公开(公告)号：WO9963972A9

公开(公告)日：2000-10-12

申请号：PCT/US9912772

申请日：1999-06-08

Applicant: DELSYS PHARMACEUTICAL CORP ,  CHEN JEN CHI ,  CHRAI SUGGY S ,  DESAI NITIN VITHALBHAI ,  HAMMER LAWRENCE HARRISON ,  KELLER DAVID ,  KUMAR NALIN ,  LAL PRINCE ,  LEVINE AARON WILLIAM ,  MURARI RAMASWAMY ,  MARA KERRY DENNIS O ,  POLINIAK EUGENE SAMUEL ,  RIVENBURG HOWARD CHRISTOPHER ,  ROACH WILLIAM RONALD ,  ROSATI DOMINIC STEPHEN ,  SINGH BAWA ,  SOUTHGATE PETER DAVID ,  SUN HOI CHEONG ,  ZANZUCCHI PETER JOHN

Inventor： CHEN JEN-CHI ,  CHRAI SUGGY S ,  DESAI NITIN VITHALBHAI ,  HAMMER LAWRENCE HARRISON ,  KELLER DAVID ,  KUMAR NALIN ,  LAL PRINCE ,  LEVINE AARON WILLIAM ,  MURARI RAMASWAMY ,  O'MARA KERRY DENNIS ,  POLINIAK EUGENE SAMUEL ,  RIVENBURG HOWARD CHRISTOPHER ,  ROACH WILLIAM RONALD ,  ROSATI DOMINIC STEPHEN ,  SINGH BAWA ,  SOUTHGATE PETER DAVID ,  SUN HOI CHEONG ,  ZANZUCCHI PETER JOHN

IPC: A61K9/14 ,  A61J1/03 ,  A61J3/00 ,  A61K9/16 ,  A61K9/51 ,  A61K9/70 ,  B05B5/025 ,  B05B5/08 ,  B05B5/16 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50

CPC classification number: A61K9/70 ,  A61J1/035 ,  A61J3/00 ,  B05B5/08 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50

Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.

Abstract translation: 本发明提供了一种产品（1），其包括药物单位剂量或诊断形式（6），其包含至少一种活性成分，其有效量不超过预定目标量的约5％ 。 在一个实施例中，单元形式包括衬底（8），设置在衬底上的沉积物（14）和覆盖在沉积物上的覆盖层（9），并且通过围绕该沉积物的键与衬底接合， 从而将其封装在基板和盖基板之间。 沉积物包含粉末，其中至少一些包括至少一种活性成分。 单元形式通过干粉沉积设备产生，其使用静电卡盘和带电粉末输送装置将粉末静电沉积在基底上。

公开(公告)号：WO0137783A3

公开(公告)日：2001-12-27

申请号：PCT/US0042084

申请日：2000-11-10

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： O'MARA KERRY DENNIS ,  KELLER DAVID ,  MCGINN JOSEPH THOMAS

IPC: B65G53/58 ,  A61K9/14 ,  B05B5/025 ,  B05B5/03 ,  B05B5/043 ,  B05B5/047 ,  B05B5/08 ,  B05B5/16 ,  B65G53/44 ,  B05B5/04

CPC classification number: B05B5/032 ,  B05B5/043 ,  B05B5/047 ,  B05B5/08 ,  B05B5/1683 ,  Y10S239/07 ,  Y10T137/2076 ,  Y10T137/2273

Abstract: A diffuser (518) comprises a conduit having a cross-sectional area that increases in a direction fluid flow. In one embodiment, the diffuser is used to reduce the incidence and severity of flow fluctuations that occur in an electrostatic deposition apparatus. In some embodiments, the diffuser includes one or more flow control features. A first flow-control feature comprises one or more appropriately-shaped annular slits (520) through which fluid having a greater momentum than a primary fluid moving through the diffuser is injected into the "boundary layer" near the wall of the diffuser. A second flow control feature comprises one or more annular slits (548) or, alternatively, slots or holes that are disposed at appropriate locations around the circumference of the diffuser through which a portion of fluid flowing in the boundary layer is removed. Boundary-layer flow removal is effected, in one embodiment, by creating a pressure differential across such annular slit or slots. Among other benefits, such flow control features reduce any tendencies for flow separation of the primary fluid in the diffuser.

