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公开(公告)号：WO0137783A3
公开(公告)日：2001-12-27
申请号：PCT/US0042084
申请日：2000-11-10
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： O'MARA KERRY DENNIS , KELLER DAVID , MCGINN JOSEPH THOMAS
IPC: B65G53/58 , A61K9/14 , B05B5/025 , B05B5/03 , B05B5/043 , B05B5/047 , B05B5/08 , B05B5/16 , B65G53/44 , B05B5/04
CPC classification number: B05B5/032 , B05B5/043 , B05B5/047 , B05B5/08 , B05B5/1683 , Y10S239/07 , Y10T137/2076 , Y10T137/2273
Abstract: A diffuser (518) comprises a conduit having a cross-sectional area that increases in a direction fluid flow. In one embodiment, the diffuser is used to reduce the incidence and severity of flow fluctuations that occur in an electrostatic deposition apparatus. In some embodiments, the diffuser includes one or more flow control features. A first flow-control feature comprises one or more appropriately-shaped annular slits (520) through which fluid having a greater momentum than a primary fluid moving through the diffuser is injected into the "boundary layer" near the wall of the diffuser. A second flow control feature comprises one or more annular slits (548) or, alternatively, slots or holes that are disposed at appropriate locations around the circumference of the diffuser through which a portion of fluid flowing in the boundary layer is removed. Boundary-layer flow removal is effected, in one embodiment, by creating a pressure differential across such annular slit or slots. Among other benefits, such flow control features reduce any tendencies for flow separation of the primary fluid in the diffuser.
Abstract translation: 扩散器（518）包括具有沿流体流动方向增加的横截面积的导管。 在一个实施例中，扩散器用于减少在静电沉积设备中发生的流动波动的发生率和严重性。 在一些实施例中，扩散器包括一个或多个流量控制特征。 第一流量控制特征包括一个或多个适当形状的环形狭缝（520），具有比通过扩散器移动的主要流体更大动量的流体通过该狭缝被注入到扩散器壁附近的“边界层”中。 第二流动控制特征包括一个或多个环形狭缝（548）或可选地设置在围绕扩散器的圆周的适当位置处的狭缝或孔，通过该狭缝或狭孔移除在边界层中流动的一部分流体。 在一个实施例中，通过在这样的环形狭缝或多个狭缝之间产生压差实现边界层流动移除。 除了其它益处之外，这种流量控制特征减少了扩散器中主流体的流动分离的任何倾向。
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公开(公告)号：AU755755B2
公开(公告)日：2002-12-19
申请号：AU1322800
申请日：1999-10-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHRAI SUGGY S , MCGINN JOSEPH THOMAS , SINGH BAWA
Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.
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公开(公告)号：CA2347978A1
公开(公告)日：2000-05-18
申请号：CA2347978
申请日：1999-10-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHRAI SUGGY S , MCGINN JOSEPH THOMAS , SINGH BAWA
Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the partic le tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-ti p. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomerati on and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are cover ed by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.
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公开(公告)号：NZ511414A
公开(公告)日：2003-11-28
申请号：NZ51141499
申请日：1999-10-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHRAI SUGGY S , MCGINN JOSEPH THOMAS , SINGH BAWA
Abstract: A method of depositing dielectric elongated pharmaceutical active medicament dry powder particles on a substrate comprising: Providing a plurality of dielectric elongated pharmaceutical active medicament dry particles each having a longitudinal axis; and Electrostatically depositing the particles on a surface of the substrate with the longitudinal axes aligned substantially normal to the substrate surface, the particles being attracted to the substrate by an electric field so as to minimize agglomeration of the particles and to minimize adherence of the particles to the substrate.
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公开(公告)号：HU0104759A2
公开(公告)日：2002-03-28
申请号：HU0104759
申请日：1999-10-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHRAI SUGGY S , MCGINN JOSEPH THOMAS , SINGH BAWA
Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.
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Patent Agency Ranking
公开(公告)号：AU1322800A
公开(公告)日：2000-05-29
申请号：AU1322800
申请日：1999-10-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHRAI SUGGY S , MCGINN JOSEPH THOMAS , SINGH BAWA
Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.
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公开(公告)号：AU4505201A
公开(公告)日：2001-06-04
申请号：AU4505201
申请日：2000-11-10
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： O'MARA KERRY DENNIS , KELLER DAVID , MCGINN JOSEPH THOMAS
IPC: B65G53/58 , A61K9/14 , B05B5/025 , B05B5/03 , B05B5/043 , B05B5/047 , B05B5/08 , B05B5/16 , B65G53/44
Abstract: A diffuser comprises a conduit having a cross-sectional area that increases in a direction fluid flow. In one embodiment, the diffuser is used to reduce the incidence and severity of flow fluctuations that occur in an electrostatic deposition apparatus. In some embodiments, the diffuser includes one or more flow control features. A first flow-control feature comprises one or more appropriately-shaped annular slits through which fluid having a greater momentum than a primary fluid moving through the diffuser is injected into the "boundary layer" near the wall of the diffuser. A second flow control feature comprises one or more annular slits or, alternatively, slots or holes that are disposed at appropriate locations around the circumference of the diffuser through which a portion of fluid flowing in the boundary layer is removed. Boundary-layer flow removal is effected, in one embodiment, by creating a pressure differential across such annular slit or slots. Among other benefits, such flow control features reduce any tendencies for flow separation of the primary fluid in the diffuser.
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公开(公告)号：CA2390462A1
公开(公告)日：2001-05-31
申请号：CA2390462
申请日：2000-11-10
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： KELLER DAVID , MCGINN JOSEPH THOMAS , O'MARA KERRY DENNIS
IPC: B65G53/58 , A61K9/14 , B05B5/025 , B05B5/03 , B05B5/043 , B05B5/047 , B05B5/08 , B05B5/16 , B65G53/44
Abstract: A diffuser (518) comprises a conduit having a cross-sectional area that increases in a direction fluid flow. In one embodiment, the diffuser is used to reduce the incidence and severity of flow fluctuations that occur in an electrostatic deposition apparatus. In some embodiments, the diffuser includ es one or more flow control features. A first flow-control feature comprises on e or more appropriately-shaped annular slits (520) through which fluid having a greater momentum than a primary fluid moving through the diffuser is injecte d into the "boundary layer" near the wall of the diffuser. A second flow contr ol feature comprises one or more annular slits (548) or, alternatively, slots o r holes that are disposed at appropriate locations around the circumference of the diffuser through which a portion of fluid flowing in the boundary layer is removed. Boundary-layer flow removal is effected, in one embodiment, by creating a pressure differential across such annular slit or slots. Among other benefits, such flow control features reduce any tendencies for flow separation of the primary fluid in the diffuser.
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公开(公告)号：PT1126891E
公开(公告)日：2004-03-31
申请号：PT99956676
申请日：1999-10-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： SINGH BAWA , CHRAI SUGGY S , MCGINN JOSEPH THOMAS
Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.
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公开(公告)号：AT256482T
公开(公告)日：2004-01-15
申请号：AT99956676
申请日：1999-10-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHRAI SUGGY S , MCGINN JOSEPH THOMAS , SINGH BAWA
Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.
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