公开(公告)号：US10173995B2

公开(公告)日：2019-01-08

申请号：US14760472

申请日：2014-01-11

Applicant: Dawei Zhang

Inventor： Dawei Zhang

IPC: C07D401/04 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/5355

Abstract: The present invention is directed to novel pyridines, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The present invention discloses compounds of Formulas I and II. The compounds and compositions of the present invention have protein kinases inhibitory activities and are expected to be useful for the treatment of protein kinases mediated diseases and conditions.

公开(公告)号：US09440227B2

公开(公告)日：2016-09-13

申请号：US13814645

申请日：2011-11-28

Applicant: Zhongtao Zhang ,  Yi Cheng ,  Xuli Zhai ,  Yong Jin ,  Jianzhong Li ,  Guizhi Wang ,  Zhixiang Zhang ,  Huimin Yuan ,  Fengrong Wang ,  Xianming Xu ,  Shubao Wan ,  Fangwei Li ,  Fengbo Ma ,  Jing Wei ,  Jina Zhao ,  Lijun Liu ,  Dawei Zhang

Inventor： Zhongtao Zhang ,  Yi Cheng ,  Xuli Zhai ,  Yong Jin ,  Jianzhong Li ,  Guizhi Wang ,  Zhixiang Zhang ,  Huimin Yuan ,  Fengrong Wang ,  Xianming Xu ,  Shubao Wan ,  Fangwei Li ,  Fengbo Ma ,  Jing Wei ,  Jina Zhao ,  Lijun Liu ,  Dawei Zhang

IPC: B01J37/08 ,  B01J23/755 ,  B01J37/02 ,  B01J37/34 ,  B01J21/04 ,  B01J23/46 ,  B01J35/00 ,  B01J37/00 ,  C01B3/40

CPC classification number: B01J37/08 ,  B01J21/04 ,  B01J23/464 ,  B01J23/755 ,  B01J35/0013 ,  B01J37/0045 ,  B01J37/0217 ,  B01J37/0225 ,  B01J37/023 ,  B01J37/349 ,  C01B3/40 ,  C01B2203/0233 ,  C01B2203/1058 ,  C01B2203/1064 ,  C01B2203/1082 ,  C01B2203/1241 ,  Y02P20/52

Abstract: A method for preparing catalyst coating on a metal base plate comprising: thermal-spraying a layer of α-aluminum oxide nano-particles on a metal base plate using a high temperature flame powder spray gun, at a temperature of 2500-3500° C. and a pressure of 0.2-1.2 MPa; coating an aluminum sol, the weight concentration of the aluminum sol aqueous solution being 2-30%, at a pH of 0.5-4, the drying temperature being 50-150° C., the drying time being 0.5-24 hours, the calcination temperature being 200-1200° C., and the calcination time being 0.5-24 hours; immersing in an active component, the immersing temperature being 20-120° C., the duration being 0.5-24 hours, the drying temperature being 50-150° C., the drying time being 0.5-24 hours, the calcination temperature being 200-1200° C., and the calcination time being 0.5-24 hours. The method is suitable for the preparation of various catalyst coatings with active components.

Abstract translation: 一种在金属基板上制备催化剂涂层的方法，包括：使用高温火焰粉末喷枪在2500-3500℃的温度下在金属底板上喷涂一层α-氧化铝纳米颗粒。 压力为0.2-1.2MPa; 涂覆铝溶胶，铝溶胶水溶液的重量浓度为2-30％，pH为0.5-4，干燥温度为50-150℃，干燥时间为0.5-24小时，煅烧 温度为200-1200℃，煅烧时间为0.5-24小时; 浸入活性成分中，浸渍温度为20-120℃，持续时间为0.5-24小时，干燥温度为50-150℃，干燥时间为0.5-24小时，煅烧温度为200℃ -1200℃，煅烧时间为0.5-24小时。 该方法适用于制备具有活性组分的各种催化剂涂料。

公开(公告)号：US20150353524A1

公开(公告)日：2015-12-10

申请号：US14760472

申请日：2014-01-11

Applicant: Dawei ZHANG

Inventor： Dawei Zhang

IPC: C07D401/04 ,  A61K45/06 ,  A61K31/5377

CPC classification number: C07D401/04 ,  A61K31/5355 ,  A61K31/5377 ,  A61K45/06

Abstract: The present invention is directed to novel pyridines, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The present invention discloses compounds of Formulas I and II. The compounds and compositions of the present invention have protein kinases inhibitory activities and are expected to be useful for the treatment of protein kinases mediated diseases and conditions.

