公开(公告)号：EP1097944A4

公开(公告)日：2004-03-31

申请号：EP99928210

申请日：1999-07-06

Applicant: FUSO PHARMACEUTICAL IND

Inventor： YAMAMOTO HIROSHI ,  TSUJIKAWA KAZUTAKE ,  UCHINO YUKIKO

IPC: C07K16/40 ,  C12N5/20 ,  C12N15/06 ,  C12P21/08 ,  G01N33/573 ,  C12N15/12 ,  C07K14/72 ,  C12N9/12

CPC classification number: C07K16/40 ,  G01N33/573 ,  G01N2333/916

Abstract: An antibody specific to intracellular domains of at least two protein tyrosine phosphatases; a process for preparing the same; and cells producing the above antibody. This antibody, which has specificities to intracellular domains of both of phosphatase subunits LAR and CD45, is useful in analyzing and quantitating PTPs, identifying and detecting a novel PTP, acquiring a novel phosphatase by cloning, etc., as well as developing a diagnostic method useful in insulin resistance and NIDDM, preventing, treating (curing, etc.) and diagnosing various symptoms of syndrome X based on insulin resistance, and preventing and diagnosing the onset of arteriosclerosis and heart diseases.

公开(公告)号：EP1092772A4

公开(公告)日：2004-07-07

申请号：EP99923958

申请日：1999-06-07

Applicant: FUSO PHARMACEUTICAL IND

Inventor： YAMAMOTO HIROSHI ,  TSUJIKAWA KAZUTAKE ,  UCHINO YUKIKO ,  KONISHI NOBORU

IPC: A61K38/00 ,  A61K39/395 ,  C07K14/72 ,  C07K16/40 ,  C12N1/20 ,  C12N5/20 ,  C12N9/12 ,  C12N15/12 ,  C12P21/08 ,  G01N33/573 ,  G01N33/574

CPC classification number: C12N9/1205 ,  A61K38/00 ,  C07K14/72 ,  C07K16/40 ,  G01N33/573

Abstract: An antibody specific for LAR phosphatase subunit, in particular, the intracellular domain of LAR phosphatase subunit; a process for producing the same; cells producing the above antibody; a method for quantitating and examining LAR/LAR-derived molecules by using this antibody; and utilization of this antibody in diagnosing and treating thyroid cancer.

公开(公告)号：AT411386T

公开(公告)日：2008-10-15

申请号：AT99928210

申请日：1999-07-06

Applicant: FUSO PHARMACEUTICAL IND

Inventor： YAMAMOTO HIROSHI ,  TSUJIKAWA KAZUTAKE ,  UCHINO YUKIKO

IPC: C12N15/12 ,  C07K14/72 ,  C07K16/40 ,  C12N5/20 ,  C12N9/12 ,  C12N15/06 ,  C12P21/08 ,  G01N33/573

Abstract: Antibodies to intracellular domains of two or more kinds of protein tyrosine phosphatases, methods for generation thereof and cells producing these antibodies are disclosed. The antibody of the present invention may have specificity to intracellular domains of phosphatase subunits of both of LAR and CD45, and may be useful for analysis and quantitative determination of PTPs, identification and detection of novel PTPs, and for obtaining novel phosphatases by cloning and the like, as well as for developing useful diagnostic methods of insulin resistance and NIDDM, for prophylaxis and diagnosis of various disease states of syndrome X that is based on insulin resistance, and for prophylaxis and diagnosis of onsets of arteriosclerosis and cardiac diseases.

公开(公告)号：DE69936780D1

公开(公告)日：2007-09-20

申请号：DE69936780

申请日：1999-06-07

Applicant: FUSO PHARMACEUTICAL IND

Inventor： YAMAMOTO HIROSHI ,  TSUJIKAWA KAZUTAKE ,  UCHINO YUKIKO ,  KONISHI NOBORU

IPC: C12N15/12 ,  A61K38/00 ,  A61K39/395 ,  C07K14/72 ,  C07K16/40 ,  C12N1/20 ,  C12N5/20 ,  C12N9/12 ,  C12P21/08 ,  G01N33/573 ,  G01N33/574

Abstract: Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.

公开(公告)号：AT369425T

公开(公告)日：2007-08-15

申请号：AT99923958

申请日：1999-06-07

Applicant: FUSO PHARMACEUTICAL IND

Inventor： YAMAMOTO HIROSHI ,  TSUJIKAWA KAZUTAKE ,  UCHINO YUKIKO ,  KONISHI NOBORU

IPC: C12N15/12 ,  A61K38/00 ,  A61K39/395 ,  C07K14/72 ,  C07K16/40 ,  C12N1/20 ,  C12N5/20 ,  C12N9/12 ,  C12P21/08 ,  G01N33/573 ,  G01N33/574

Abstract: Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.

