公开(公告)号：US08709232B2

公开(公告)日：2014-04-29

申请号：US13459455

申请日：2012-04-30

Applicant: David Matzinger

Inventor： David Matzinger

IPC: G01N27/26 ,  G01N33/50

CPC classification number: G01N27/3274

Abstract: Described are methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that highly accurate glucose concentration can be determined.

Abstract translation: 描述了将多个测试电压施加到测试条并测量由测试条的测试室中的电化学反应产生的电流瞬态输出的方法和系统，从而可以确定高精度的葡萄糖浓度。

公开(公告)号：US20130034872A1

公开(公告)日：2013-02-07

申请号：US13464450

申请日：2012-05-04

Applicant: David MATZINGER

Inventor： David MATZINGER

IPC: C12Q1/54 ,  G01N1/28 ,  G01N33/50

CPC classification number: G01N33/4875 ,  Y10T436/25

Abstract: A hand-held test meter and analytical test strip cartridge assembly combination includes a hand-held test meter with a test meter housing and an extractor with a test strip engagement feature, while the analytical test strip cartridge assembly includes a desiccant vial and an analytical test strip cartridge with a cartridge housing, a test strip presentation mechanism disposed within the cartridge housing, and a plurality of analytical test strips (each with at least one extractor engagement feature) disposed in the cartridge housing. The test meter housing is configured for operative engagement with the cartridge housing and the test strip presentation mechanism is configured to present a single analytical test strip from the plurality of analytical test strips for engagement with the extractor. Moreover, the analytical test strip cartridge is configured for operative disposition in the desiccant vial.

Abstract translation: 手持测试仪和分析测试条组件组合包括具有测试仪表壳的手持式测试仪表和具有测试条接合特征的提取器，而分析测试条组件包括干燥剂小瓶和分析测试 具有盒壳体的带盒，设置在盒壳体内的测试条呈现机构，以及设置在盒壳体中的多个分析测试条（每个具有至少一个提取器接合特征）。 测试仪表壳被配置为与盒壳体有效接合，并且测试条呈现机构被配置为从多个分析测试条呈现单个分析测试条，用于与提取器接合。 此外，分析测试条盒配置为在干燥剂小瓶中的操作性配置。

公开(公告)号：US20050042135A1

公开(公告)日：2005-02-24

申请号：US10938965

申请日：2004-09-10

Applicant: David Matzinger ,  Khalid Quraishi ,  Yeung Yu

Inventor： David Matzinger ,  Khalid Quraishi ,  Yeung Yu

IPC: G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/558 ,  G01N33/66 ,  G01N21/00

CPC classification number: G01N33/558 ,  Y10S435/97 ,  Y10S436/808 ,  Y10S436/81

Abstract: Test strips for determining the concentration of at least one analyte, e.g., glucose, in a physiological sample and methods for their manufacture and use and are provided. The subject test strips include a transfer element for facilitating the transfer of sample to a reaction area of the test strip. In certain embodiments, the transfer element, typically porous, has a first area and a second area, and in certain embodiments the two areas have different thicknesses. In other embodiments, the transfer element is non-porous and is configured to transfer sample by wicking it between the transfer element and the reaction area of the test strip. In the subject methods, the transport element facilitates transfers of a sample to a reaction area of the test strip. The subject test strips and methods find use in a variety of different applications, particularly in the determination of glucose concentrations.

公开(公告)号：US09709521B2

公开(公告)日：2017-07-18

申请号：US14007234

申请日：2012-03-20

Applicant: David Matzinger ,  Maria Teodorczyk

Inventor： David Matzinger ,  Maria Teodorczyk

IPC: G01F1/64 ,  G01N27/26 ,  G01N27/327 ,  A61B5/145

CPC classification number: G01N27/3274 ,  A61B5/14532 ,  A61B2562/0295

Abstract: Methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that account for interferent substances in the body fluid sample. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter. The test meter has a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip.

