公开(公告)号：WO2019215274A1

公开(公告)日：2019-11-14

申请号：PCT/EP2019/061903

申请日：2019-05-09

Applicant: FERROSAN MEDICAL DEVICES A/S ,  ETHICON INC.

Inventor： HAMMERSHØJ, Peter, Lund ,  LARSEN, Kristian ,  JOHNS, Douglas, B. ,  SMITH, Nicole ,  CARDINALE, Michael ,  FERRARA, Gabriella ,  ZHANG, Guanghui

IPC: A61L15/32 ,  A61L15/44 ,  A61L15/64

Abstract: The present disclosure relates to a method for preparing a haemostatic composition comprising thrombin, the method comprising the step of reconstituting a dry thrombin directly in a paste, such as a paste comprising a biocompatible polymer. The haemostatic composition comprising thrombin may be prepared from a dry thrombin composition and a paste in a single step operation and be used for treatment of a wound.

公开(公告)号：EP3790600A1

公开(公告)日：2021-03-17

申请号：EP19723388.5

申请日：2019-05-09

Applicant: Ferrosan Medical Devices A/S ,  Ethicon, Inc

Inventor： HAMMERSHØJ, Peter Lund ,  LARSEN, Kristian ,  JOHNS, Douglas B. ,  SMITH, Nicole ,  CARDINALE, Michael ,  FERRARA, Gabriella ,  ZHANG, Guanghui

IPC: A61L15/32 ,  A61L15/44 ,  A61L15/64

公开(公告)号：WO2022130103A1

公开(公告)日：2022-06-23

申请号：PCT/IB2021/061299

申请日：2021-12-03

Applicant: ETHICON, INC.

Inventor： DHANARAJ, Sridevi ,  GHODBANE, Salim ,  DEANGLIS, Ashley ,  CARDINALE, Michael ,  SMITH, Nicole ,  VISWANATH, Ashwin

IPC: A61K47/34 ,  A61L24/00 ,  A61L24/04 ,  A61L27/26 ,  C08L71/02

Abstract: A method of making a biocompatible composition for sealing tissue includes mixing a first fluid having a first reactive component (e.g., an electrophile) and a second fluid having a second reactive component (e.g., a nucleophile) to form a mixture and expressing the mixture. During expression, a pH modifying fluid (e.g., NaOH) is added to the mixture at a rate that changes. In one embodiment, a higher ratio of the pH modifying fluid is added to the mixture during a first expressing stage and a lower ratio of said pH modifying fluid is added to the mixture during a second expressing stage. During the first expressing stage, a mixing ratio of the pH modifying fluid, the first fluid and the second fluid is 0.7-1.4:1:1. During the second expressing stage, the mixing ratio of the pH modifying fluid, the first fluid and the second fluid is 0.12-0.24:1:1.

公开(公告)号：WO2018106406A1

公开(公告)日：2018-06-14

申请号：PCT/US2017/061273

申请日：2017-11-13

Applicant: ETHICON, INC.

Inventor： GUO, Jianxin ,  NORDMEYER, Michael ,  CARDINALE, Michael ,  COHN, Simon ,  KENYON, Mark D. ,  SOULS, Doug ,  FERREIRA, Danial Paul

IPC: A61B17/068

Abstract: An applicator instrument for dispensing surgical fasteners includes an elongated shaft, a housing connected with the elongated shaft, a trigger, a gear train, and a firing system disposed in the housing. The trigger is squeezed for commencing a firing cycle. The firing system includes a storage reel, a spool connected to the storage reel, a drive wheel located distal to the storage reel and the spool, a constant torque spring having a proximal end connected to the spool and a distal end connected to the drive wheel, and a flexible member in contact with the drive wheel. The flexible member has a proximal end connected to the storage reel and a length configured to be driven by the drive wheel toward the distal end of the elongated shaft. During an energy storing stage, the gear train is coupled with the storage reel for rotating the storage reel in a counterclockwise direction, which, in turn, retracts and winds the flexible member onto the storage reel, which rotates the drive wheel in a counterclockwise direction and winds the constant torque spring from the spool onto the drive wheel for storing energy in the constant torque spring.

公开(公告)号：WO2011155918A1

公开(公告)日：2011-12-15

申请号：PCT/US2010/033959

申请日：2010-05-07

Applicant: ETHICON, INC. ,  NERING, Robert ,  COHN, Simon ,  CARDINALE, Michael ,  FUCHS, Richard, P. ,  DANIEL, Matthew, David ,  JARRETT, Jeremy, David

Inventor： NERING, Robert ,  COHN, Simon ,  CARDINALE, Michael ,  FUCHS, Richard, P. ,  DANIEL, Matthew, David ,  JARRETT, Jeremy, David

IPC: A61B17/128 ,  A61B17/064 ,  A61B17/068 ,  A61F2/00

CPC classification number: A61B17/0682 ,  A61B17/064 ,  A61B2017/2923 ,  A61B2017/2946 ,  A61B2090/0807 ,  A61B2090/0814

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, an elongated shaft extending from the housing, a firing rod disposed inside the elongated shaft and being movable within a first plane between a retracted position and an extended position, an advancer disposed inside the elongated shaft and being moveable within a second plane between a retracted position and an extended position, and a staging assembly located adjacent the distal end of the elongated shaft and being adapted to align surgical fasteners with a distal end of the firing rod. The staging assembly is held below the second plane by the advancer when the advancer is in the extended position and the staging assembly is adapted to move into at least partial alignment with the distal end of the firing rod when the advancer is in the retracted position.

