公开(公告)号：US08709232B2

公开(公告)日：2014-04-29

申请号：US13459455

申请日：2012-04-30

Applicant: David Matzinger

Inventor： David Matzinger

IPC: G01N27/26 ,  G01N33/50

CPC classification number: G01N27/3274

Abstract: Described are methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that highly accurate glucose concentration can be determined.

Abstract translation: 描述了将多个测试电压施加到测试条并测量由测试条的测试室中的电化学反应产生的电流瞬态输出的方法和系统，从而可以确定高精度的葡萄糖浓度。

公开(公告)号：US20050042135A1

公开(公告)日：2005-02-24

申请号：US10938965

申请日：2004-09-10

Applicant: David Matzinger ,  Khalid Quraishi ,  Yeung Yu

Inventor： David Matzinger ,  Khalid Quraishi ,  Yeung Yu

IPC: G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/558 ,  G01N33/66 ,  G01N21/00

CPC classification number: G01N33/558 ,  Y10S435/97 ,  Y10S436/808 ,  Y10S436/81

Abstract: Test strips for determining the concentration of at least one analyte, e.g., glucose, in a physiological sample and methods for their manufacture and use and are provided. The subject test strips include a transfer element for facilitating the transfer of sample to a reaction area of the test strip. In certain embodiments, the transfer element, typically porous, has a first area and a second area, and in certain embodiments the two areas have different thicknesses. In other embodiments, the transfer element is non-porous and is configured to transfer sample by wicking it between the transfer element and the reaction area of the test strip. In the subject methods, the transport element facilitates transfers of a sample to a reaction area of the test strip. The subject test strips and methods find use in a variety of different applications, particularly in the determination of glucose concentrations.

公开(公告)号：US20130034870A1

公开(公告)日：2013-02-07

申请号：US13198510

申请日：2011-08-04

Applicant: Khalid R. QURAISHI ,  David Matzinger

Inventor： Khalid R. QURAISHI ,  David Matzinger

IPC: C12Q1/54 ,  C12Q1/00 ,  G01N1/00

CPC classification number: G01N33/54386

Abstract: A method for the transfer of a bodily fluid sample (such as a whole blood sample) during the determination of an analyte (e.g., glucose) in the bodily fluid sample includes applying the bodily fluid sample to a sample collection reservoir of an analytical test strip (for example, an electrochemical-based analytical test strip). During such application, the sample collection reservoir is isolated from fluid communication with a determination chamber of the analytical test strip. The analytical test strip is subsequently inserted into a test meter such that the sample collection reservoir is placed into fluid communication with the determination chamber and such that at least a portion of the bodily fluid sample is consequentially transferred from the sample collection reservoir to the determination chamber. The method further includes determining the analyte in the bodily fluid sample transferred to the determination chamber.

Abstract translation: 在测定体液样品中的分析物（例如葡萄糖）时，用于转移体液样品（例如全血样品）的方法包括将体液样品施加到分析测试条的样品采集容器 （例如，基于电化学的分析测试条）。 在这种应用期间，样品收集容器与分析测试条的测定室的流体连通隔离。 分析测试条随后被插入到测试仪器中，使得样品收集容器被放置成与测定室流体连通，并且使得至少一部分体液样品从样品收集容器到确定室 。 该方法还包括确定转移到确定室的体液样品中的分析物。

公开(公告)号：US20050113717A1

公开(公告)日：2005-05-26

申请号：US10995688

申请日：2004-11-22

Applicant: David Matzinger ,  Khalid Quraishi

Inventor： David Matzinger ,  Khalid Quraishi

IPC: G01N33/48 ,  A61B5/00 ,  A61B5/026 ,  A61B5/103 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/15 ,  A61B5/157 ,  A61B10/00 ,  A61B17/00 ,  G01N33/487 ,  B65D81/00

CPC classification number: A61B5/441 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150748 ,  A61B5/150954 ,  A61B5/15107 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/157 ,  A61B5/489 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2017/00057 ,  G01N33/49 ,  G01N33/80

Abstract: Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable from the site, where the order of the above-described steps may be altered. The subject devices include at least one site flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.e., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sites in the fingers, arms, legs, earlobes, heels, feet, nose and toes. Also provided are kits that include the subject devices for use in practicing the subject methods.

