公开(公告)号：DE3200994A1

公开(公告)日：1983-09-29

申请号：DE3200994

申请日：1982-01-15

Applicant: DEGUSSA

Inventor： EFFENBERGER FRANZ PROF DR ,  BEISSWENGER THOMAS DIPL CHEM D

IPC: C07C67/00 ,  C07C313/00 ,  C07C323/57 ,  C07D239/38 ,  C07C149/20 ,  C07C149/40

公开(公告)号：CH653994A5

公开(公告)日：1986-01-31

申请号：CH17783

申请日：1983-01-13

Applicant: DEGUSSA

Inventor： EFFENBERGER FRANZ PROF DR ,  BEISSWENGER THOMAS DR

IPC: C07C67/00 ,  C07C313/00 ,  C07C323/57 ,  C07D239/38 ,  C07C149/32

公开(公告)号：DE3140227C1

公开(公告)日：1982-12-16

申请号：DE3140227

申请日：1981-10-09

Applicant: DEGUSSA

Inventor： EFFENBERGER FRANZ PROF DR ,  BEISSWENGER THOMAS DIPL-CHEM

IPC: C07B61/00 ,  B01J23/00 ,  B01J23/36 ,  B01J27/00 ,  B01J27/04 ,  C07C67/00 ,  C07C231/00 ,  C07C231/10 ,  C07C231/18 ,  C07C233/46 ,  C07C233/47 ,  C07C313/00 ,  C07C319/20 ,  C07C323/59 ,  C07C103/46 ,  C07C103/48 ,  C07C149/41

Abstract: The subject matter of the invention is a process for the production of N-acetyl-2,3-dehydroaminocarboxylic acid esters by reaction of the corresponding 2-azido-carboxylic acid esters with a mixture of one part by volume of acetic anhydride and 1.5 to 5 parts by volume of acetic acid in the presence of rhenium VII sulfide and/or oxide and at a temperature between 50 DEG and 150 DEG C., in a given case, in the simultaneous presence of dry hydrogen chloride.

公开(公告)号：DE3778864D1

公开(公告)日：1992-06-11

申请号：DE3778864

申请日：1987-10-28

Applicant: DEGUSSA

Inventor： EFFENBERGER FRANZ PROF DR ,  ZIEGLER THOMAS DR ,  FOERSTER SIEGFRIED

IPC: C12N9/88 ,  C12P13/00 ,  C12P17/00 ,  C12P41/00

Abstract: A prepn. (I) comprises reacting aldehydes with hydrocyanic acid in the presence of D-oxynitrilase and an organic solvent which is immiscible with water but is satd. with water or an aq. buffer soln. Pref. the organic solvent is an aliphatic or aromatic hydrocarbon, a chlorinated aliphatic hydrocarbon, an ether, an alkyl ester of a carboxylic acid or an aliphatic or cycloaliphatic alcohol. The organic solvent is pref. satd. with an aq. buffer of pH 3-8.

公开(公告)号：AT75779T

公开(公告)日：1992-05-15

申请号：AT87115795

申请日：1987-10-28

Applicant: DEGUSSA

Inventor： EFFENBERGER FRANZ PROF DR ,  ZIEGLER THOMAS DR ,  FOERSTER SIEGFRIED

IPC: C12N9/88 ,  C12P13/00 ,  C12P17/00 ,  C12P41/00

公开(公告)号：DE3328986A1

公开(公告)日：1985-02-21

申请号：DE3328986

申请日：1983-08-11

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ DIPL CHEM DR ,  BURKARD ULRIKE DIPL CHEM ,  EFFENBERGER FRANZ PROF DR

IPC: C07D295/14 ,  C07C67/00 ,  C07C227/00 ,  C07C227/08 ,  C07C227/32 ,  C07C229/10 ,  C07C229/16 ,  C07C229/36 ,  C07D207/16 ,  C07D211/14 ,  C07D211/34 ,  C07D295/10 ,  C07D295/15 ,  C07C99/00 ,  C07C101/18 ,  C07C101/20

