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    MASS CYTOMETRY IMAGING
    1.
    发明申请
    MASS CYTOMETRY IMAGING 审中-公开
    大量细胞计数成像

    公开(公告)号：WO2016090356A1

    公开(公告)日：2016-06-09

    申请号：PCT/US2015/064226

    申请日：2015-12-07

    Applicant: FLUIDIGM CANADA INC.

    Inventor： LOBODA, Alexander V.

    IPC: H01J49/00 ,  G01N33/60 ,  G01N33/68 ,  H01J49/40 ,  G01N33/574

    CPC classification number: H01J49/105 ,  H01J49/0004 ,  H01J49/0463

    Abstract: The inventor has improved LA-ICP-MS to facilitate its use for imaging of biological samples. Additionally, mass cytometry systems having imaging capability less than 1 micron and high sensitivity are disclosed.

    Abstract translation: 发明人已经改进了LA-ICP-MS，以便于其用于生物样品的成像。 此外，公开了具有小于1微米和高灵敏度的成像能力的质量细胞计量系统。

    STRUCTURED BIOLOGICAL SAMPLES FOR ANALYSIS BY MASS CYTOMETRY
    4.
    发明申请
    STRUCTURED BIOLOGICAL SAMPLES FOR ANALYSIS BY MASS CYTOMETRY 审中-公开
    通过大量细胞分析分析的结构生物样品

    公开(公告)号：WO2016109825A1

    公开(公告)日：2016-07-07

    申请号：PCT/US2015/068330

    申请日：2015-12-31

    Applicant: FLUIDIGM CANADA INC.

    Inventor： LOBODA, Alexander V.

    IPC: C12M1/34 ,  G01N35/10 ,  H01J49/04

    CPC classification number: C12M25/00 ,  G01N1/286 ,  G01N33/4833 ,  G01N2001/045 ,  G01N2001/2886 ,  H01J49/0027 ,  H01J49/04

    Abstract: Apparatus and methods for delivering biological samples to an ICP source of a mass cytometer are disclosed. Biological material is disposed on a plurality of discrete sites on a carrier. The plurality of discrete sites are configured to retain biological material and to release the biological material upon application of energy. The carrier is positioned in proximity to a gas conduit and upon release from the discrete sites, the biological material becomes entrained in a gas flow, which delivers discrete portions of biological material through the conduit to the ICP source for analysis by mass cytometry. The apparatus and methods can provide a continuous stream of discrete portions of biological material to a mass cytometer.

    Abstract translation: 公开了将生物样品递送到质谱仪的ICP源的装置和方法。 生物材料被布置在载体上的多个离散位置上。 多个离散部位构造成保留生物材料并在施加能量时释放生物材料。 载体位于气体管道附近，并且在从离散位置释放时，生物材料被夹带在气流中，其将生物材料的离散部分通过导管输送到IC​​P源以通过质量细胞计量分析。 该装置和方法可以向质谱仪提供生物材料的分立部分的连续流。

    LASER ENABLED IMAGING MASS CYTOMETRY
    5.
    发明申请
    LASER ENABLED IMAGING MASS CYTOMETRY 审中-公开
    激光启动成像大量细胞计数

    公开(公告)号：WO2016126988A1

    公开(公告)日：2016-08-11

    申请号：PCT/US2016/016637

    申请日：2016-02-04

    Applicant: FLUIDIGM CANADA INC.

    Inventor： LOBODA, Alexander V. ,  BARANOV, Vladimir

    IPC: G01N33/53

    CPC classification number: H01J49/105 ,  G01N15/10 ,  G01N33/4833 ,  G01N2015/0065 ,  G01N2015/1006 ,  H01J49/0459 ,  H01J49/0463

    Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.

    Abstract translation: 本发明涉及使用激光烧蚀电感耦合等离子体质谱（LA-ICP-MS）分析样品的方法和装置。 本发明提供方法和装置，其中个体消融羽流被明显地捕获并转移到ICP，随后通过质谱法分析。

    MASS CYTOMETRY APPARATUS AND METHODS
    6.
    发明申请
    MASS CYTOMETRY APPARATUS AND METHODS 审中-公开
    大量细胞计数仪和方法

    公开(公告)号：WO2016109603A1

    公开(公告)日：2016-07-07

    申请号：PCT/US2015/067961

    申请日：2015-12-29

    Applicant: FLUIDIGM CANADA INC.

    Inventor： LOBODA, Alexander V. ,  BANDURA, Dmitry R. ,  BARANOV, Vladimir I.

    IPC: H01J49/26 ,  B01D59/44

    CPC classification number: G01N15/1056 ,  G01N2015/0065 ,  G01N2015/1006 ,  H01J49/0009 ,  H01J49/025 ,  H01J49/04 ,  H01J49/105 ,  H01J49/40

    Abstract: An improved mass cytometer to facilitate its use for the analysis of particles which may include a sampler, an ion source which is an inductively coupled plasma (ICP) from an ICP torch, wherein the ICP torch may comprise an injector that at the end of the injector proximal to the plasma has an internal diameter of less than 2 mm and more than 250 um, a mass spectrometer, an autosampler, an ion deflector, a dead-time corrector and a mass assignment corrector.

