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    DETERMINATION OF ANALYTES IN A SAMPLE MATRIX BY SOLVENT EXTRACTION
    1.
    发明申请
    DETERMINATION OF ANALYTES IN A SAMPLE MATRIX BY SOLVENT EXTRACTION 审中-公开
    通过溶剂萃取法确定样品基质中的分析物

    公开(公告)号：WO2016063104A1

    公开(公告)日：2016-04-28

    申请号：PCT/IB2014/065461

    申请日：2014-10-20

    Applicant: FOSS ANALYTICAL A/S

    Inventor： BISGAARD, Christer Zoffmann ,  DAHL, Malin ,  HOLM, Claus

    IPC: A23L1/015 ,  A23B9/00 ,  G01N1/40

    CPC classification number: G01N1/40 ,  A23L5/23 ,  B01D11/02 ,  B01D11/0203 ,  G01N1/34 ,  G01N1/4055 ,  G01N15/1012 ,  G01N15/1459 ,  G01N30/60 ,  G01N33/543 ,  G01N33/569 ,  G01N2001/2893 ,  G01N2001/4061 ,  G01N2015/1006 ,  G01N2015/1018 ,  G01N2030/009 ,  G01N2030/062

    Abstract: Determination of Analytes in a Sample Matrix by Solvent Extraction A method for the assay of one or more analytes in a sample matrix comprising the steps of: performing analyte extraction on the sample matrix, said analyte extraction comprising combining the sample matrix with a solvent for an extraction period which is less than that required for reaching equilibrium; and separating the analyte containing solvent from the sample matrix; next measuring a level of analyte present in the separated solvent; and then applying in a computer a calibration by which is established a mathematical relationship between levels of analyte extracted from each of a plurality of reference samples by means of the process employed above in the extraction for the sample matrix and a reference value of the levels of analyte for each reference sample to thereby derive a measure of the level of analyte in the sample matrix. Specifically a method to determine the amount of mycotoxins in cereal grain, especially OTA (ochratoxin A) and DON (deoxynivalenol) by mixing with a solvent comprising water alcohol mixture, with 20-40% ethanol by volume.

    Abstract translation: 通过溶剂萃取测定样品基质中的分析物一种用于测定样品基质中一种或多种分析物的方法，包括以下步骤：在样品基质上进行分析物提取，所述分析物提取包括将样品基质与溶剂组合，用于 提取时间小于达到平衡所需的时间; 并从样品基质中分离含有分析物的溶剂; 接下来测量分离的溶剂中存在的分析物的水平; 然后在计算机中应用校准，通过该校准建立了从多个参考样本中的每一个提取的分析物的水平之间的数学关系，借助于上述在样本矩阵的提取中使用的过程以及水平的参考值 分析物，从而得到样品基质中分析物水平的量度。 具体地说，一种通过与包含水醇混合物的溶剂与体积为20-40％乙醇的混合来测定谷粒中尤其是OTA（赭曲霉毒素A）和DON（脱氧雪腐镰刀菌烯醇）的霉菌毒素的量的方法。

    SYSTEM AND METHOD FOR CARRYING OUT ANALYSIS
    2.
    发明申请
    SYSTEM AND METHOD FOR CARRYING OUT ANALYSIS 审中-公开
    执行分析的系统和方法

    公开(公告)号：WO2009003730A1

    公开(公告)日：2009-01-08

    申请号：PCT/EP2008/051446

    申请日：2008-02-06

    Applicant: FOSS ANALYTICAL A/S ,  THOMSEN, Henrik ,  HOLM, Claus ,  BLAABJERG, Mette

    Inventor： THOMSEN, Henrik ,  HOLM, Claus ,  BLAABJERG, Mette

    IPC: G01N1/28 ,  G01N33/02 ,  G01N35/10

    CPC classification number: G01N1/286 ,  G01N35/1095 ,  G01N2001/2866

    Abstract: The invention relates to an automated system (100; 200) and a method (300; 400) for performing analysis on a sample. The sample may e.g. be of grain, foodstuff or feed and the analysis may be for measuring the concentration of one or more specific constituents which might affect the quality of the grain, foodstuff or feed. Such constituents could e.g. be mycotoxins, such as deoxynivalenol, zearalenone, ochratoxin, fumonisin, aflatoxin, and 1-2 toxin, and/or enzymes such as amylase in general, or alpha-amylase in specific. The system (100; 200) comprises containers (10; 12; 14; 16) for the sample and for liquids used during the measurements. The container (10) for the sample comprises grinding means (20) for grinding the sample and inlet means (11 ) for inletting solvent liquid from another container (12), preferably during the grinding so as to speed up the extraction of constituents from the first sample. The system (100, 200) moreover comprises a sensor (50) for measuring the concentration of the one or more specific constituents, which may be a biosensor or another type of biosensing system.

