公开(公告)号：WO0031277A9

公开(公告)日：2000-11-02

申请号：PCT/JP9906472

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND ,  UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N9/64 ,  C12N15/57 ,  A01K67/027 ,  C07K14/47 ,  C07K16/40 ,  C12N9/50 ,  C12P21/02 ,  G01N33/53

CPC classification number: C12N9/6424 ,  A01K2217/05 ,  A01K2217/075

Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 or proteins having amino acid sequences derived from the above sequences by deletion, substitution or addition of one or several amino acids therein; base sequences encoding the same; transgenic non-human animals having varied BSSP4 expression levels; an antibody against BSSP4; and a method for detecting BSSP4 in a specimen by using the antibody.

Abstract translation: 具有由SEQ ID NO：2,4,6,8,10,12,14,16,18和20代表的氨基酸序列的蛋白质或具有从上述序列衍生的氨基酸序列的蛋白质通过缺失，取代或添加一个 或其中的几种氨基酸; 编码相同的碱基序列; 具有不同BSSP4表达水平的转基因非人类动物; 抗BSSP4抗体; 以及使用该抗体检测标本中BSSP4的方法。

公开(公告)号：WO2005117993A3

公开(公告)日：2006-06-15

申请号：PCT/US2005019630

申请日：2005-06-03

Applicant: GENVEC INC ,  FUSO PHARMACEUTICAL IND ,  WICKHAM THOMAS J ,  AKIYAMA MASAKI ,  MURGESAN SELVA ,  EINFELD DAVID ,  ABE TOMOYUKI ,  YOSHIDA HIROSHI ,  YAMADA OSAMU ,  ARAKI HIROMASA

Inventor： WICKHAM THOMAS J ,  AKIYAMA MASAKI ,  MURGESAN SELVA ,  EINFELD DAVID ,  ABE TOMOYUKI ,  YOSHIDA HIROSHI ,  YAMADA OSAMU ,  ARAKI HIROMASA

IPC: A61K48/00 ,  C07K14/525 ,  C12N15/861

CPC classification number: C12N15/86 ,  A61K48/00 ,  A61K48/0075 ,  C07K14/525 ,  C12N7/00 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2810/405 ,  C12N2830/008

Abstract: The invention provides a method of destroying tumor cells in the peritoneal cavity of a mammal. The method comprises administering to the mammal intraperitoneally a dose of replication-deficient adenoviral vector comprising (a) an exogenous nucleic acid sequence encoding a human TNF-a which is operably linked to a tumor cell-selective promoter, (b) a fiber protein wherein a native CAR-binding site is disrupted, and (c) and a penton base protein wherein a native integrin-binding site is disrupted.

Abstract translation: 本发明提供一种破坏哺乳动物腹膜腔中的肿瘤细胞的方法。 该方法包括给予哺乳动物腹膜内一定剂量的复制缺陷型腺病毒载体，其包含（a）编码与肿瘤细胞选择性启动子有效连接的人TNF-α的外源核酸序列，（b）纤维蛋白，其中 天然CAR结合位点被破坏，和（c）和其中天然整联蛋白结合位点被破坏的五邻体蛋白质。

公开(公告)号：WO0031257A9

公开(公告)日：2001-04-05

申请号：PCT/JP9906476

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND ,  UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N1/21 ,  C12N9/64 ,  C12N15/12 ,  C12P21/08 ,  A01K67/027 ,  C07K16/40 ,  C12N5/06 ,  G01N33/543

CPC classification number: C12N9/6424

Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4 and 6 and proteins derived from these proteins by deletion, substitution or addition of one or several amino acids in these amino acid sequences; base sequences encoding these proteins; a transgenic non-human animal having an altered BSSP6 expression level; an antibody against BSSP6; and a method for detecting BSSP6 in a specimen by using this antibody.

Abstract translation: 具有由SEQ ID NO：2,4和6表示的氨基酸序列的蛋白质和通过在这些氨基酸序列中缺失，取代或添加一个或几个氨基酸而衍生自这些蛋白质的蛋白质; 编码这些蛋白质的碱基序列; 具有改变的BSSP6表达水平的转基因非人动物; 针对BSSP6的抗体; 以及通过使用该抗体检测标本中的BSSP6的方法。

公开(公告)号：EP2939602A4

公开(公告)日：2016-10-05

申请号：EP13867032

申请日：2013-11-21

Applicant: FUSO PHARMACEUTICAL IND ,  UNIV OSAKA

Inventor： NAKAJIMA KIYOKAZU ,  YAMAMOTO KEIICHI

IPC: A61B17/00 ,  A61B17/12 ,  A61M35/00

CPC classification number: A61B17/00491 ,  A61B17/132 ,  A61B2017/00544 ,  A61B2017/12004 ,  A61M35/00 ,  A61M39/22 ,  A61M2039/229

公开(公告)号：EP1870460A4

公开(公告)日：2008-12-24

申请号：EP06730889

申请日：2006-03-31

Applicant: FUSO PHARMACEUTICAL IND ,  OSAKA PREFECTURE

Inventor： KASE TETSUO ,  KIMURA AKIO ,  KISAKI HIROSHI ,  KESHI HIROYUKI ,  UEYAMA HIROSHI ,  NISHIHARA MIZUKI

IPC: C12N15/09 ,  C07K14/78 ,  C12N5/10 ,  C12P21/02

CPC classification number: C12P21/02 ,  C07K14/78

Abstract: Disclosed is a process for producing a human collagen molecule having substantially the same structure as that of a naturally occurring collagen molecule, which process can synthesize, in a host cell having a collagen gene introduced therein, a large amount of a human collagen protein derived from the gene introduced in a vector capable of expressing a foreign gene at a high level, and which process enables to isolate and purify the human collagen molecule in a simple manner. Also disclosed is a collagen molecule produced by the process. A collagen gene construct is introduced into a vector capable of expressing a foreign gene at a high level, and a cell capable of expressing a collagen molecule at a low level is selected from a variety of mammalian cells as a host, whereby human collagen with little contamination by host cell-derived collagen can be produced in a large amount.