公开(公告)号：AU751340B2

公开(公告)日：2002-08-15

申请号：AU4531799

申请日：1999-07-06

Applicant: FUSO PHARMACEUTICAL IND

Inventor： YAMAMOTO HIROSHI ,  TSUJIKAWA KAZUTAKE ,  UCHINO YUKIKO

IPC: C07K16/40 ,  C12N5/20 ,  C12N15/06 ,  C12P21/08 ,  G01N33/573 ,  C07K16/18 ,  G01N33/53 ,  G01N33/577

Abstract: Antibodies to intracellular domains of two or more kinds of protein tyrosine phosphatases, methods for generation thereof and cells producing these antibodies are disclosed. The antibody of the present invention may have specificity to intracellular domains of phosphatase subunits of both of LAR and CD45, and may be useful for analysis and quantitative determination of PTPs, identification and detection of novel PTPs, and for obtaining novel phosphatases by cloning and the like, as well as for developing useful diagnostic methods of insulin resistance and NIDDM, for prophylaxis and diagnosis of various disease states of syndrome X that is based on insulin resistance, and for prophylaxis and diagnosis of onsets of arteriosclerosis and cardiac diseases.

公开(公告)号：CA2329776A1

公开(公告)日：1999-12-16

申请号：CA2329776

申请日：1999-06-07

Applicant: FUSO PHARMACEUTICAL IND

Inventor： TSUJIKAWA KAZUTAKE ,  YAMAMOTO HIROSHI ,  UCHINO YUKIKO ,  KONISHI NOBORU

IPC: A61K38/00 ,  A61K39/395 ,  C07K14/72 ,  C07K16/40 ,  C12N1/20 ,  C12N5/20 ,  C12N9/12 ,  C12N15/12 ,  C12P21/08 ,  G01N33/573 ,  G01N33/574 ,  C07K16/30 ,  G01N33/53 ,  G01N33/577 ,  C12N15/62 ,  C12N15/63

Abstract: An antibody specific for LAR phosphatase subunit, in particular, the intracellular domain of LAR phosphatase subunit; a process for producing the same; cells producing the above antibody; a method for quantitating and examining LAR/LAR-derived molecules by using this antibody; and utilization of this antibody in diagnosing and treating thyroid cancer.

公开(公告)号：DE69936780T2

公开(公告)日：2008-06-05

申请号：DE69936780

申请日：1999-06-07

Applicant: FUSO PHARMACEUTICAL IND

Inventor： YAMAMOTO HIROSHI ,  TSUJIKAWA KAZUTAKE ,  UCHINO YUKIKO ,  KONISHI NOBORU

IPC: C12N15/12 ,  A61K38/00 ,  A61K39/395 ,  C07K14/72 ,  C07K16/40 ,  C12N1/20 ,  C12N5/20 ,  C12N9/12 ,  C12P21/08 ,  G01N33/573 ,  G01N33/574

Abstract: Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.

公开(公告)号：CA2332310C

公开(公告)日：2007-06-05

申请号：CA2332310

申请日：1999-07-06

Applicant: FUSO PHARMACEUTICAL IND

Inventor： TSUJIKAWA KAZUTAKE ,  YAMAMOTO HIROSHI ,  UCHINO YUKIKO

IPC: C07K16/40 ,  C07K1/22 ,  C07K16/18 ,  C12N5/20 ,  C12N9/16 ,  C12N15/06 ,  C12P21/08 ,  G01N33/53 ,  G01N33/573 ,  G01N33/577

Abstract: Antibodies to intracellular domains of two or more kinds of protein tyrosi ne phosphatases, methods for generation thereof and cells producing these antibodies are disclosed. The antibody of the present invention may have specificity to intracellular domains of phosphatase subunits of both of LAR and CD45, and may be useful f or analysis and quantitative determination of PTPs, identification and detection of nove l PTPs, and for obtaining novel phosphatases by cloning and the like, as well as for developing useful diagnostic methods of insulin resistance and NIDDM, for prophylaxis and diagnosis of various disease states of syndrome X that is based on insulin resistance, an d for prophylaxis and diagnosis of onsets of arteriosclerosis and cardiac diseases.

公开(公告)号：AU752642B2

公开(公告)日：2002-09-26

申请号：AU4060399

申请日：1999-06-07

Applicant: FUSO PHARMACEUTICAL IND

Inventor： YAMAMOTO HIROSHI ,  TSUJIKAWA KAZUTAKE ,  UCHINO YUKIKO ,  KONISHI NOBORU

IPC: A61K38/00 ,  A61K39/395 ,  C07K14/72 ,  C07K16/40 ,  C12N1/20 ,  C12N5/20 ,  C12N9/12 ,  C12N15/12 ,  C12P21/08 ,  G01N33/573 ,  G01N33/574 ,  C12N15/62 ,  C12N15/63 ,  C07K16/30 ,  G01N33/53 ,  G01N33/577

Abstract: Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.