    Abstract translation: 改进的质谱仪便于其用于分析可能包括采样器的离子源，离子源，其来自ICP焊炬的电感耦合等离子体（ICP），其中ICP喷枪可以包括喷射器 等离子体附近的注射器具有小于2mm且大于250μm的内径，质谱仪，自动进样器，离子导流器，死区校正器和质量分配校正器。

    SAMPLE IMAGING APPARATUS AND METHOD
    7.
    发明申请
    SAMPLE IMAGING APPARATUS AND METHOD 审中-公开
    样品成​​像装置和方法

    公开(公告)号：WO2018026910A1

    公开(公告)日：2018-02-08

    申请号：PCT/US2017/045087

    申请日：2017-08-02

    Applicant: FLUIDIGM CANADA INC.

    Inventor： LOBODA, Alexander V.

    IPC: H01J49/04

    CPC classification number: H01J49/0463

    Abstract: Improved mass spectrometry-based apparatus and methods of analysis for analysing samples. A laser sampling system can be adapted to emit pulses of laser radiation at two or more wavelengths, wherein a first wavelength targets a first material and a second wavelength targets a second material. Atoms of the first and second materials removed by laser ablation are ionized by an ionisation system to form elemental ions, which can be detected by a mass spectrometer component. Laser ablation can be performed at multiple locations to form a plurality of plumes, which can be individually subjected to ionisation and spectrometry. Ablating at known locations or recording locational information for each location can permit construction of an image of the sample(s) based on detecting labelling atoms.

    Abstract translation: 改进的基于质谱仪的设备和用于分析样品的分析方法。 激光采样系统可以适用于发射两个或更多波长的激光辐射脉冲，其中第一波长以第一材料为目标，第二波长以第二材料为目标。 通过激光烧蚀去除的第一和第二材料的原子被离子化系统电离以形成元素离子，这可以被质谱仪部件检测到。 激光烧蚀可以在多个位置进行以形成多个羽流，其可以单独进行电离和光谱测定。 在已知位置消除或记录每个位置的位置信息可以允许基于检测标记原子构建样本图像。

    LASER ABLATION SYSTEM
    8.
    发明申请
    LASER ABLATION SYSTEM 审中-公开
    激光消融系统

    公开(公告)号：WO2018026898A1

    公开(公告)日：2018-02-08

    申请号：PCT/US2017/045060

    申请日：2017-08-02

    Applicant: FLUIDIGM CANADA INC.

    Inventor： LOBODA, Alexander V.

    IPC: H01J49/04

    Abstract: The invention relates to methods and devices for analysis of samples using laser ablation imaging mass cytometry and mass spectrometry. The invention provides methods and devices in which individual ablation plumes are distinctively captured and rapidly transferred to the ionization system, followed by analysis by mass spectrometry. A transfer conduit can be used to convey ablation plumes to an ionization system. The transfer conduit can include an asymmetric cone. The transfer conduit can be tapered. A flow sacrificing system can be adapted to divert a part of the sheath flow out a sacrificial outlet while the core of the sheath flow containing ablation plumes enters the ionization system.

    Abstract translation: 本发明涉及使用激光消融成像质量细胞计量术和质谱法分析样品的方法和装置。 本发明提供了各种方法和装置，其中单独的消融羽流被明显地捕获并迅速转移到电离系统中，随后通过质谱分析。 传输导管可用于将消融羽流传输至电离系统。 输送管道可以包括不对称锥体。 传输导管可以是锥形的。 流量牺牲系统可以适用于将鞘流的一部分转移出牺牲出口，同时包含消融羽流的鞘流的核心进入电离系统。

    STRUCTURED BIOLOGICAL SAMPLES FOR ANALYSIS BY MASS CYTOMETRY
    9.
    发明公开
    STRUCTURED BIOLOGICAL SAMPLES FOR ANALYSIS BY MASS CYTOMETRY 审中-公开

    公开(公告)号：EP4484950A3

    公开(公告)日：2025-03-12

    申请号：EP24212336.2

    申请日：2015-12-31

    Applicant: Fluidigm Canada Inc.

    Inventor： LOBODA, Alexander V.

    IPC: H01J49/04 ,  G01N33/483 ,  G01N1/04 ,  G01N1/28

    Abstract: Apparatus and methods for delivering biological samples to an ICP source of a mass cytometer are disclosed. Biological material is disposed on a plurality of discrete sites on a carrier. The plurality of discrete sites are configured to retain biological material and to release the biological material upon application of energy. The carrier is positioned in proximity to a gas conduit and upon release from the discrete sites, the biological material becomes entrained in a gas flow, which delivers discrete portions of biological material through the conduit to the ICP source for analysis by mass cytometry. The apparatus and methods can provide a continuous stream of discrete portions of biological material to a mass cytometer.

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