    Abstract translation: 本发明涉及一种用于对样本进行分析的自动化系统（100; 200）和方法（300; 400）。 样品可以例如。 是粮食，食品或饲料，分析可以用于测量可能影响谷物，食品或饲料质量的一种或多种特定成分的浓度。 这样的成分可以例如。 例如脱氧雪腐镰刀菌烯醇，玉米赤霉烯酮，赭曲霉毒素，伏马菌素，黄曲霉毒素和1-2毒素，和/或一般的淀粉酶等酶，特异性的α-淀粉酶等。 所述系统（100; 200）包括用于所述样品和在测量期间使用的液体的容器（10; 12; 14; 16）。 用于样品的容器（10）包括用于研磨样品的研磨装置（20）和用于从另一容器（12）引入溶剂液体的入口装置（11），优选在研磨期间加速从 第一个样本。 此外，系统（100,200）还包括用于测量一个或多个特定组分的浓度的传感器（50），其可以是生物传感器或另一种类型的生物传感系统。

    APPARATUS FOR DETERMINING COMPOSITIONAL PROPERTIES OF A MATERIAL
    4.
    发明授权
    APPARATUS FOR DETERMINING COMPOSITIONAL PROPERTIES OF A MATERIAL 有权

    公开(公告)号：EP1994396B1

    公开(公告)日：2018-06-13

    申请号：EP07704248.9

    申请日：2007-01-30

    Applicant: FOSS Analytical A/S

    Inventor： FRANDSEN, Anders Skaerlund ,  BORN, Christian ,  HOLM, Claus ,  THOMSEN, Henrik ,  LARSEN, Ole Brix

    IPC: G01N15/14

    CPC classification number: G01N15/1404 ,  G01N35/1095 ,  G01N2015/1409

    Abstract: An apparatus, such as a flow cytometer, for determining compositional properties of a material (38), comprises sensing means (24) having an output responsive to components of interest within a sample, here liquid (38), at a measurement location (22). A flow regulator, such as a pump (36), is provided in flow communication with the measurement location (22) and with the liquid sample (38). Control means (34) is adapted to analyse, such as by employment of an pulse height analyser (32), the output to determine a contribution thereto by noise and to control the operation of the flow regulator (36) to regulate presentation of the sample, here the flow rate, at the measurement location (22) in a manner dependent on the determined noise contribution.

    METHOD FOR DETERMINING A DEGREE OF INFECTION
    6.
    发明申请
    METHOD FOR DETERMINING A DEGREE OF INFECTION 审中-公开
    用于确定感染程度的方法

    公开(公告)号：WO2012052046A1

    公开(公告)日：2012-04-26

    申请号：PCT/EP2010/065615

    申请日：2010-10-18

    Applicant: FOSS ANALYTICAL A/S ,  HOLM, Claus

    Inventor： HOLM, Claus

    IPC: G01N33/50 ,  G01N33/569

    CPC classification number: C12Q1/06 ,  G01N33/5047 ,  G01N33/5091 ,  G01N33/582 ,  G01N2800/365

    Abstract: A method for determining a degree of infection comprising the steps of i) preparing an un-isolated sample by adding a differentiating marker, suitably a meta-chromatic stain such as, for example, acridine orange to mammalian milk in an amount sufficient to provide a differentiation between cell types; ii) measuring a differential somatic cell count on the sample by means of a cytometer having a detection system sensitive to differences in the differentiating marker resulting from the marker becoming differently associated with different cell types in the sample; and iii) determining an indication of a degree of infection dependent on the measured differential cell count.

    Abstract translation: 一种用于确定感染程度的方法，包括以下步骤：i）通过向哺乳动物乳添加适当的元色标记（例如吖啶橙）来制备未分离的样品，其量足以提供 细胞类型之间的分化; ii）通过具有检测系统的血细胞计数器来测量样品上的差异体细胞计数，所述检测系统对由所述标记变异与所述样品中的不同细胞类型不同相关的差异标记的差异敏感; 以及iii）确定取决于测量的差异细胞计数的感染程度的指示。

    SEPARATION OF PARTICLES IN LIQUIDS BY USE OF A STANDING ULTRASONIC WAVE
    7.
    发明申请
    SEPARATION OF PARTICLES IN LIQUIDS BY USE OF A STANDING ULTRASONIC WAVE 审中-公开
    通过使用超声波来分离液体中的颗粒

    公开(公告)号：WO2010040394A1

    公开(公告)日：2010-04-15

    申请号：PCT/EP2008/063434

    申请日：2008-10-08

    Applicant: FOSS Analytical A/S ,  HOLM, Claus ,  FOLKENBERG, Jacob Riis ,  GRENVALL, Carl Johan ,  LAURELL, Lars Thomas ,  AUGUSTSSON, Per

    Inventor： HOLM, Claus ,  FOLKENBERG, Jacob Riis ,  GRENVALL, Carl Johan ,  LAURELL, Lars Thomas ,  AUGUSTSSON, Per

