) with an activated alkali borohydride. R = H or OH; R = benzyl opt. ring-substd. by 1 or more alkyl, alkoxy and/or halo; * = asymmetric centre. (I) are intermediates for carbapenem antibiotics, see Chemotherapy 1991, 39 (Suppl. 3), 88 et seq., Tetrahedron Lett. 1984, 25 (26), 2793, JP04036282, JP 03275685 and Korean J. Med. Chem. 1993,3 (1), 72. (I) are also intermediates for optically active phosphanes useful as metal catalyst ligands in asymmetric hydrogenations, see Chem. Ber. 1986, 119, 3326, DE3446303, DE3403194 and Bull. Chem. Soc. Jpn. 1984, 57 (3), 823. In contrast to known reductive processes for the prodn. of (I) described in Chem. Ber. 1986, 119, 3327, JP 03200762, JP 01254657 and JP 01207266, the method is simple to perform and uses materials which are inexpensive and do not give rise to health or environmental problems. Yields are typically 52.1% to quantitative and enantiomeric purity is high (not quantified).

公开(公告)号：DE3482108D1

公开(公告)日：1990-06-07

申请号：DE3482108

申请日：1984-11-07

Applicant: DEGUSSA

Inventor： ANDRADE JUAN DR DIPL CHEM ,  ARNTZ DIETRICH DR DIPL CHEM ,  KRAFT MICHAEL ,  PRESCHER GUENTER DR DIPL CHEM

IPC: C07C41/50 ,  B01J21/00 ,  B01J29/00 ,  B01J31/00 ,  C07B61/00 ,  C07C41/00 ,  C07C41/56 ,  C07C41/58 ,  C07C43/303 ,  C07C67/00

Abstract: A method of preparation for acetals utilizing saturated or unsaturated aldehydes, in particular, the preparation of dimethylacetals of acetaldehyde, acrolein and methacrolein. The production of the acetal takes place in a liquid phase in the presence of a solid acid catalyst, such as a strongly acidic ion exchange resin or zeolite. The conversion mixture is extracted by means of water and by means of water insoluble organic solvents. There is obtained not only the desired acetals, but in addition also the unconverted initial quantities of the starting materials by a simple method and with very good yields.

公开(公告)号：CA1236487A

公开(公告)日：1988-05-10

申请号：CA473216

申请日：1985-01-30

Applicant: DEGUSSA

Inventor： ANDRADE JUAN ,  ARNTZ DIETRICH ,  KRAFT MICHAEL ,  PRESCHER GUENTER

IPC: C07C41/50 ,  B01J21/00 ,  B01J29/00 ,  B01J31/00 ,  C07B61/00 ,  C07C41/00 ,  C07C41/56 ,  C07C41/58 ,  C07C43/303 ,  C07C67/00

Abstract: The present process is intended for producing the acetals of saturated or unsaturated aldehydes particularly for producing the dimethyl acetals of acrolein and methacrolein. The acetals are formed in the liquid phase in the presence of solid acid catalysts such as strongly acid ion exchange resins or zeollites. The reaction mixtures are extracted by means of water and by means of organic solvents which are,not miscible with water. The acetals formed are recovered in a simple manner and in very good yields and so are the non-reaeted components of the starting substances .

公开(公告)号：DE2839565A1

公开(公告)日：1980-03-27

申请号：DE2839565

申请日：1978-09-12

Applicant: DEGUSSA

Inventor： GIESSELMANN GUENTHER DR ,  GUENTHER KURT DR ,  KRAFT MICHAEL

IPC: C10C1/08 ,  A61K35/04

公开(公告)号：DE602004006438T2

公开(公告)日：2008-01-10

申请号：DE602004006438

申请日：2004-11-20

Applicant: EVONIK DEGUSSA GMBH

Inventor： HOFFMANN ROLF ,  KRAFT MICHAEL

IPC: C07B57/00 ,  C07C227/34 ,  C12P13/04

Abstract: The present invention is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallization with enantiomerically pure N-unprotected &bgr;-amino acid derivatives.

公开(公告)号：CA2547733A1

公开(公告)日：2005-06-30

申请号：CA2547733

申请日：2004-11-20

Applicant: DEGUSSA

Inventor： HOFFMANN ROLF ,  KRAFT MICHAEL

IPC: C07B57/00 ,  C07C227/34 ,  C12P13/04

Abstract: The present invention relates to a process for the resolution of derivatives of alpha-amino acids. In particular the process is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallisation with enantiomerically pure N-unprotected beta-amino aci d derivatives.

公开(公告)号：DE19832405A1

公开(公告)日：1999-02-04

申请号：DE19832405

申请日：1998-07-18

Applicant: DEGUSSA

Inventor： KOTTENHAHN MATTHIAS DR ,  MOELLER ROLAND ,  KRAFT MICHAEL ,  DRAUZ KARLHEINZ PROF DR ,  STINGL KLAUS DR

IPC: C07K1/30 ,  A61K38/00 ,  C07K5/02 ,  C07K5/068 ,  C07K5/078

Abstract: Isolation of 1-N -((S)-ethoxycarbonyl)-3-phenylpropyl)-N -trifluoroacetyl-L- lysyl-L-proline (I) (i.e. lisinoprilTFA ethyl ester) from an aqueous solution obtained in the production of (I), comprises extraction followed by crystallisation. The novelty is that the solvent (or solvent mixture) used for extraction of (I) is also a major component of the solvent (mixture) used for crystallisation of (I). Also claimed is (I) which exhibits reflections at 6.7241, 9.4851, 11.9034, 16.3074 and 17.8722 (2 eta ).

公开(公告)号：AT53830T

公开(公告)日：1990-06-15

申请号：AT84113390

申请日：1984-11-07

Applicant: DEGUSSA

Inventor： ANDRADE JUAN DR DIPL-CHEM ,  ARNTZ DIETRICH DR DIPL-CHEM ,  KRAFT MICHAEL ,  PRESCHER GUENTER DR DIPL-CHEM

IPC: C07C41/50 ,  B01J21/00 ,  B01J29/00 ,  B01J31/00 ,  C07B61/00 ,  C07C41/00 ,  C07C41/56 ,  C07C41/58 ,  C07C43/303 ,  C07C67/00

公开(公告)号：DE59810880D1

公开(公告)日：2004-04-08

申请号：DE59810880

申请日：1998-07-18

Applicant: DEGUSSA

Inventor： KOTTENHAHN DR ,  MOELLER ROLAND ,  KRAFT MICHAEL ,  DRAUZ PROF DR ,  STINGL DR

IPC: C07K1/30 ,  A61K38/00 ,  C07K5/02 ,  C07K5/068

Abstract: Isolation of 1-ÄN -((S)-ethoxycarbonyl)-3-phenylpropyl)-N -trifluoroacetylÜ-L- lysyl-L-proline (I) (i.e. lisinoprilÄTFAÜ ethyl ester) from an aqueous solution obtained in the production of (I), comprises extraction followed by crystallisation. The novelty is that the solvent (or solvent mixture) used for extraction of (I) is also a major component of the solvent (mixture) used for crystallisation of (I). Also claimed is (I) which exhibits reflections at 6.7241, 9.4851, 11.9034, 16.3074 and 17.8722 (2&thetas; ).