Abstract translation: 提供了用于确定用于采样生理流体的合适位点的方法和装置。 在本方法中，选择潜在合适的生理取样部位，对该部位的流体流动进行表征，然后根据该部位是否具有高流量或低流量确定适合的部位。 也可以基于可从现场获得的样品的类型来确定适合性，其中可以改变上述步骤的顺序。 主题装置包括用于确定潜在生理取样部位的流动特征的至少一个位置流动表征元件和/或至少一个用于确定脉管系统是否是动脉，静脉或两者的样品类型表征元件，即组织液取样 现场。 主题方法和装置特别适用于检测手指，手臂，腿，耳垂，脚跟，鼻子和脚趾中的生理取样部位。 还提供了包括用于实践主题方法的主题装置的套件。

公开(公告)号：US08475733B2

公开(公告)日：2013-07-02

申请号：US13464450

申请日：2012-05-04

Applicant: David Matzinger

Inventor： David Matzinger

IPC: B01L9/06 ,  A61B5/00 ,  C12M1/34

CPC classification number: G01N33/4875 ,  Y10T436/25

Abstract: A hand-held test meter and analytical test strip cartridge assembly combination includes a hand-held test meter with a test meter housing and an extractor with a test strip engagement feature, while the analytical test strip cartridge assembly includes a desiccant vial and an analytical test strip cartridge with a cartridge housing, a test strip presentation mechanism disposed within the cartridge housing, and a plurality of analytical test strips (each with at least one extractor engagement feature) disposed in the cartridge housing. The test meter housing is configured for operative engagement with the cartridge housing and the test strip presentation mechanism is configured to present a single analytical test strip from the plurality of analytical test strips for engagement with the extractor. Moreover, the analytical test strip cartridge is configured for operative disposition in the desiccant vial.

Abstract translation: 手持测试仪和分析测试条组件组合包括具有测试仪表壳的手持式测试仪表和具有测试条接合特征的提取器，而分析测试条组件包括干燥剂小瓶和分析测试 具有盒壳体的带盒，设置在盒壳体内的测试条呈现机构，以及设置在盒壳体中的多个分析测试条（每个具有至少一个提取器接合特征）。 测试仪表壳被配置为与盒壳体有效接合，并且测试条呈现机构被配置为从多个分析测试条呈现单个分析测试条，用于与提取器接合。 此外，分析测试条盒配置为在干燥剂小瓶中的操作性配置。

公开(公告)号：US20060024835A1

公开(公告)日：2006-02-02

申请号：US10903108

申请日：2004-07-30

Applicant: David Matzinger ,  Sherry Guo ,  Khalid Quraishi

Inventor： David Matzinger ,  Sherry Guo ,  Khalid Quraishi

IPC: G01N31/22

CPC classification number: G01N33/558 ,  Y10T436/144444

Abstract: An analytical test strip for the determination of an analyte (e.g., glucose) in a liquid sample (such as whole blood) includes a matrix, with the matrix having a sample detection zone and a control zone(s). The sample detection zone includes a first reagent composition that reacts with analyte in the liquid sample to create a sample response and is configured to receive a first portion of the liquid sample. The control zone(s) includes a second reagent composition and is configured to receive another portion(s) of the liquid sample. In addition, the second reagent composition creates a predetermined control response when exposed to the second portion of the liquid sample. The predetermined control response, either alone or in combination with the sample response, can be employed to verify acceptable functioning of the analytical test strip and/or to provide a calibration factor for the analytical test strip.

Abstract translation: 用于测定液体样品（例如全血）中的分析物（例如葡萄糖）的分析测试条包括基质，该基质具有样品检测区和控制区。 样品检测区域包括与液体样品中的分析物反应以产生样品响应的第一试剂组合物，并且被配置为接收液体样品的第一部分。 控制区包括第二试剂组合物，并且构造成接收液体样品的另一部分。 此外，第二试剂组合物当暴露于液体样品的第二部分时产生预定的控制响应。 可以单独使用或与样品响应组合的预定控制响应来验证分析测试条的可接受的功能和/或为分析测试条提供校准因子。

公开(公告)号：US06939310B2

公开(公告)日：2005-09-06

申请号：US09974654

申请日：2001-10-10

Applicant: David Matzinger ,  Khalid R. Quraishi

Inventor： David Matzinger ,  Khalid R. Quraishi

IPC: G01N33/48 ,  A61B5/00 ,  A61B5/026 ,  A61B5/103 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/15 ,  A61B5/157 ,  A61B10/00 ,  A61B17/00 ,  G01N33/487 ,  B65D81/00

CPC classification number: A61B5/441 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150748 ,  A61B5/150954 ,  A61B5/15107 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/157 ,  A61B5/489 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2017/00057 ,  G01N33/49 ,  G01N33/80

Abstract: Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable from the site, where the order of the above-described steps may be altered. The subject devices include at least one site flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.e., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sites in the fingers, arms, legs, earlobes, heels, feet, nose and toes. Also provided are kits that include the subject devices for use in practicing the subject methods.

