Patent search ap:("FUJIFILM CORP") AND inv:"MATSUMOTO TAKUYA" Page 1

1.

发明专利
Sal de compuesto heterocíclico que contiene nitrógeno o cristal del mismo, composición farmacéutica e inhibidor de FLT3 未知

公开(公告)号：ES2738573T3

公开(公告)日：2020-01-23

申请号：ES14854750

申请日：2014-10-15

Applicant: FUJIFILM CORP

Inventor： MIZUMOTO SHINSUKE , MATSUMOTO TAKUYA

IPC: C07D239/48 , A61K31/505 , A61P35/02 , A61P43/00

Abstract: Una sal del ácido carboxílico (carboxilato) o una sal de ácido mineral de (S,E)-N-(1-((5-(2-((4-cianofenil)amino)-4- (propilamino)pirimidin-5-il)pent-4-in-1-il)amino)-1-oxopropan-2-il)-4-(dimetilamino)-N-metilbut-2-enamida, en donde el carboxilato es formiato, acetato, lactato, benzoato, citrato, oxalato, fumarato, maleato, succinato, malato, tartrato, aspartato, tricloroacetato, trifluoroacetato o pamoato y la sal de ácido mineral es clorhidrato, bromhidrato, yodhidrato, nitrato, fosfato o sulfato.

2.

发明专利
1-(2-DEOKSI-2-FLUOR-4-TIO-BETA-D-ARABINOFURANOZIL)CITOZINO SINTEZĖS TARPINIAI JUNGINIAI, TIONUKLEOZIDO SINTEZĖS TARPINIAI JUNGINIAI IR ŠIŲ TARPINIŲ JUNGINIŲ GAMYBOS BŪDAI 未知

公开(公告)号：LT2883866T

公开(公告)日：2019-05-10

申请号：LT13879640

申请日：2013-08-13

Applicant: FUJIFILM CORP

Inventor： NAKAMURA KOUKI , SHIMAMURA SATOSHI , IMOTO JUNICHI , TAKAHASHI MOTOMASA , WATANABE KATSUYUKI , WADA KENJI , FUJINO YUUTA , MATSUMOTO TAKUYA , TAKAHASHI MAKOTO , OKADA HIDEKI , YAMANE TAKEHIRO , ITO TAKAYUKI

IPC: C07C69/618 , A61K31/7068 , C07B53/00 , C07C45/00 , C07C67/29 , C07C68/06 , C07C69/28 , C07C69/76 , C07C69/78 , C07C69/92 , C07C69/96 , C07C303/28 , C07C309/73 , C07D333/32 , C07H13/04 , C07H13/08 , C07H15/04 , C07H15/18 , C07H15/203 , C07H17/02

3.

发明专利
SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-.BETA.-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THE SAME 未知

公开(公告)号：CA2880794C

公开(公告)日：2018-08-28

申请号：CA2880794

申请日：2013-08-13

Applicant: FUJIFILM CORP

Inventor： NAKAMURA KOUKI , SHIMAMURA SATOSHI , IMOTO JUNICHI , TAKAHASHI MOTOMASA , WATANABE KATSUYUKI , WADA KENJI , FUJINO YUUTA , MATSUMOTO TAKUYA , TAKAHASHI MAKOTO , OKADA HIDEKI , YAMANE TAKEHIRO , ITO TAKAYUKI

IPC: C07H19/06 , A61K31/7068 , C07B53/00 , C07D333/32 , C07H5/02 , C07H5/10 , C07H19/04

Abstract: A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside. (see above formula)

4.

