中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

4 records (took 0.025 seconds)

    IMPROVED MASS CYTOMETRY
    1.
    发明申请
    IMPROVED MASS CYTOMETRY 审中-公开

    公开(公告)号：WO2020257258A1

    公开(公告)日：2020-12-24

    申请号：PCT/US2020/038097

    申请日：2020-06-17

    Applicant: FLUIDIGM CORPORATION ,  FLUIDIGM CANADA INC.

    Inventor： CORKUM, Paul ,  LOBODA, Alexander

    IPC: G01N27/62 ,  G01N15/10 ,  G01N21/71 ,  H01J49/04 ,  H01J49/26 ,  H01J49/40

    Abstract: Embodiments of the present invention relate to replacement of the previous ICP-based ionisation system with a new laser ionisation system, providing improved mass spectrometer-based apparatus and methods for using them to analyse samples, in particular the use of mass spectrometry mass cytometry, imaging mass spectrometry and imaging mass cytometry, for the analysis of biological samples. Accordingly, embodiments of the present invention provide an apparatus, for example a mass cytometer, comprising: 1 ) a sampler; 2) a laser ionisation system to receive material removed from the sample by the sampler, wherein the laser ionisation system comprises an ionisation system conduit and a pulsed laser adapted to ionise sample material passing through or exiting the ionisation system conduit; and 3) a mass spectrometer to receive elemental ions from said ionisation system and to analyse said elemental ions.

    HIGH RESOLUTION IMAGING APPARATUS AND METHOD
    2.
    发明申请
    HIGH RESOLUTION IMAGING APPARATUS AND METHOD 审中-公开

    公开(公告)号：WO2019246033A1

    公开(公告)日：2019-12-26

    申请号：PCT/US2019/037644

    申请日：2019-06-18

    Applicant: FLUIDIGM CANADA INC. ,  FLUIDIGM CORPORATION ,  CORKUM, Paul

    Inventor： CORKUM, Paul ,  LOBODA, Alexander

    IPC: H01J49/00 ,  H01J49/40 ,  G01N33/574 ,  G01N33/60 ,  G01N33/68 ,  G02B21/33 ,  G02B21/26 ,  G02B21/02

    Abstract: The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMCTM) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.

Patent Agency Ranking