Abstract translation: 提供了用于确定用于采样生理流体的合适位点的方法和装置。 在本方法中，选择潜在合适的生理取样部位，对该部位的流体流动进行表征，然后根据该部位是否具有高流量或低流量确定适合的部位。 也可以基于可从现场获得的样品的类型来确定适合性，其中可以改变上述步骤的顺序。 主题装置包括用于确定潜在生理取样部位的流动特征的至少一个位置流动表征元件和/或用于确定脉管系统是否是动脉，静脉或两者的至少一个样品类型表征元件，即，间质液取样 现场。 主题方法和装置特别适用于检测手指，手臂，腿，耳垂，脚跟，鼻子和脚趾中的生理取样部位。 还提供了包括用于实践主题方法的主题装置的套件。

公开(公告)号：US06884592B2

公开(公告)日：2005-04-26

申请号：US09946215

申请日：2001-09-05

Applicant: David Matzinger ,  Khalid R. Quraishi ,  Yeung Siu Yu

Inventor： David Matzinger ,  Khalid R. Quraishi ,  Yeung Siu Yu

IPC: G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/558 ,  G01N33/66 ,  G01N33/53

CPC classification number: G01N33/558 ,  Y10S435/97 ,  Y10S436/808 ,  Y10S436/81

Abstract: Test strips for determining the concentration of at least one analyte, e.g., glucose, in a physiological sample and methods for their manufacture and use and are provided. The subject test strips include a transfer element for facilitating the transfer of sample to a reaction area of the test strip. In certain embodiments, the transfer element, typically porous, has a first area and a second area, and in certain embodiments the two areas have different thicknesses. In other embodiments, the transfer element is non-porous and is configured to transfer sample by wicking it between the transfer element and the reaction area of the test strip. In the subject methods, the transport element facilitates transfers of a sample to a reaction area of the test strip. The subject test strips and methods find use in a variety of different applications, particularly in the determination of glucose concentrations.

Abstract translation: 用于确定生理样品中至少一种分析物（例如葡萄糖）的浓度的测试条及其制备和使用方法。 主题测试条包括用于促进样品转移到测试条的反应区域的转移元件。 在某些实施方案中，转移元件通常为多孔的，具有第一区域和第二区域，并且在某些实施方案中，两个区域具有不同的厚度。 在其它实施方案中，转移元件是无孔的并且被配置为通过在转移元件和测试条的反应区域之间芯吸来移送样品。 在本发明的方法中，转运元件便于将样品转移到测试条的反应区域。 主题测试条和方法可用于各种不同的应用，特别是在葡萄糖浓度的测定中。

公开(公告)号：US09709521B2

公开(公告)日：2017-07-18

申请号：US14007234

申请日：2012-03-20

Applicant: David Matzinger ,  Maria Teodorczyk

Inventor： David Matzinger ,  Maria Teodorczyk

IPC: G01F1/64 ,  G01N27/26 ,  G01N27/327 ,  A61B5/145

CPC classification number: G01N27/3274 ,  A61B5/14532 ,  A61B2562/0295

Abstract: Methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that account for interferent substances in the body fluid sample. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter. The test meter has a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip.

公开(公告)号：US20140311924A1

公开(公告)日：2014-10-23

申请号：US14007234

申请日：2012-03-20

Applicant: David Matzinger ,  Maria Teodorczyk

Inventor： David Matzinger ,  Maria Teodorczyk

IPC: G01N27/327

CPC classification number: G01N27/3274 ,  A61B5/14532 ,  A61B2562/0295

Abstract: Methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that account for interferent substances in the body fluid sample. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter. The test meter has a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip.

Abstract translation: 将多个测试电压施加到测试条并测量由测试条的测试室中的电化学反应产生的电流瞬态输出的方法和系统，使得可以确定考虑体液中的干扰物质的葡萄糖浓度 样品。 一种使用包括测试条和测试仪的葡萄糖测量系统测定血糖浓度的方法。 测试仪具有被配置为向测试条施加多个测试电压并测量由测试条的测试室中的电化学反应产生的电流瞬态输出的微控制器。