发明专利
SALT OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR CRYSTAL THEREOF, PHARMACEUTICAL COMPOSITION, AND FLT3 INHIBITOR 未知

公开(公告)号：CA2927079C

公开(公告)日：2017-05-23

申请号：CA2927079

申请日：2014-10-15

Applicant: FUJIFILM CORP

Inventor： MIZUMOTO SHINSUKE , MATSUMOTO TAKUYA

IPC: C07D239/48 , A61K31/505 , A61P35/02 , A61P43/00

Abstract: The present invention addresses the problem of providing: a compound exhibiting excellent stability and/or solubility and the like, and further improved FLT3 inhibitory activity; and a pharmaceutical composition. The present invention provides a salt or crystal of (S,E)-N-(1-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidine-5-yl)pent-4-yne-1-yl)amino)-1-oxopropane-2-yl)-4-(dimethylamino)-N-methylbuto-2-enamide (compound A). This salt or crystal thereof exhibits excellent FLT3 inhibitory activity, and excellent properties as a drug such as storage stability, solubility, or the like; hence, said salt or crystal thereof is useful in treating a disease or a condition pertaining to FLT3. The present invention provides a pharmaceutical composition and an FLT3 inhibitor which contain this salt or the crystal thereof.

5.

发明专利
Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same 未知

公开(公告)号：AU2013303534B2

公开(公告)日：2016-06-30

申请号：AU2013303534

申请日：2013-08-13

Applicant: FUJIFILM CORP

Inventor： NAKAMURA KOUKI , SHIMAMURA SATOSHI , IMOTO JUNICHI , TAKAHASHI MOTOMASA , WATANABE KATSUYUKI , WADA KENJI , FUJINO YUUTA , MATSUMOTO TAKUYA , TAKAHASHI MAKOTO , OKADA HIDEKI , YAMANE TAKEHIRO , ITO TAKAYUKI

IPC: C07C45/00 , A61K31/7068 , A61P35/00 , C07B53/00 , C07C47/277 , C07C249/04 , C07C251/38 , C07C303/28 , C07C309/73 , C07H5/02 , C07H5/10 , C07H19/06

Abstract: A compound represented by general formula [1D] (in the formula, R

6.

发明公开
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND SALT OR CRYSTAL THEREOF, PHARMACEUTICAL COMPOSITION, AND FLT3 INHIBITOR 审中-公开
Title translation: 氮杂环化合物，其盐或晶体，药物组合物和FLT3抑制剂

公开(公告)号：EP3059227A4

公开(公告)日：2016-09-07

申请号：EP14854750

申请日：2014-10-15

Applicant: FUJIFILM CORP

Inventor： MIZUMOTO SHINSUKE , MATSUMOTO TAKUYA

IPC: C07D239/48 , A61K31/505 , A61P35/02 , A61P43/00

CPC classification number: C07D239/48 , A61K31/505 , C07B2200/13 , C07C55/10 , C07C57/15 , C07C65/11 , C07C309/29 , C07D239/42

Abstract: An object of the present invention is to provide a compound and pharmaceutical composition showing superior stability and/or solubility, etc. and having superior FLT3 inhibitory activity. The present invention provides a salt of (S,E)-N-(1-((5-(2-((4-cyanophenyl)ammo)-4-(propylanmio)pyrimidin-5-yl)pent-4-yn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methylbut-2-enamide, or a crystal thereof. Since the salt or a crystal thereof has superior FLT3 inhibitory activity and shows superior physicochemical properties as drugs, such as storage stability, solubility, and so forth, it is useful for treatments of diseases or conditions relating to FLT3. The present invention also provides a pharmaceutical composition and FLT3 inhibitor containing the salt or a crystal thereof.

7.

发明公开
INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-beta-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES 审中-公开
Title translation: 中间体1-（2-脱氧-2-氟-4-硫代-β-D-阿拉伯呋喃糖）合成胞嘧啶，中间体的硫代核苷生产这种中间体的合成和方法

公开(公告)号：EP2883866A4

公开(公告)日：2016-06-15

申请号：EP13879640

申请日：2013-08-13

Applicant: FUJIFILM CORP

Inventor： NAKAMURA KOUKI , SHIMAMURA SATOSHI , IMOTO JUNICHI , TAKAHASHI MOTOMASA , WATANABE KATSUYUKI , WADA KENJI , FUJINO YUUTA , MATSUMOTO TAKUYA , TAKAHASHI MAKOTO , OKADA HIDEKI , YAMANE TAKEHIRO , ITO TAKAYUKI

IPC: C07C251/38 , A61K31/7068 , A61P35/00 , C07B53/00 , C07C45/00 , C07C47/277 , C07C249/04 , C07C303/28 , C07C309/73 , C07H5/02 , C07H5/10 , C07H19/06