公开(公告)号：US20140311924A1

公开(公告)日：2014-10-23

申请号：US14007234

申请日：2012-03-20

Applicant: David Matzinger ,  Maria Teodorczyk

Inventor： David Matzinger ,  Maria Teodorczyk

IPC: G01N27/327

CPC classification number: G01N27/3274 ,  A61B5/14532 ,  A61B2562/0295

Abstract: Methods and systems to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip so that a glucose concentration can be determined that account for interferent substances in the body fluid sample. A method of determining blood glucose concentration with a glucose measurement system that includes a test strip and test meter. The test meter has a microcontroller configured to apply a plurality of test voltages to the test strip and measure a current transient output resulting from an electrochemical reaction in a test chamber of the test strip.

Abstract translation: 将多个测试电压施加到测试条并测量由测试条的测试室中的电化学反应产生的电流瞬态输出的方法和系统，使得可以确定考虑体液中的干扰物质的葡萄糖浓度 样品。 一种使用包括测试条和测试仪的葡萄糖测量系统测定血糖浓度的方法。 测试仪具有被配置为向测试条施加多个测试电压并测量由测试条的测试室中的电化学反应产生的电流瞬态输出的微控制器。

公开(公告)号：US08580576B2

公开(公告)日：2013-11-12

申请号：US13198510

申请日：2011-08-04

Applicant: Khalid R. Quraishi ,  David Matzinger

Inventor： Khalid R. Quraishi ,  David Matzinger

IPC: G01N1/10

CPC classification number: G01N33/54386

Abstract: A method for the transfer of a bodily fluid sample (such as a whole blood sample) during the determination of an analyte (e.g., glucose) in the bodily fluid sample includes applying the bodily fluid sample to a sample collection reservoir of an analytical test strip (for example, an electrochemical-based analytical test strip). During such application, the sample collection reservoir is isolated from fluid communication with a determination chamber of the analytical test strip. The analytical test strip is subsequently inserted into a test meter such that the sample collection reservoir is placed into fluid communication with the determination chamber and such that at least a portion of the bodily fluid sample is consequentially transferred from the sample collection reservoir to the determination chamber. The method further includes determining the analyte in the bodily fluid sample transferred to the determination chamber.

Abstract translation: 在测定体液样品中的分析物（例如葡萄糖）时，用于转移体液样品（例如全血样品）的方法包括将体液样品施加到分析测试条的样品收集容器 （例如，基于电化学的分析测试条）。 在这种应用期间，样品收集容器与分析测试条的测定室的流体连通隔离。 分析测试条随后被插入到测试仪器中，使得样品收集容器被放置成与测定室流体连通，并且使得至少一部分体液样品从样品收集容器到确定室 。 该方法还包括确定转移到确定室的体液样品中的分析物。

公开(公告)号：US20130034871A1

公开(公告)日：2013-02-07

申请号：US13198536

申请日：2011-08-04

Applicant: David MATZINGER ,  Khalid R. Quraishi

Inventor： David MATZINGER ,  Khalid R. Quraishi

IPC: C12Q1/54 ,  C12M1/34

CPC classification number: G01N33/48757

Abstract: A hand-held test meter and analytical test strip cartridge combination includes a hand-held test meter with a test meter housing and an extractor with a test strip engagement feature, while the analytical test strip cartridge includes a cartridge housing, a test strip presentation mechanism disposed within the cartridge housing, and a plurality of analytical test strips (each with at least one extractor engagement feature) disposed in the cartridge housing. Moreover, the test meter housing is configured for operative engagement with the cartridge housing, the test strip presentation mechanism is configured to present a single analytical test strip from the plurality of analytical test strips for engagement with the extractor, and the extractor and test meter housing are configured such that the extractor is operatively extendable from the test meter housing into the cartridge housing upon engagement of the meter housing with the cartridge housing. In addition, the extractor is also configured such that, upon operative extension, the extractor mechanically engages with the analytical test strip presented by the test strip presentation mechanism via engagement between the test strip engagement feature and the extractor engagement feature, and such that, upon disengagement of the test meter housing from the cartridge housing, the extractor removes the mechanically engaged analytical test strip from the cartridge housing and retracts into the test meter housing.

