公开(公告)号：JPH11322721A

公开(公告)日：1999-11-24

申请号：JP8193999

申请日：1999-03-25

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ ,  HOFFMANN ROLF DR ,  PELGRIMS IVAN

IPC: C07D233/32 ,  C07D233/70 ,  C07D235/02

Abstract: PROBLEM TO BE SOLVED: To advantageously obtain a cyclic 4-oxamidine useful in synthesis of extremely pure and biologically active substances, etc., in good yield or extremely excellent yield by oxidizing or dehydrogenating a specific cyclic compound or its salt. SOLUTION: In this method for producing a compound of formula I [R and R are each H, a 1-8C alkyl, 2-8C alkenyl or the like; R to R are each same as R ; (n) is 1-3], a cyclic compound of formula II or its salt is oxidized or dehydrogenated. Furthermore, the compound of formula II is preferably produced by reacting α-aminonitrile with an aldehyde and the oxidation is carried out by using a halogen or an agent from a group of a halogen derivative, especially by using Cl2 as an oxidizing agent and dehydrogenation is preferably carried out in the presence of Ru or an agent from a group of Ru, etc., especially palladium, in an organic solvent or a solvent mixture, especially in ketone within the temp. range of 50-250 deg.C.