CPC classification number: C07D333/32 , A61K31/7068 , C07B53/00 , C07C45/00 , C07C47/277 , C07C67/29 , C07C68/06 , C07C69/28 , C07C69/618 , C07C69/76 , C07C69/78 , C07C69/92 , C07C69/96 , C07C249/04 , C07C251/38 , C07C251/40 , C07C303/28 , C07C309/66 , C07C309/73 , C07F7/1844 , C07H1/00 , C07H7/04 , C07H13/04 , C07H13/08 , C07H15/04 , C07H15/18 , C07H15/203 , C07H17/02 , C07H19/06 , C07H19/067 , C07H19/073 , C07H23/00 , Y02P20/55

Abstract: A compound represented by a formula [ID] as shown below (wherein R 1A , R 1B , R 2A , R 2B , R 3A and R 3B represent a hydrogen atom, an optionally substituted C 1-6 alkyl group, and the like) is useful as an intermediate for producing a thionucleoside, and the production method of the present invention is useful as a method for producing a thionucleoside.

8.

发明专利
Intermedier l-(2-deoxi-2-fluor-4-tio-beta-D-arabinofuranozil)-citozin szintézisére, intermedier tionukleozid szintézisére és eljárások ezen intermedierek elõállítására 未知

公开(公告)号：HUE044412T2

公开(公告)日：2019-10-28

申请号：HUE13879640

申请日：2013-08-13

Applicant: FUJIFILM CORP

Inventor： NAKAMURA KOUKI , SHIMAMURA SATOSHI , IMOTO JUNICHI , TAKAHASHI MOTOMASA , WATANABE KATSUYUKI , WADA KENJI , FUJINO YUUTA , MATSUMOTO TAKUYA , TAKAHASHI MAKOTO , OKADA HIDEKI , YAMANE TAKEHIRO , ITO TAKAYUKI

IPC: C07B53/00 , C07C45/00 , C07C67/29 , C07C68/06 , C07C69/28 , C07C69/76 , C07C69/78 , C07C69/92 , C07C69/96 , C07H13/04 , C07H13/08 , C07H15/04 , C07H15/18 , C07H17/02

9.

发明专利
INTERMEDIJER ZA SINTEZU 1-(2-DEOKSI-2-FLUORO-4-TIO-BETA-D-ARABINOFURANOZIL) CITOZINA, INTERMEDIJER ZA SINTEZU TIONUKLEOZIDA, I METODE ZA PROIZVODNJU OVIH INTERMEDIJERA 未知

公开(公告)号：RS58568B1

公开(公告)日：2019-05-31

申请号：RSP20190409

申请日：2013-08-13

Applicant: FUJIFILM CORP

Inventor： NAKAMURA KOUKI , SHIMAMURA SATOSHI , IMOTO JUNICHI , TAKAHASHI MOTOMASA , WATANABE KATSUYUKI , WADA KENJI , FUJINO YUUTA , MATSUMOTO TAKUYA , TAKAHASHI MAKOTO , OKADA HIDEKI , YAMANE TAKEHIRO , ITO TAKAYUKI

IPC: C07C69/618 , A61K31/7068 , C07B53/00 , C07C45/00 , C07C67/29 , C07C68/06 , C07C69/28 , C07C69/76 , C07C69/78 , C07C69/92 , C07C69/96 , C07C303/28 , C07C309/73 , C07D333/32 , C07H13/04 , C07H13/08 , C07H15/04 , C07H15/18 , C07H15/203 , C07H17/02

10.

发明专利
SÓL HETEROCYKLICZNEGO ZWIĄZKU ZAWIERAJĄCEGO AZOT LUB JEJ KRYSZTAŁ, KOMPOZYCJA FARMACEUTYCZNA I INHIBITOR FLT3 未知

公开(公告)号：PL3059227T3

公开(公告)日：2019-11-29

申请号：PL14854750

申请日：2014-10-15

Applicant: FUJIFILM CORP

Inventor： MIZUMOTO SHINSUKE , MATSUMOTO TAKUYA

IPC: C07D239/48 , A61K31/505 , A61P35/02 , A61P43/00

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