Abstract translation: 手持式测试仪和分析测试条盒组合包括具有测试仪表壳体的手持测试仪表和具有测试条接合特征的提取器，而分析测试条带包括盒壳体，测试条呈现机构 设置在盒壳体内，以及设置在盒壳体中的多个分析测试条（每个具有至少一个提取器接合特征）。 此外，测试仪表壳被配置为与盒壳体有效接合，测试条呈现机构被配置为从多个分析测试条呈现单个分析测试条，用于与提取器接合，并且提取器和测试仪表壳体 配置成使得当仪表壳体与盒壳体接合时，提取器可操作地从测试仪表壳体延伸到盒壳体中。 此外，提取器还被构造成使得当操作延伸时，提取器通过测试条接合特征和提取器接合特征之间的接合机械地接合由测试条呈现机构呈现的分析测试条，并且使得在 测试仪表壳体与盒壳体的脱离接合，提取器将机械接合的分析测试条从盒壳体移除并缩回测试仪表壳体。

公开(公告)号：US20070207498A1

公开(公告)日：2007-09-06

申请号：US11513003

申请日：2006-08-30

Applicant: Stephen Palmieri ,  Dylan Bulseco ,  David Matzinger

Inventor： Stephen Palmieri ,  Dylan Bulseco ,  David Matzinger

IPC: G01N33/53 ,  C07K14/42

CPC classification number: G01N33/542 ,  C07K14/42

Abstract: Embodiments of the invention provide for compositions comprising purified polypeptides such as purified Concanavalin A (ConA) mutants. In addition, embodiments provide for polypeptides and nucleic acids encoding those polypeptides, such as mutant ConA with reduced dimer-dimer interactions compared to wild type ConA. Some embodiments also provide for sensors comprising the polypeptides disclosed herein. The embodiments also provide an improved method of producing recombinant mutant ConA.

Abstract translation: 本发明的实施方案提供包含纯化多肽的组合物，例如纯化的伴刀豆球蛋白A（ConA）突变体。 此外，实施方案提供编码那些多肽的多肽和核酸，例如与野生型ConA相比，具有降低的二聚体 - 二聚体相互作用的突变型ConA。 一些实施方案还提供包含本文公开的多肽的传感器。 实施方案还提供了重组突变型ConA的改良方法。

公开(公告)号：US07118916B2

公开(公告)日：2006-10-10

申请号：US10278167

申请日：2002-10-21

Applicant: David Matzinger

Inventor： David Matzinger

IPC: G01N33/00 ,  G01N21/01

CPC classification number: C12Q1/00 ,  G01N21/79 ,  G01N33/557 ,  G06F19/702 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/115831 ,  Y10T436/12 ,  Y10T436/144444 ,  Y10T436/147777 ,  Y10T436/171538

Abstract: Methods, devices and kits for facilitating medical diagnostic assays and reducing the time required for taking of such assays. The methods comprise initiating a reaction, obtaining at least three measurements, at three different time points, of a value or level of an observable associated with the reaction, and estimating an end point value for the observable from the measurements.

Abstract translation: 用于促进医学诊断测定和减少进行此类测定所需时间的方法，装置和试剂盒。 所述方法包括引发反应，在三个不同的时间点获得与反应相关的可观察值的值或水平的至少三个测量值，以及估计来自测量值的可观测值的终点值。

公开(公告)号：US07070564B2

公开(公告)日：2006-07-04

申请号：US10995688

申请日：2004-11-22

Applicant: David Matzinger ,  Khalid R. Quraishi

Inventor： David Matzinger ,  Khalid R. Quraishi

IPC: A61B5/00

CPC classification number: A61B5/441 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150748 ,  A61B5/150954 ,  A61B5/15107 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/157 ,  A61B5/489 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2017/00057 ,  G01N33/49 ,  G01N33/80

Abstract: Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable from the site, where the order of the above-described steps may be altered. The subject devices include at least one site flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.e., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sites in the fingers, arms, legs, earlobes, heels, feet, nose and toes. Also provided are kits that include the subject devices for use in practicing the subject methods.