Abstract:
PROBLEM TO BE SOLVED: To convert an oligopeptide to salt and to purify the salt by one process and to obtain an oligopeptide acetate by using an oligopeptide in the form of hydrochloride and subjecting the oligopeptide to liquid chromatography using an acetate-containing solvent. SOLUTION: In the method for salt conversion and purification of an oligopeptide by one process by a liquid chromatography using an acetate- containing solvent to obtain an oligopeptide acetate, the oligopeptide is used in its hydrochloride form for purification so that the oligopeptide is converted into a salt and purified by one process. Preferably a high-pressure liquid chromatography is used as the liquid chromatography, a solvent composed of a solvent A comprising 85-95% water, 2-10% acetic acid and 0-5% acetonitrile and a solvent B comprising 20-48% water, 2-10% acetic acid and 50-70% acetonitrile is used as a solvent base and the process is carried out at a temp of 5-50 deg.C under a pressure of 5-10 bar.
Abstract:
The invention relates to reaction tubes provided with catalyst coated inserts whose main faces are inclined at an angle equal to or less than 10° with respect to the longitudinal axis of a reaction tube, wherein said reaction tubes enable to attain an improved yield for a hydrogen cyanide production according to a BMA process without increased sooting in the reaction tubes.
Abstract:
Alcoholysis, hydrolysis or ammonolysis of phosphoric, phosphonic or carboxylic acid derivs. is effected by reaction with an alcohol, H2O or NH3 in the presence of an amidine base (I) and a metal cpd. (II).
Abstract:
The present invention focuses on a process for the hydrogenation of aromatic or heteroaromatic compounds and in particular on the ring hydrogenation of compounds having the formula (I). Aromatic amino acids and amino alcohols ca n be successfully ring-hydrogenated using a platinum-rhodium mixed catalyst. T he products can be used inter alia as mimetics in bioactive peptide active ingredients.
Abstract:
Synthetic oligopeptides are deprotected with concentrated hydrochloric acid (HCl) and the resulting hydrochlorides are simultaneously purified and converted into acetate form by liquid chromatography, using an acetate-containing eluant. A process for simultaneously desalting and purifying oligopeptides by liquid chromatography is new and uses an acetate-containing eluant to obtain the oligopeptide acetate, used in the form of its hydrochloride salt.
Abstract:
Chiral selectors having alpha-unsubstituted beta-amino acid derivatives of the structure: a stationary phase for separating substance mixtures containing the chiral selector, and processes for separating mixtures of chiral substances, including enantiomers, and especially enantiomers of substances selected from beta-amino acids and derivatives thereof, alpha-amino acids and alpha-hydroxy acids are provided.
Abstract:
The present invention focuses on a process for the hydrogenation of aromatic or heteroaromatic compounds and in particular on the ring hydrogenation of compounds having the formula (I). Aromatic amino acids and amino alcohols can be successfully ring-hydrogenated using a platinum-rhodium mixed catalyst. The products can be used inter alia as mimetics in bioactive peptide active ingredients.
Abstract:
The present invention relates to a process for the one-stage resalting and purification of oligopeptides. Oligopeptides are often not formed directly as acetates when synthesised. Acetate salts of oligopeptides are however desirable as bulk-active material for medical and formulation reasons. Processes known from the prior art have hitherto involved two separate steps or pyridine-containing solvents. According to the invention the resalting and purification can be combined in one step or the use of pyridine as solvent can be avoided, if the oligopeptide in the form of its chloride salt is purified with an acetate-containing solvent by liquid chromatography methods.
Abstract:
The present invention focuses on a process for the hydrogenation of aromatic or heteroaromatic compounds and in particular on the ring hydrogenation of compounds having the formula (I). Aromatic amino acids and amino alcohols can be successfully ring-hydrogenated using a platinum-rhodium mixed catalyst. The products can be used inter alia as mimetics in bioactive peptide active ingredients.