SALT CONVERSION AND PURIFICATION OF OLIGOPEPTIDE BY ONE PROCESS

    公开(公告)号:JPH11310595A

    公开(公告)日:1999-11-09

    申请号:JP8438699

    申请日:1999-03-26

    Applicant: DEGUSSA

    Abstract: PROBLEM TO BE SOLVED: To convert an oligopeptide to salt and to purify the salt by one process and to obtain an oligopeptide acetate by using an oligopeptide in the form of hydrochloride and subjecting the oligopeptide to liquid chromatography using an acetate-containing solvent. SOLUTION: In the method for salt conversion and purification of an oligopeptide by one process by a liquid chromatography using an acetate- containing solvent to obtain an oligopeptide acetate, the oligopeptide is used in its hydrochloride form for purification so that the oligopeptide is converted into a salt and purified by one process. Preferably a high-pressure liquid chromatography is used as the liquid chromatography, a solvent composed of a solvent A comprising 85-95% water, 2-10% acetic acid and 0-5% acetonitrile and a solvent B comprising 20-48% water, 2-10% acetic acid and 50-70% acetonitrile is used as a solvent base and the process is carried out at a temp of 5-50 deg.C under a pressure of 5-10 bar.

    7.
    发明专利
    未知

    公开(公告)号:DE102008013500A1

    公开(公告)日:2009-09-17

    申请号:DE102008013500

    申请日:2008-03-10

    Abstract: Chiral selectors having alpha-unsubstituted beta-amino acid derivatives of the structure: a stationary phase for separating substance mixtures containing the chiral selector, and processes for separating mixtures of chiral substances, including enantiomers, and especially enantiomers of substances selected from beta-amino acids and derivatives thereof, alpha-amino acids and alpha-hydroxy acids are provided.

    8.
    发明专利
    未知

    公开(公告)号:DE10333588A1

    公开(公告)日:2005-02-17

    申请号:DE10333588

    申请日:2003-07-24

    Applicant: DEGUSSA

    Abstract: The present invention focuses on a process for the hydrogenation of aromatic or heteroaromatic compounds and in particular on the ring hydrogenation of compounds having the formula (I). Aromatic amino acids and amino alcohols can be successfully ring-hydrogenated using a platinum-rhodium mixed catalyst. The products can be used inter alia as mimetics in bioactive peptide active ingredients.

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