公开(公告)号：US20230355802A1

公开(公告)日：2023-11-09

申请号：US18204436

申请日：2023-06-01

Applicant: Dalian Polytechnic University

Inventor： Mingqian TAN ,  Xue ZHAO ,  Xuedi ZHANG ,  Shanshan TIE ,  Jiyun CAO ,  Yun LI

IPC: A61K47/69 ,  A61K49/00 ,  A61P39/06 ,  A61K9/19 ,  A61K31/352 ,  A61P1/00

CPC classification number: A61K47/6939 ,  A61K9/19 ,  A61K31/352 ,  A61K49/0054 ,  A61K49/0093 ,  A61P1/00 ,  A61P39/06

Abstract: The disclosure provides marine polysaccharide vector-based anthocyanin nanoparticles, using marine polysaccharides, food-borne fluorescent nanoparticles and sodium hyaluronate as a composite vector to be combined with anthocyanin, and is prepared by a method: S1, dissolving sodium alginate in phosphate buffered saline, and successively adding EDC, HOBt and the food-borne fluorescent nanoparticles to obtain a fluorescence-alginate complex; S2, adding the fluorescence-alginate complex into a mixture of DMF and DCM, and then adding DIC and DMAP; S3, adding the anthocyanin and hyaluronic acid, and then removing a solvent; and S4, removing unreacted small molecules, and carrying out freeze drying. The disclosure can improve the anthocyanin stability, control the slow release of the anthocyanin, has the characteristics of fluorescent tracing, can be used as a fluorescent marker for in vivo imaging of animal tissues, organs, etc., and can also be delivered to animal colons in a targeted manner to alleviate DSS-induced colitis injury.