公开(公告)号：DE3438289A1

公开(公告)日：1986-04-24

申请号：DE3438289

申请日：1984-10-19

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL DIPL CHEM DR ,  LUESSLING THEODOR DIPL CHEM DR ,  SCHAEFER FRIEDRICH DIPL CHEM D

IPC: C07D243/08 ,  A61K31/55

Abstract: Purification of dilazep base by an at least two-stage extraction with an organic acid having a pK between 3.0 and 4.90 or with a strong inorganic acid.

公开(公告)号：DE3403778A1

公开(公告)日：1985-08-08

申请号：DE3403778

申请日：1984-02-03

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL DIPL CHEM DR ,  LEHMANN BERND DIPL CHEM DR ,  DELLER KLAUS DIPL ING DR

IPC: A61K31/55 ,  B01J27/00 ,  C07B61/00 ,  C07C67/00 ,  C07C253/00 ,  C07C255/24 ,  C07D243/08 ,  C07D243/00

Abstract: There is disclosed a process for the production of 1,4-bis-[3-(3,4,5-trimethoxybenzyloxy)-propyl]-diazepane which consists of first reacting 3-aminopropanol with acrylonitrile and subsequently reacting in aqueous solution with formaldehyde and hydrocyanic acid or with formaldehyde and an alkali cyanide in the presence of alkali hydrogen sulfite to form cyanomethyl-(2-cyano-ethyl)-(3-hydroxy-propyl)-amine; hydrogenating the thus obtained reaction product in the presence of a hydrogenating catalyst and ammonia to 1 (3-hydroxy-propyl)-1,4-diazepane and reacting the latter compound for example with 3-halogen propanol or with allyl alcohol and introducing two 3,4,5-trimethoxy-benzoyl groups into the thus obtained reaction product by esterification.

公开(公告)号：DE3308726A1

公开(公告)日：1984-09-13

申请号：DE3308726

申请日：1983-03-11

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ DIPL CHEM DR ,  KLEEMANN AXEL DIPL CHEM DR

IPC: B01J27/00 ,  B01J27/02 ,  C07B61/00 ,  C07C27/00 ,  C07C37/60 ,  C07C39/08 ,  C07C67/00 ,  C07C41/26

公开(公告)号：DE3225307A1

公开(公告)日：1984-01-12

申请号：DE3225307

申请日：1982-07-07

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ DIPL CHEM DR ,  KLEEMANN AXEL DIPL CHEM DR ,  WIRTHWEIN ROLF DIPL CHEM DR

IPC: C01B15/017

公开(公告)号：DE3043159A1

公开(公告)日：1982-06-09

申请号：DE3043159

申请日：1980-11-15

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ DIPL CHEM DR ,  KLEEMANN AXEL DIPL CHEM DR ,  SAMSON MARC DR

IPC: C07D207/16 ,  C07D317/30 ,  C07D319/06 ,  C07D405/06

Abstract: The invention is directed to cyclic acetals of glutamic acid- gamma -semialdehyde of the formula (I) in which A is an unsubstituted alkylene group having 2 to 3 carbon atoms or such an alkylene group substituted by 1 to 2 methyl groups and to a method of producing a compound of formula (I) by reaction of a compound of the general formula (II) in which A is as defined above with hydrogen cyanide or a cyanide ion supplying compound, ammonia or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound and basic hydrolysis of the reaction mixture obtained and to using the compound of formula (I) to produce D,L-proline.

公开(公告)号：DE3006492A1

公开(公告)日：1981-08-27

申请号：DE3006492

申请日：1980-02-21

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL DIPL CHEM DR ,  SCHALKE PETER DIPL CHEM DR

IPC: C07C255/04 ,  C07C67/00 ,  C07C253/00 ,  C07C253/04 ,  C07C253/34 ,  C07C121/28 ,  C07C120/00

Abstract: Malononitrile is obtained for the first time from its reaction gas mixture obtained by reacting acetonitrile and cyanogen chloride by partial condensation in decreasing temperature steps, namely while avoiding contact with the simultaneously formed hydrogen chloride.

公开(公告)号：DE3209472A1

公开(公告)日：1983-09-29

申请号：DE3209472

申请日：1982-03-16

Applicant: DEGUSSA

Inventor： DRAUZ KARL HEINZ DIPL CHEM DR ,  KLEEMANN AXEL DIPL CHEM DR ,  WOLF-HEUSS ELISABETH DIPL CHEM

IPC: A01N43/08 ,  C07C67/00 ,  C07C253/00 ,  C07C255/17 ,  C07C255/31 ,  C07C255/32 ,  C07C255/40 ,  C07C255/45 ,  C07C255/56 ,  C07D307/54 ,  C07D307/68 ,  C07D333/24 ,  C07D333/38 ,  C07C121/76 ,  C07C121/34 ,  C07C121/46

Abstract: 3-oxonitriles are produced by reaction of carboxylic acid esters with carboxylic acid nitriles in the presence of 70 to 80% suspension of sodium hydride in white oil. The oxonitrile are intermediate products for the production of 3-oxocarboxylic acid amides or esters and pesticides.

公开(公告)号：DE3206225A1

公开(公告)日：1983-09-01

申请号：DE3206225

申请日：1982-02-20

Applicant: DEGUSSA

Inventor： SCHWARZE WERNER DIPL CHEM DR ,  KLEEMANN AXEL DIPL CHEM DR

IPC: A01N31/04 ,  C07C27/00 ,  C07C29/36 ,  C07C29/40 ,  C07C33/34 ,  C07C33/50 ,  C07C67/00

Abstract: There are prepared compounds of the general formula (I) where R is methyl or ethyl and R1 is halogen or hydrogen. The compounds are useful as fungicides, especially against Piricularia oryzae on rice.

公开(公告)号：DE3137376A1

公开(公告)日：1983-05-05

申请号：DE3137376

申请日：1981-09-19

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ DIPL CHEM DR ,  KLEEMANN AXEL DIPL CHEM DR

IPC: C07D205/04 ,  C07D207/16 ,  C07D211/60 ,  C07D211/62 ,  C07D277/06 ,  C07D279/06 ,  C07D279/12 ,  C07D471/04 ,  C07D487/04 ,  C07D223/08 ,  C07D225/00 ,  C07D281/00 ,  C07D281/02 ,  C07D281/04 ,  C07D281/18

公开(公告)号：DE2945497A1

公开(公告)日：1980-10-09

申请号：DE2945497

申请日：1979-11-10

Applicant: DEGUSSA

Inventor： BAKER DAVID H PROF ,  FAHNENSTICH RUDOLF DIPL CHEM D ,  KLEEMANN AXEL DIPL CHEM DR ,  LEHMANN BERND DIPL CHEM DR ,  MARTENS JUERGEN DIPL CHEM DR ,  TANNER HERBERT DIPL CHEM DR

IPC: A61K31/19 ,  A23K20060101 ,  A23K1/00 ,  A23K1/16 ,  A23K1/18 ,  A23K50/15 ,  A23L1/30 ,  A23L1/305 ,  A61K20060101 ,  A61K31/10 ,  A61K31/22 ,  A61P43/00 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C319/20 ,  C07C323/52 ,  C07C149/20