Abstract translation: 一种用于分配外科紧固件的施用器具包括壳体，从壳体延伸的细长轴，设置在细长轴内部的能够在缩回位置和伸出位置之间的第一平面内移动的击发杆，设置在细长轴内的推进器 并且可在缩回位置和延伸位置之间的第二平面内移动;以及分段组件，其位于所述细长轴的远端附近，并且适于将外科紧固件与所述发射杆的远端对准。 当推进器处于伸出位置时，分段组件由推进器保持在第二平面的下方，并且当推进器处于缩回位置时，分段组件适于移动至至少与击发杆的远端部分对准。

公开(公告)号：WO2010132281A1

公开(公告)日：2010-11-18

申请号：PCT/US2010/033960

申请日：2010-05-07

Applicant: ETHICON, INC. ,  DANIEL, Matthew, David ,  COHN, Simon ,  MIKSZA, Anthony ,  NERING, Robert ,  CARDINALE, Michael ,  FUCHS, Richard, P. ,  JARRETT, Jeremy, David

Inventor： DANIEL, Matthew, David ,  COHN, Simon ,  MIKSZA, Anthony ,  NERING, Robert ,  CARDINALE, Michael ,  FUCHS, Richard, P. ,  JARRETT, Jeremy, David

IPC: A61B17/064 ,  A61B17/068 ,  A61B17/128 ,  A61F2/00

CPC classification number: A61B17/0682 ,  A61B17/0401 ,  A61B17/064 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0464 ,  A61B2090/0807 ,  A61F2002/0072

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, an elongated shaft extending from the housing, the elongated shaft having a proximal end coupled with the housing and a distal end remote therefrom, and a firing system for dispensing surgical fasteners from the distal end of the elongated shaft. The firing system includes a firing rod disposed in the elongated shaft, the firing system having a firing cycle with a first stage for advancing the firing rod toward the distal end of the elongated shaft at a first rate of speed and a second stage for advancing the firing rod toward the distal end of the elongated shaft at a second rate of speed that is greater than the first rate of speed.

Abstract translation: 用于分配外科紧固件的施用器具包括壳体，从壳体延伸的细长轴，细长轴具有与壳体耦合的近端和远离其的远端，以及用于从远端远端分配外科紧固件的击发系统 细长的轴。 射击系统包括设置在细长轴中的发射杆，该射击系统具有击发循环，其具有第一阶段，用于以第一速度将击发杆朝向细长轴的远端推进，第二阶段用于推进 发射杆以大于第一速度速率的第二速度速度朝向细长轴的远端。

公开(公告)号：WO2018106412A2

公开(公告)日：2018-06-14

申请号：PCT/US2017/061286

申请日：2017-11-13

Applicant: ETHICON, INC.

Inventor： GUO, Jianxin ,  COHN, Simon ,  CARDINALE, Michael ,  SOULS, Doug ,  AUGUSTIN, Jephte

IPC: A61B17/064 ,  A61B17/068

Abstract: A surgical fastener includes a first leg having a first distal barb and a first proximal barb that extend inwardly, and a second leg having a second distal barb and a second proximal barb that extend inwardly. A bridge interconnects proximal ends of the first and second legs. A first distance between opposing inner tips of the first and second distal barbs is greater than a second distance between opposing inner tips of the first and second proximal barbs. The first leg tapers inwardly between the proximal and distal ends thereof and has a cross-sectional area that is greater at the proximal end than at the distal end. The second leg tapers inwardly between the proximal and distal ends thereof and has a cross-sectional area that is greater at the proximal end than at the distal end. An insertion tool engages a crown on the proximal side of the bridge.

公开(公告)号：WO2018022416A1

公开(公告)日：2018-02-01

申请号：PCT/US2017/043040

申请日：2017-07-20

Applicant: ETHICON, INC.

Inventor： GUO, Jianxin ,  COHN, Simon ,  CARDINALE, Michael ,  SOULS, Doug

IPC: A61F2/00

CPC classification number: A61F2/0063 ,  A61B1/313 ,  A61B17/06004 ,  A61B2017/00951 ,  A61F2002/0072 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0058 ,  A61F2250/0059

Abstract: Mesh implant positioning systems for use in laparoscopic body wall defect repairs, such as hernia defects, are disclosed. The systems utilize one or more bar members combined with surgical sutures and needles to position a mesh implant adjacent to a body wall defect without the need for stay sutures. Also disclosed are assemblies of the positioning systems with surgical mesh repair implants, and methods of repairing body wall defects such as hernias with the assemblies.