公开(公告)号：EP1626090A4

公开(公告)日：2007-07-04

申请号：EP04711732

申请日：2004-02-17

Applicant: FUSO PHARMACEUTICAL IND ,  MAYUMI TADANORI ,  NAKAGAWA SHINSAKU ,  TSUTSUMI YASUO ,  KAWASAKI KOICHI ,  MAEDA MITSUKO

Inventor： MAYUMI TADANORI ,  NAKAGAWA SHINSAKU ,  TSUTSUMI YASUO ,  KAWASAKI KOICHI ,  MAEDA MITSUKO ,  HAYAKAWA TAKAO ,  MIZUGUCHI HIROYUKI

IPC: C12N15/861 ,  A61K48/00

CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2810/405

Abstract: It is intended to provide a virus vector characterized in that a water-soluble polymer is directly or indirectly bonded to the surface of a viral particle and a foreign peptide having an affinity for integrin occurring on the surface of a target cell is further bonded to the water-soluble polymer.

公开(公告)号：EP1231469A4

公开(公告)日：2004-12-01

申请号：EP00964707

申请日：2000-10-06

Applicant: FUSO PHARMACEUTICAL IND ,  MIWA KUNIO ,  SUGATANI JUNKO

Inventor： MIWA MASAO ,  SUGATANI JUNKO

IPC: G01N33/569 ,  G01N33/53 ,  G01N33/68

CPC classification number: G01N33/56916 ,  G01N2469/10

Abstract: A method of the early diagnosis of renal disorder, hemolytic-uremic syndrome and intestinal hemorrhagic Escherichia coli infection at the early stage; and a method of judging the severity of these diseases. The attack of renal disorder, hemolytic-uremic syndrome or intestinal hemorrhagic E. coli infection or the severity thereof is judged by detecting or quantitating AQP2 and/or molecules originating therein excreted into the urine of a subject. An immunochemical method with the use of an antibody specifically recognizing AQP2 is appropriately employed in the detection or quantification.

公开(公告)号：EP1283214A4

公开(公告)日：2004-09-22

申请号：EP01922014

申请日：2001-04-23

Applicant: FUSO PHARMACEUTICAL IND

Inventor： WAKAMIYA NOBUTAKA ,  KESHI HIROYUKI ,  OHTANI KATSUKI ,  SAKAMOTO TAKASHI ,  KISHI YUICHIRO

IPC: C07K14/47 ,  C07K14/785 ,  C12N15/12 ,  A01K67/027 ,  C07K16/18 ,  C12P21/02 ,  G01N33/53

CPC classification number: C07K14/4726 ,  A01K2217/05 ,  C07K14/785

Abstract: Isolated collectin (CL-L2s) genes containing a base sequence represented by SEQ ID NO:1, 3, 5, 7, 9, 12, 36, 38 or 40 relating to novel collectins which are expected as exhibiting an antibacterial activity, an antiviral activity, etc. particularly in the human body; and isolated collectin proteins containing an amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 13, 37, 39 or 41 and derivatives and fragments thereof.

公开(公告)号：EP1092772A4

公开(公告)日：2004-07-07

申请号：EP99923958

申请日：1999-06-07

Applicant: FUSO PHARMACEUTICAL IND

Inventor： YAMAMOTO HIROSHI ,  TSUJIKAWA KAZUTAKE ,  UCHINO YUKIKO ,  KONISHI NOBORU

IPC: A61K38/00 ,  A61K39/395 ,  C07K14/72 ,  C07K16/40 ,  C12N1/20 ,  C12N5/20 ,  C12N9/12 ,  C12N15/12 ,  C12P21/08 ,  G01N33/573 ,  G01N33/574

CPC classification number: C12N9/1205 ,  A61K38/00 ,  C07K14/72 ,  C07K16/40 ,  G01N33/573

Abstract: An antibody specific for LAR phosphatase subunit, in particular, the intracellular domain of LAR phosphatase subunit; a process for producing the same; cells producing the above antibody; a method for quantitating and examining LAR/LAR-derived molecules by using this antibody; and utilization of this antibody in diagnosing and treating thyroid cancer.

公开(公告)号：EP1132477A4

公开(公告)日：2003-05-07

申请号：EP99972687

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N9/64 ,  C12N15/57 ,  A01K67/027 ,  C07K14/47 ,  C07K16/40 ,  C12N9/50 ,  C12P21/02 ,  G01N33/53

CPC classification number: C12N9/6424 ,  A01K2217/05 ,  A01K2217/075

Abstract: Proteins having the amino acid sequences represented by SEQ ID NOS:2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 or proteins having amino acid sequences derived from the above sequences by deletion, substitution or addition of one or several amino acids therein; base sequences encoding the same; transgenic non-human animals having varied BSSP4 expression levels; an antibody against BSSP4; and a method for detecting BSSP4 in a specimen by using the antibody.