公开(公告)号：CA2533926C

公开(公告)日：2013-10-15

申请号：CA2533926

申请日：2004-07-30

Applicant: ENDACEA INC

Inventor： WILSON CONSTANCE NEELY ,  BORRON PAUL

IPC: A61K39/00 ,  A01N43/04 ,  A01N43/42 ,  A61K31/70 ,  A61K39/385 ,  A61K39/39 ,  A61K39/40 ,  A61K39/42 ,  A61K39/44 ,  A61K45/00 ,  A61K47/00 ,  C07H19/04 ,  C07H19/20 ,  C12N20060101 ,  C12N5/0784

Abstract: The present invention relates to methods of producing an antigenic response in which an antigen is contacted to an antigen-presenting cell, wherein the improvement comprises contacting the antigen-presenting cell with an A1 adenosine receptor activating agent in an amount sufficient to increase the antigenic response of the antigen-presenting cell to the antigen. The present invention further provides methods, compositions, combination therapies, imaging techniques, and diagnostic kits that may improve the diagnosis, prognosis, and/or survival of cancer patients, pathogen-infected patients, and infectious or non-infectious immune-deficient patients.

公开(公告)号：CA2533926A1

公开(公告)日：2005-03-24

申请号：CA2533926

申请日：2004-07-30

Applicant: ENDACEA INC

Inventor： BORRON PAUL ,  WILSON CONSTANCE NEELY

IPC: A61K39/00 ,  A01N43/04 ,  A01N43/42 ,  A61K31/70 ,  A61K39/385 ,  A61K39/39 ,  A61K39/40 ,  A61K39/42 ,  A61K39/44 ,  A61K45/00 ,  A61K47/00 ,  C07H19/04 ,  C07H19/20 ,  C12N20060101 ,  C12N5/0784

Abstract: The present invention relates to methods of producing an antigenic response in which an antigen is contacted to an antigen-presenting cell, wherein the improvement comprises contacting the antigen-presenting cell with an A1 adenosine receptor activating agent in an amount sufficient to increase the antigenic response of the antigen-presenting cell to the antigen. The presen t invention further provides methods, compositions, combination therapies, imaging techniques, and diagnostic kits that may improve the diagnosis, prognosis, and/or survival of cancer patients, pathogen-infected patients, a nd infectious or non-infectious immune-deficient patients.

公开(公告)号：WO2005026318A2

公开(公告)日：2005-03-24

申请号：PCT/US2004024693

申请日：2004-07-30

Applicant: ENDACEA INC ,  WILSON CONSTANCE N ,  BORRON PAUL

Inventor： WILSON CONSTANCE N ,  BORRON PAUL

IPC: A01N43/04 ,  A01N43/42 ,  A61K31/70 ,  A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  A61K39/40 ,  A61K39/42 ,  A61K39/44 ,  A61K45/00 ,  A61K47/00 ,  C07H19/04 ,  C07H19/20 ,  C12N20060101 ,  C12N5/0784 ,  C12N

CPC classification number: C12N5/0639 ,  A61K39/39 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55516 ,  C12N5/064

Abstract: The present invention relates to methods of producing an antigenic response in which an antigen is contacted to an antigen-presenting cell, wherein the improvement comprises contacting the antigen-presenting cell with an A1 adenosine receptor activating agent in an amount sufficient to increase the antigenic response of the antigen-presenting cell to the antigen. The present invention further provides methods, compositions, combination therapies, imaging techniques, and diagnostic kits that may improve the diagnosis, prognosis, and/or survival of cancer patients, pathogen-infected patients, and infectious or non-infectious immune-deficient patients.

Abstract translation: 本发明涉及产生抗原应答的方法，其中抗原与抗原呈递细胞接触，其中改进包括使抗原呈递细胞与A1腺苷受体活化剂以足以增加抗原应答的量接触 的抗原呈递细胞。 本发明还提供了可以改善癌症患者，病原体感染的患者和感染性或非感染性免疫缺陷患者的诊断，预后和/或存活的方法，组合物，组合疗法，成像技术和诊断试剂盒。

公开(公告)号：EP1651259A4

公开(公告)日：2008-05-28

申请号：EP04816171

申请日：2004-07-30

Applicant: ENDACEA INC

Inventor： WILSON CONSTANCE N ,  BORRON PAUL

IPC: A61K39/00 ,  A01N43/04 ,  A01N43/42 ,  A61K31/70 ,  A61K39/385 ,  A61K39/39 ,  A61K39/40 ,  A61K39/42 ,  A61K39/44 ,  A61K45/00 ,  A61K47/00 ,  C07H19/04 ,  C07H19/20 ,  C12N20060101 ,  C12N5/0784

CPC classification number: C12N5/0639 ,  A61K39/39 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55516 ,  C12N5/064