公开(公告)号：DE3261465D1

公开(公告)日：1985-01-17

申请号：DE3261465

申请日：1982-08-05

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ DR ,  EFFENBERGER FRANZ PROF DR ,  KLEEMANN AXEL DR ,  MARTENS JURGEN DR ,  SCHERBERICH PAUL DR

IPC: C07D207/16 ,  C07D207/22

Abstract: L-proline is produced from the methyl or ethyl ester of L-pyroglutamic acid by reacting this with at least twice the molar amount of phosgene to form the corresponding 1-chlorocarbonyl-5,5-dichloroproline ester, producing the corresponding 2-chloro-1-chlorocarbonyl-pyrrolin-(2)-carboxylic acid ester-(5) therefrom by splitting off hydrogen chloride, catalytically hydrogenating the pyrrolin-(2) compound to the corresponding N-chlorocarbonyl-proline ester and hydrolyzing the latter with acid to form L-proline.

公开(公告)号：DE3135840C1

公开(公告)日：1983-06-09

申请号：DE3135840

申请日：1981-09-10

Applicant: DEGUSSA

Inventor： EFFENBERGER FRANZ PROF DR ,  ZOLLER GERHARD DIPL-CHEM DR

IPC: C07C227/04 ,  C07C67/00 ,  C07C229/22 ,  C07C241/00 ,  C07C247/12 ,  C07C117/08

Abstract: The subject matter of the invention is the new 2-azido-3-benzyloxy-propionic acid benzyl ester which is a valuable intermediate product for the production of D,L-serine or derivatives of D,L-serine. The new compound is produced by reacting 2-chloroacrylonitrile with twice the molar amount of benzyl alcohol to form 3-benzyloxy-2-chloropropionic acid imino benzyl ester, saponifying this with acid to form 3-benzyloxy-2-chloropropionic acid benzyl ester, and finally exchanging the chlorine atom by means of an alkali metal azide in the presence of a phase transfer catalyst for an azido group.

公开(公告)号：DE2854627B1

公开(公告)日：1979-10-04

申请号：DE2854627

申请日：1978-12-18

Applicant: DEGUSSA

Inventor： EFFENBERGER FRANZ PROF DR ,  DRAUZ KARLHEINZ DIPL-CHEM DR

IPC: C07C229/02 ,  C07C20060101 ,  C07C67/00 ,  C07C227/00 ,  C07C227/06 ,  C07C227/18 ,  C07C227/20 ,  C07C229/08 ,  C07C229/26 ,  C07C101/04 ,  C07C101/24 ,  C07C99/00

Abstract: Aminoacid hydrochlorides or diaminoacid dihydrochlorides are produced by first reacting a halocarboxylic acid ester with an alkali metal cyanate in the presence of an alcohol to form the corresponding mono- or diurethane and then saponifying this to the corresponding mono- or dihydrochloride. The new process is relatively versatile in its use and above all opens up an elegant synthesis route for lysine.

公开(公告)号：DE19506728A1

公开(公告)日：1996-08-29

申请号：DE19506728

申请日：1995-02-27

Applicant: DEGUSSA

Inventor： EFFENBERGER FRANZ PROF DR ,  EICHHORN JOACHIM ,  ROOS JUERGEN

IPC: C07C45/30 ,  C07C255/16 ,  C07D307/33 ,  C12N11/12 ,  C12N11/14 ,  C12P13/00 ,  C07D307/32

Abstract: Prodn. of (R)-pantolactone (III) comprises: (a) reacting a beta -substd. pivalaldehyde of formula: X-CH2-C(CH3)2-CHO (I) with hydrogen cyanide in an aq. medium or an organic solvent contg. at least a trace of water, in the presence of a catalytic amt. of (R)-oxy-nitrilase (EC 4.1.2.10) to give the (R)-cyanohydrin isomer of formula: X-CH2-C(CH3)2-CH(CN)OH (II), and (b) hydrolysing in an acid medium, with cyclisation. X = halo, OR or OCOR; R = 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, aryl or aralkyl. The following cpds. (II) are new. (R)(-)-2-hydroxy-3,3-dimethyl -4-(bromo, chloro, methoxy, ethoxy or acetyl) butanonitrile.