公开(公告)号：US09218949B2

公开(公告)日：2015-12-22

申请号：US13909721

申请日：2013-06-04

Applicant: FLUIDIGM CANADA INC.

Inventor： Scott D. Tanner

IPC: H01J49/40 ,  H01J49/02

CPC classification number: H01J49/40 ,  H01J49/025

Abstract: A mass spectrometer of the type useful in mass cytometry includes an ion detector. A digitizing system for converting analog signals from the ion detector includes two analog-to-digital converters. The analog-to-digital converters are configured to provide an increased dynamic range for a targeted period while limiting the amount of data generated.

Abstract translation: 用于质量分析的类型的质谱仪包括离子检测器。 用于转换离子检测器的模拟信号的数字化系统包括两个模拟 - 数字转换器。 模数转换器被配置为为目标周期提供增加的动态范围，同时限制所生成的数据量。

公开(公告)号：US09632079B2

公开(公告)日：2017-04-25

申请号：US14894287

申请日：2014-05-22

Applicant: FLUIDIGM CANADA INC.

Inventor： Dmitry R. Bandura ,  Vladimir I. Baranov ,  Alexander V. Loboda ,  Olga Ornatsky ,  Scott D. Tanner

IPC: G01N33/532 ,  G01N15/10 ,  H01J49/00 ,  G01N33/543 ,  G01N27/62 ,  G01N33/483 ,  G01N15/14

CPC classification number: G01N33/54366 ,  G01N15/1031 ,  G01N15/1404 ,  G01N15/1459 ,  G01N27/622 ,  G01N27/624 ,  G01N33/483 ,  G01N33/532 ,  G01N33/54313 ,  G01N2015/1006 ,  G01N2458/15

Abstract: The invention relates to methods and devices for molecular cytometry. The molecular cytometer is for use in the analysis of molecular tag labeled particles. In the molecular cytometer, volatile molecular tags attached to the particles, such as cells, are released as groups of molecular tags and ionized by the method of soft ionization to produce corresponding groups of molecular ions. The molecular cytometer has two detectors, one to detect the presence of the groups of molecular ions and the other to detect mobility separated molecular ions. The mobility separated molecular ions are synchronized to correspond with the groups of molecular ions.