Abstract translation: 本发明涉及新颖的吡啶类，其衍生物，药用盐，溶剂化物和水合物。 本发明公开了式I和II的化合物。 本发明的化合物和组合物具有蛋白激酶抑制活性，并且预期可用于治疗蛋白激酶介导的疾病和病症。

公开(公告)号：US08586739B2

公开(公告)日：2013-11-19

申请号：US13468212

申请日：2012-05-10

Applicant: Yi Chen ,  Timothy D. Cushing ,  Jason A. Duquette ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Xiao He ,  Brian S. Lucas ,  Lawrence R. McGee ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer L. Seganish ,  Youngsook Shin ,  Dawei Zhang

Inventor： Yi Chen ,  Timothy D. Cushing ,  Jason A. Duquette ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Xiao He ,  Brian S. Lucas ,  Lawrence R. McGee ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer L. Seganish ,  Youngsook Shin ,  Dawei Zhang

IPC: C07D487/04 ,  C07D473/34 ,  C07D241/40 ,  C07D241/44 ,  C07D215/14 ,  C07D215/26 ,  C07D215/22 ,  C07D417/14 ,  C07D417/04 ,  A61K31/52 ,  A61P35/00 ,  A61P19/02 ,  A61P37/06 ,  A61P19/08

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D473/30 ,  C07D473/34

Abstract: Substituted bicyclic heteroaryls having the general structure: and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid Leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

Abstract translation: 具有一般结构的取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症成分投诉，慢性 包括但不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏性疾病 。 本发明还使得能够治疗依赖于p110delta活性或与p110delta活性相关的癌症的方法，包括但不限于白血病，例如急性骨髓性白血病（AML）Myelo-dysplastic综合征（MDS）骨髓增生性疾病（MPD） 慢性骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

公开(公告)号：US08329910B2

公开(公告)日：2012-12-11

申请号：US13187188

申请日：2011-07-20

Applicant: Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

Inventor： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

IPC: C07D215/12

CPC classification number: C07D401/12 ,  C07D401/14

Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including nut not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

Abstract translation: 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状。 本发明还使得能够治疗依赖于p110δ活性或与p110δ活性相关的癌症的方法，包括不限于白血病的坚果，例如急性骨髓性白血病（AML）Myelo-dysplastic综合征（MDS）骨髓增殖性疾病（MPD） 慢性骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

公开(公告)号：US20110152277A1

公开(公告)日：2011-06-23

申请号：US13036236

申请日：2011-02-28

Applicant: Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

Inventor： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

IPC: A61K31/519 ,  C07D473/34 ,  A61K31/52 ,  A61P19/02 ,  A61P17/06 ,  A61P29/00 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D519/00

Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

Abstract translation: 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状 包括但不限于白血病，如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（MPD），介导，依赖或与p110δ活性相关的癌症的方法 （CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

公开(公告)号：US07897619B2

公开(公告)日：2011-03-01

申请号：US12218754

申请日：2008-07-16

Applicant: Qingping Zeng ,  Dawei Zhang ,  Guomin Yao ,  George E. Wohlhieter ,  Xianghong Wang ,  James Rider ,  Andreas Reichelt ,  Holger Monenschein ,  Fang-Tsao Hong ,  James R. Falsey ,  Celia Dominguez ,  Matthew P. Bourbeau ,  John G. Allen

Inventor： Qingping Zeng ,  Dawei Zhang ,  Guomin Yao ,  George E. Wohlhieter ,  Xianghong Wang ,  James Rider ,  Andreas Reichelt ,  Holger Monenschein ,  Fang-Tsao Hong ,  James R. Falsey ,  Celia Dominguez ,  Matthew P. Bourbeau ,  John G. Allen

IPC: A61K31/47 ,  A61K31/416 ,  C07D217/02 ,  C07D231/56

CPC classification number: C07D413/04 ,  C07D263/48 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04

Abstract: The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Abstract translation: 本发明涉及用于治疗由蛋白激酶B（PKB）介导的疾病的式I的杂环化合物及其组合物，其中变量具有本文提供的定义。 本发明还涉及这些化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。

公开(公告)号：US20070054916A1

公开(公告)日：2007-03-08

申请号：US11240590

申请日：2005-09-30

Applicant: Vinod Patel ,  Joseph Kim ,  Stephanie Geuns-Meyer ,  Stuart Chaffee ,  Victor Cee ,  Brian Hodous ,  Steven Bellon ,  Jean-Christophe Harmange ,  Philip Olivieri ,  Maya Thaman ,  Erin DiMauro ,  John Buchanan ,  David McGowan ,  Brian Albrecht ,  Holly Deak ,  Jean Bemis ,  Ryan White ,  Matthew Martin ,  Gregory Habgood ,  Paul Tempest ,  Craig Masse ,  William Buckner ,  Bradley Herberich ,  Russell Graceffa ,  Dawei Zhang ,  Shimin Xu ,  Kelvin Sham ,  Robert Rzasa ,  James Falsey ,  Partha Chakrabarti ,  Guo-Qiang Cao ,  Susan Tomlinson ,  Liping Pettus ,  Adrian Smith ,  Nick Paras ,  Gang Liu ,  Frenel DeMorin ,  Andrew Tasker ,  Anthony Reed