    IPC: B01D43/00 ,  B01L3/00

    CPC classification number: B01D21/283 ,  B01L3/502761 ,  B01L2300/0816 ,  B01L2300/0877 ,  C12M47/06 ,  G01N15/12 ,  G01N15/1459 ,  G01N33/06

    Abstract: The invention relates to a device for manipulation of particles (30) in a sample liquid (32) said device comprising a source of ultrasound (16) capable of emitting ultrasound with a given wavelength, an inlet for a sample liquid (2), one or more outlets (4, 5, 6) and a compartment (14), being dimensioned to support a standing ultrasonic wave (40) of said wavelength, characterised in that the device further comprises an inlet for sheath liquid (1, 3) configured to direct a sheath liquid (34) to extend substantially in parallel to an anti-node plane (46) of the ultrasonic standing wave (40) proximate to a sheathed compartment wall. Specifically the device may be used in combination with a particle enumeration device for enumeration of somatic cells in milk.

    Abstract translation: 本发明涉及一种用于操纵样品液体（32）中的颗粒（30）的装置，所述装置包括能够发射具有给定波长的超声波的超声波源（16），用于样品液体的入口（2），一个 或多个出口（4,5,6）和隔室（14），其尺寸被设计成支撑所述波长的立式超声波（40），其特征在于，所述装置还包括用于鞘液（1,3）的入口配置 引导护套液体（34）基本上平行于超声波驻波（40）的靠近护套隔室壁的反节点平面（46）延伸。 具体地，该装置可以与用于计数牛奶中体细胞的颗粒计数装置组合使用。

    APPARATUS FOR DETERMINING COMPOSITIONAL PROPERTIES OF A MATERIAL
    8.
    发明申请
    APPARATUS FOR DETERMINING COMPOSITIONAL PROPERTIES OF A MATERIAL 审中-公开
    用于测定材料组成特性的装置

    公开(公告)号：WO2007104602A1

    公开(公告)日：2007-09-20

    申请号：PCT/EP2007/050896

    申请日：2007-01-30

    Applicant: FOSS ANALYTICAL A/S ,  FRANDSEN, Anders Skaerlund ,  BORN, Christian ,  HOLM, Claus ,  THOMSEN, Henrik ,  LARSEN, Ole Brix

    Inventor： FRANDSEN, Anders Skaerlund ,  BORN, Christian ,  HOLM, Claus ,  THOMSEN, Henrik ,  LARSEN, Ole Brix

    IPC: G01N15/14

    CPC classification number: G01N15/1404 ,  G01N35/1095 ,  G01N2015/1409

    Abstract: Apparatus for Determining Compositional Properties of a Material An apparatus, such as a flow cytometer, for determining compositional properties of a material (38), comprises sensing means (24) having an output responsive to components of interest within a sample, here liquid (38), at a measurement location (22). A flow regulator such as a pump (36) is provided in flow communication with the measurement location (22) and with the liquid sample (38). Control means (34) is adapted to analyse, such as by employment of an pulse height analyser (32), the output to determine a contribution thereto by noise and to control the operation of the flow regulator (36) to regulate presentation of the sample, here the flow rate, at the measurement location (22) in a manner dependent on the determined noise contribution.

    Abstract translation: 用于确定材料的组成性质的装置用于确定材料（38）的组成性质的装置，例如流式细胞仪，包括感测装置（24），其具有响应于样品内的感兴趣组分的输出，这里是液体（38 ），在测量位置（22）。 设置有诸如泵（36）的流量调节器与测量位置（22）和液体样品（38）流动连通。 控制装置（34）适于例如通过使用脉冲高度分析器（32）来分析输出以确定噪声对其的贡献，并且控制流量调节器（36）的操作以调节样品的显示 ，这里是以取决于所确定的噪声贡献的方式在测量位置（22）处的流量。

    METHOD FOR DETERMINING A DEGREE OF INFECTION
    10.
    发明公开
    METHOD FOR DETERMINING A DEGREE OF INFECTION 有权
    用于确定感染乳腺炎的度数

    公开(公告)号：EP2630487A1

    公开(公告)日：2013-08-28

    申请号：EP10768012.6

    申请日：2010-10-18

    Applicant: FOSS Analytical A/S

    Inventor： HOLM, Claus

    IPC: G01N33/50 ,  G01N33/569

    CPC classification number: C12Q1/06 ,  G01N33/5047 ,  G01N33/5091 ,  G01N33/582 ,  G01N2800/365

    Abstract: A method for determining a degree of infection comprising the steps of i) preparing an un-isolated sample by adding a differentiating marker, suitably a meta-chromatic stain such as, for example, acridine orange to mammalian milk in an amount sufficient to provide a differentiation between cell types; ii) measuring a differential somatic cell count on the sample by means of a cytometer having a detection system sensitive to differences in the differentiating marker resulting from the marker becoming differently associated with different cell types in the sample; and iii) determining an indication of a degree of infection dependent on the measured differential cell count.

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