公开(公告)号：DE19506728A1

公开(公告)日：1996-08-29

申请号：DE19506728

申请日：1995-02-27

Applicant: DEGUSSA

Inventor： EFFENBERGER FRANZ PROF DR ,  EICHHORN JOACHIM ,  ROOS JUERGEN

IPC: C07C45/30 ,  C07C255/16 ,  C07D307/33 ,  C12N11/12 ,  C12N11/14 ,  C12P13/00 ,  C07D307/32

Abstract: Prodn. of (R)-pantolactone (III) comprises: (a) reacting a beta -substd. pivalaldehyde of formula: X-CH2-C(CH3)2-CHO (I) with hydrogen cyanide in an aq. medium or an organic solvent contg. at least a trace of water, in the presence of a catalytic amt. of (R)-oxy-nitrilase (EC 4.1.2.10) to give the (R)-cyanohydrin isomer of formula: X-CH2-C(CH3)2-CH(CN)OH (II), and (b) hydrolysing in an acid medium, with cyclisation. X = halo, OR or OCOR; R = 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, aryl or aralkyl. The following cpds. (II) are new. (R)(-)-2-hydroxy-3,3-dimethyl -4-(bromo, chloro, methoxy, ethoxy or acetyl) butanonitrile.