Abstract translation: 公开了用于腹腔镜体壁缺陷修复例如疝缺陷的网状植入物定位系统。 该系统利用与手术缝合线和针结合的一个或多个杆构件将网状植入物定位在体壁缺陷附近而不需要留置缝合线。 还公开了具有外科手术网修复植入物的定位系统的组件，以及用该组件修复诸如疝气之类的体壁缺陷的方法。

公开(公告)号：WO2017116745A1

公开(公告)日：2017-07-06

申请号：PCT/US2016/066922

申请日：2016-12-15

Applicant: ETHICON, INC.

Inventor： CARDINALE, Michael ,  SOULS, Doug ,  MIKSZA, Anthony ,  BRICKNER, Aaron J. ,  SCHNEIDER, Jared ,  SACK, Todd ,  SCHIFF, David R. ,  WENIG, Erin Elizabeth

IPC: A61B17/068 ,  A61F2/00 ,  A61B17/064 ,  A61B17/29 ,  A61B90/00

CPC classification number: A61F2/0063 ,  A61B17/064 ,  A61B17/0682 ,  A61B2017/2904 ,  A61B2017/2908 ,  A61B2017/2923 ,  A61B2017/2943 ,  A61B2090/0807 ,  A61F2002/0072

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, a firing system disposed in the housing, an actuator coupled with the housing for activating the firing system, an elongated shaft extending from the housing, the elongated shaft having a proximal end secured to the housing, a distal end, and a first axis extending between the proximal and distal ends, one or more surgical fasteners disposed in the elongated shaft, and a distal end cap secured to the distal end of the elongated shaft. The distal end cap has a surgical fastener dispensing window for dispensing the one or more surgical fasteners from the distal end cap. The firing system includes a firing rod that extends through the elongated shaft for dispensing the one or more surgical fasteners from the distal end cap. The firing rod has a proximal section that moves along the first axis of the elongated shaft and a distal section that moves along a second axis that defines an angle with the first axis.

Abstract translation: 用于分配手术紧固件的施用器械包括壳体，设置在壳体中的击发系统，与壳体联接用于致动击发系统的致动器，从壳体延伸的细长轴，细长轴 具有固定到壳体的近端，远端和在近端和远端之间延伸的第一轴线，设置在细长轴中的一个或多个外科紧固件以及紧固到细长轴的远端的远端盖 。 远端盖具有用于从远端盖分配一个或多个手术紧固件的外科紧固件分配窗口。 击发系统包括穿过细长轴延伸的发射杆，用于从远端帽分配一个或多个手术紧固件。 发射杆具有沿着细长轴的第一轴线移动的近侧部分和沿着与第一轴线限定角度的第二轴线移动的远侧部分。

公开(公告)号：WO2013170245A2

公开(公告)日：2013-11-14

申请号：PCT/US2013/040696

申请日：2013-05-13

Applicant: ETHICON, INC.

Inventor： CARDINALE, Michael ,  SOULS, Doug ,  COHN, Simon ,  GABEL, Jonathan B. ,  DANIEL, Matthew ,  FERREIRA, Danial Paul ,  SKULA, Emil Richard ,  TANNHAUSER, Robert J. ,  WORTHINGTON, Anthony

IPC: A61F2/00

CPC classification number: A61B1/018 ,  A61B17/064 ,  A61B17/0682 ,  A61B17/08 ,  A61B2017/003 ,  A61B2017/00455 ,  A61B2017/2905 ,  A61B2017/2923 ,  A61B2017/2946 ,  A61B2090/08021 ,  A61B2090/0807 ,  A61B2090/309 ,  A61B2090/3614 ,  A61B2090/373 ,  A61F2/0063

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, a firing system disposed in the housing and moveable in distal and proximal directions along a first axis, a handle extending upwardly from the housing along a second axis that defines an acute angle with the first axis, and a trigger mounted on the handle. The applicator instrument includes a non-linear elongated shaft extending from the housing that has a distal section that is extends upwardly toward a top of said applicator instrument. A distal end cap is secured to the distal end of the elongated shaft. The applicator has an imaging system including an imaging device for detecting images at the distal end of said applicator instrument, and a light source for illuminating a field of view for the imaging device at the distal end of the applicator instrument.

Abstract translation: 一种用于分配外科紧固件的施用器具包括壳体，设置在壳体中并且沿着第一轴线在远侧和近侧方向上可移动的击发系统，从壳体沿着与第一轴线限定锐角的第二轴向上延伸的手柄 ，以及安装在手柄上的触发器。 施用器械包括从壳体延伸的非线性细长轴，其具有朝向所述施用器械的顶部向上延伸的远侧部分。 远端帽固定到细长轴的远端。 施用器具有成像系统，该成像系统包括用于检测所述施用器械的远端处的图像的成像装置，以及用于在施用器械的远端照射成像装置的视野的光源。