Inventor： Vinod Patel ,  Joseph Kim ,  Stephanie Geuns-Meyer ,  Stuart Chaffee ,  Victor Cee ,  Brian Hodous ,  Steven Bellon ,  Jean-Christophe Harmange ,  Philip Olivieri ,  Maya Thaman ,  Erin DiMauro ,  John Buchanan ,  David McGowan ,  Brian Albrecht ,  Holly Deak ,  Jean Bemis ,  Ryan White ,  Matthew Martin ,  Gregory Habgood ,  Paul Tempest ,  Craig Masse ,  William Buckner ,  Bradley Herberich ,  Russell Graceffa ,  Dawei Zhang ,  Shimin Xu ,  Kelvin Sham ,  Robert Rzasa ,  James Falsey ,  Partha Chakrabarti ,  Guo-Qiang Cao ,  Susan Tomlinson ,  Liping Pettus ,  Adrian Smith ,  Nick Paras ,  Gang Liu ,  Frenel DeMorin ,  Andrew Tasker ,  Anthony Reed

IPC: A61K31/525 ,  A61K31/519 ,  A61K31/517

CPC classification number: C07D215/38 ,  C07C205/37 ,  C07D215/12 ,  C07D217/12 ,  C07D217/22 ,  C07D217/26 ,  C07D239/26 ,  C07D239/84 ,  C07D239/94 ,  C07D239/95 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.

Abstract translation: 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症，癌症和相关病症的化合物。 化合物具有通式I，其中A 1，A 2，A 3，B，R 1， R 2，R 3和R 4在本文中定义。 因此，本发明还包括含有本发明化合物的药物组合物，使用本发明化合物和组合物预防和治疗激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

公开(公告)号：US06967254B2

公开(公告)日：2005-11-22

申请号：US10658298

申请日：2003-09-08

Applicant: Celia Dominguez ,  Dawei Zhang ,  Kelvin K. C. Sham ,  Guo-Qiang Cao

Inventor： Celia Dominguez ,  Dawei Zhang ,  Kelvin K. C. Sham ,  Guo-Qiang Cao

IPC: C07D401/04 ,  C07D401/14

CPC classification number: C07D401/04 ,  C07D401/14

Abstract: The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

Abstract translation: 本发明涉及具有通式的化合物或其药学上可接受的盐。 还包括预防或治疗炎症，类风湿性关节炎，斑节病，骨质疏松症，多发性骨髓瘤，葡萄膜炎，急性或慢性骨髓性白血病，胰腺β细胞破坏，骨关节炎，类风湿性脊椎炎，痛风性关节炎，炎性肠病，成人呼吸 窘迫综合征（ARDS），牛皮癣，克罗恩病，过敏性鼻炎，溃疡性结肠炎，过敏反应，接触性皮炎，哮喘，肌肉退化，恶病质，赖特综合征，I型糖尿病，II型糖尿病，骨吸收疾病，移植物抗宿主反应， 阿尔茨海默病，中风，心肌梗死，缺血再灌注损伤，动脉粥样硬化，脑外伤，多发性硬化，脑疟疾，败血症，败血性休克，中毒性休克综合征，发热，HIV-1，HIV-2，HIV-3，巨细胞病毒引起的肌痛 （CMV），流感，腺病毒，哺乳动物中的疱疹病毒或带状疱疹感染，包括给予有效量的化合物d 以上所述。

公开(公告)号：US09770704B2

公开(公告)日：2017-09-26

申请号：US14347052

申请日：2012-09-14

Applicant: Dawei Zhang

Inventor： Dawei Zhang

IPC: C10B1/10 ,  B01J20/34 ,  C10B53/04 ,  C10B47/30 ,  C10B57/02 ,  C10B39/00 ,  C02F1/28 ,  B01D53/26

CPC classification number: B01J20/3416 ,  B01D53/265 ,  C02F1/283 ,  C02F2303/16 ,  C10B1/10 ,  C10B39/00 ,  C10B47/30 ,  C10B53/04 ,  C10B57/02

Abstract: The present invention discloses a dust removing and coding method for an active coke regeneration apparatus. When the active coke regeneration apparatus is operating, the method includes the following: generating two negative pressure regions respectively at a discharge end and a feeding end; sucking out leaked vapor and dust by means of the negative regions; and cooling down the active coke regeneration apparatus by using gas flow generated by the negative pressure. Moreover, the present invention provides a device for implementing the method as described above.