Abstract translation: 扩散器（518）包括具有沿流体流动方向增加的横截面积的导管。 在一个实施例中，扩散器用于减少在静电沉积设备中发生的流动波动的发生率和严重性。 在一些实施例中，扩散器包括一个或多个流量控制特征。 第一流量控制特征包括一个或多个适当形状的环形狭缝（520），具有比通过扩散器移动的主要流体更大动量的流体通过该狭缝被注入到扩散器壁附近的“边界层”中。 第二流动控制特征包括一个或多个环形狭缝（548）或可选地设置在围绕扩散器的圆周的适当位置处的狭缝或孔，通过该狭缝或狭孔移除在边界层中流动的一部分流体。 在一个实施例中，通过在这样的环形狭缝或多个狭缝之间产生压差实现边界层流动移除。 除了其它益处之外，这种流量控制特征减少了扩散器中主流体的流动分离的任何倾向。

公开(公告)号：AU763869B2

公开(公告)日：2003-07-31

申请号：AU4675599

申请日：1999-06-08

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： CHEN JEN-CHI ,  CHRAI SUGGY S ,  DESAI NITIN VITHALBHAI ,  HAMMER LAWRENCE HARRISON ,  KELLER DAVID ,  KUMAR NALIN ,  LAL PRINCE ,  LEVINE AARON WILLIAM ,  MURARI RAMASWAMY ,  O'MARA KERRY DENNIS ,  POLINIAK EUGENE SAMUEL ,  RIVENBURG HOWARD CHRISTOPHER ,  ROACH WILLIAM RONALD ,  ROSATI DOMINIC STEPHEN ,  SINGH BAWA ,  SOUTHGATE PETER DAVID ,  SUN HOI CHEONG ,  ZANZUCCHI PETER JOHN

IPC: A61K9/14 ,  A61J1/03 ,  A61J3/00 ,  A61K9/16 ,  A61K9/51 ,  A61K9/70 ,  B05B5/025 ,  B05B5/08 ,  B05B5/16 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50

Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.

公开(公告)号：AU4675599A

公开(公告)日：1999-12-30

申请号：AU4675599

申请日：1999-06-08

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： CHEN JEN-CHI ,  CHRAI SUGGY S ,  DESAI NITIN VITHALBHAI ,  HAMMER LAWRENCE HARRISON ,  KELLER DAVID ,  KUMAR NALIN ,  LAL PRINCE ,  LEVINE AARON WILLIAM ,  MURARI RAMASWAMY ,  O'MARA KERRY DENNIS ,  POLINIAK EUGENE SAMUEL ,  RIVENBURG HOWARD CHRISTOPHER ,  ROACH WILLIAM RONALD ,  ROSATI DOMINIC STEPHEN ,  SINGH BAWA ,  SOUTHGATE PETER DAVID ,  SUN HOI CHEONG ,  ZANZUCCHI PETER JOHN

IPC: A61K9/14 ,  A61J1/03 ,  A61J3/00 ,  A61K9/16 ,  A61K9/51 ,  A61K9/70 ,  B05B5/025 ,  B05B5/08 ,  B05B5/16 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50

Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.

公开(公告)号：CA2333107A1

公开(公告)日：1999-12-16

申请号：CA2333107

申请日：1999-06-08

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： POLINIAK EUGENE SAMUEL ,  SINGH BAWA ,  RIVENBURG HOWARD CHRISTOPHER ,  SOUTHGATE PETER DAVID ,  SUN HOI CHEONG ,  ZANZUCCHI PETER JOHN ,  KUMAR NALIN ,  CHRAI SUGGY S ,  ROACH WILLIAM RONALD ,  DESAI NITIN VITHALBHAI ,  HAMMER LAWRENCE HARRISON ,  KELLER DAVID ,  CHEN JEN-CHI ,  O'MARA KERRY DENNIS ,  MURARI RAMASWAMY ,  LAL PRINCE ,  ROSATI DOMINIC STEPHEN ,  LEVINE AARON WILLIAM

IPC: A61K9/14 ,  A61J1/03 ,  A61J3/00 ,  A61K9/16 ,  A61K9/51 ,  A61K9/70 ,  B05B5/025 ,  B05B5/08 ,  B05B5/16 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50

Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit an d is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.

公开(公告)号：HU0203343A2

公开(公告)日：2003-02-28

申请号：HU0203343

申请日：2000-11-10

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： KELLER DAVID ,  MCGINN JOSEPH THOMAS ,  O'MARA KERRY DENNIS

IPC: A61K9/14 ,  B65G53/58 ,  B05B5/025 ,  B05B5/03 ,  B05B5/043 ,  B05B5/047 ,  B05B5/08 ,  B05B5/16 ,  B65G53/44 ,  B05B5/04

Abstract: A diffuser comprises a conduit having a cross-sectional area that increases in a direction fluid flow. In one embodiment, the diffuser is used to reduce the incidence and severity of flow fluctuations that occur in an electrostatic deposition apparatus. In some embodiments, the diffuser includes one or more flow control features. A first flow-control feature comprises one or more appropriately-shaped annular slits through which fluid having a greater momentum than a primary fluid moving through the diffuser is injected into the "boundary layer" near the wall of the diffuser. A second flow control feature comprises one or more annular slits or, alternatively, slots or holes that are disposed at appropriate locations around the circumference of the diffuser through which a portion of fluid flowing in the boundary layer is removed. Boundary-layer flow removal is effected, in one embodiment, by creating a pressure differential across such annular slit or slots. Among other benefits, such flow control features reduce any tendencies for flow separation of the primary fluid in the diffuser.

公开(公告)号：HU0102753A2

公开(公告)日：2001-11-28

申请号：HU0102753

申请日：1999-06-08

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： CHEN JEN-CHI ,  CHRAI SUGGY S ,  DESAI NITIN VITHALBHAI ,  HAMMER LAWRENCE HARRISON ,  KELLER DAVID ,  KUMAR NALIN ,  LAL PRINCE ,  LEVINE AARON WILLIAM ,  MURARI RAMASWAMY ,  O'MARA KERRY DENNIS ,  POLINIAK EUGENE SAMUEL ,  RIVENBURG HOWARD CHRISTOPHER ,  ROACH WILLIAM RONALD ,  ROSATI DOMINIC STEPHEN ,  SINGH BAWA ,  SOUTHGATE PETER DAVID ,  SUN HOI CHEONG ,  ZANZUCCHI PETER JOHN

IPC: A61K9/14 ,  A61J1/03 ,  A61J3/00 ,  A61K9/16 ,  A61K9/51 ,  A61K9/70 ,  B05B5/025 ,  B05B5/08 ,  B05B5/16 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50

Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.

公开(公告)号：NZ508402A

公开(公告)日：2003-08-29

申请号：NZ50840299

申请日：1999-06-08

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： ROSATI DOMINIC STEPHEN ,  SINGH BAWA ,  SOUTHGATE PETER DAVID ,  SUN HOI CHEONG ,  ZANZUCCHI PETER JOHN ,  ROACH WILLIAM RONALD ,  CHEN JEN-CHI ,  CHRAI SUGGY S ,  DESAI NITIN VITHALBHAI ,  HAMMER LAWRENCE HARRISON ,  KELLER DAVID ,  KUMAR NALIN ,  LAL PRINCE ,  LEVINE AARON WILLIAM ,  MURARI RAMASWAMY ,  O'MARA KERRY DENNIS ,  POLINIAK EUGENE SAMUEL ,  RIVENBURG HOWARD CHRISTOPHER

IPC: A61K9/14 ,  A61J1/03 ,  A61J3/00 ,  A61K9/16 ,  A61K9/51 ,  A61K9/70 ,  B05B5/025 ,  B05B5/08 ,  B05B5/16 ,  B65B1/04 ,  B65B1/30 ,  B65B11/50 ,  A61J3/02

Abstract: A dry powder deposition apparatus for depositing powder on a substrate comprises a deposition means for electrostatically depositing the powder at discrete locations on the substrate and an optical measurement device for nondestructively measuring the amount of powder deposited on the substrate. The powder comprises a pharmaceutically- or biologically active ingredient on a substrate and wherein. The deposition means comprises an electrostatic chuck wherein the electrostatic chuck has at least one collection zone. The collection zone is operable in conjunction with a bias source to generate a powder-attracting electrostatic field and the substrate is detachably engaged to the electrostatic chuck and overlies the collection zone.

公开(公告)号：AU4505201A

公开(公告)日：2001-06-04

申请号：AU4505201

申请日：2000-11-10

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： O'MARA KERRY DENNIS ,  KELLER DAVID ,  MCGINN JOSEPH THOMAS

IPC: B65G53/58 ,  A61K9/14 ,  B05B5/025 ,  B05B5/03 ,  B05B5/043 ,  B05B5/047 ,  B05B5/08 ,  B05B5/16 ,  B65G53/44

Abstract: A diffuser comprises a conduit having a cross-sectional area that increases in a direction fluid flow. In one embodiment, the diffuser is used to reduce the incidence and severity of flow fluctuations that occur in an electrostatic deposition apparatus. In some embodiments, the diffuser includes one or more flow control features. A first flow-control feature comprises one or more appropriately-shaped annular slits through which fluid having a greater momentum than a primary fluid moving through the diffuser is injected into the "boundary layer" near the wall of the diffuser. A second flow control feature comprises one or more annular slits or, alternatively, slots or holes that are disposed at appropriate locations around the circumference of the diffuser through which a portion of fluid flowing in the boundary layer is removed. Boundary-layer flow removal is effected, in one embodiment, by creating a pressure differential across such annular slit or slots. Among other benefits, such flow control features reduce any tendencies for flow separation of the primary fluid in the diffuser.

公开(公告)号：CA2390462A1

公开(公告)日：2001-05-31

申请号：CA2390462

申请日：2000-11-10

Applicant: DELSYS PHARMACEUTICAL CORP

Inventor： KELLER DAVID ,  MCGINN JOSEPH THOMAS ,  O'MARA KERRY DENNIS

IPC: B65G53/58 ,  A61K9/14 ,  B05B5/025 ,  B05B5/03 ,  B05B5/043 ,  B05B5/047 ,  B05B5/08 ,  B05B5/16 ,  B65G53/44

Abstract: A diffuser (518) comprises a conduit having a cross-sectional area that increases in a direction fluid flow. In one embodiment, the diffuser is used to reduce the incidence and severity of flow fluctuations that occur in an electrostatic deposition apparatus. In some embodiments, the diffuser includ es one or more flow control features. A first flow-control feature comprises on e or more appropriately-shaped annular slits (520) through which fluid having a greater momentum than a primary fluid moving through the diffuser is injecte d into the "boundary layer" near the wall of the diffuser. A second flow contr ol feature comprises one or more annular slits (548) or, alternatively, slots o r holes that are disposed at appropriate locations around the circumference of the diffuser through which a portion of fluid flowing in the boundary layer is removed. Boundary-layer flow removal is effected, in one embodiment, by creating a pressure differential across such annular slit or slots. Among other benefits, such flow control features reduce any tendencies for flow separation of the primary fluid in the diffuser.