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    QUANTITATIVE PHASE MICROSCOPY FOR LABEL-FREE HIGH-CONTRAST CELL IMAGING
    1.
    发明申请
    QUANTITATIVE PHASE MICROSCOPY FOR LABEL-FREE HIGH-CONTRAST CELL IMAGING 审中-公开
    用于无标记高比例细胞成像的定量相显微镜

    公开(公告)号：WO2013095282A3

    公开(公告)日：2013-08-22

    申请号：PCT/SE2012051445

    申请日：2012-12-20

    Applicant: GEN ELECTRIC ,  GE HEALTHCARE BIO SCIENCES AB

    Inventor： FILKINS ROBERT ,  JOO CHULMAN ,  KIM EVGENIA MIKHAILOVNIA

    IPC: G02B21/14 ,  G02B21/00

    CPC classification number: G02B21/367 ,  G02B21/14

    Abstract: Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

    Abstract translation: 本文描述的系统和方法采用多个相位对比图像，其具有由样本衍射的光与样本不衍射的光之间的各种相对相移，以产生定量相位图像。 产生的定量相图像可以具有足够的对比度以用于细胞体和细胞核的无标记自动分割。

    6.
    发明专利
    未知

    公开(公告)号：DE60305077D1

    公开(公告)日：2006-06-08

    申请号：DE60305077

    申请日：2003-11-25

    Applicant: GEN ELECTRIC

    Inventor： KORNRUMPF P ,  CLAYDON GLENN ,  DASGUPTA SAMHITA ,  FILKINS ROBERT ,  FORMAN GLENN ,  IANNOTTI JOSEPH ,  NIELSEN CHRISTIAN

    IPC: G02F1/225 ,  G02F1/01 ,  G02F1/065

    Abstract: The invention comprises a novel combination of microwave and photonic packaging to arrive at compact, self contained MZI modulator. The nature of the NLO polymer, that is, its large electro-optic coefficient reduces the drive requirements for the integrated power amplifier, allowing a small to medium power amplifier to be used. Microwave high density interconnect (HDI) packaging techniques allow the medium power amplifier to be fabricated into a small assembly, which can be mounted directly to the MZI substrate. The integrated amplifier and modulator provides a significant reduced size and lower power, and high bandwidth advantage when compared with existing devices based on inorganic materials.

    СПОСОБ И УСТРОЙСТВО ДЛЯ ПЛАНИРОВАНИЯ СКАНИРОВАНИЯ С ИСПОЛЬЗОВАНИЕМ УЛЬТРАФИОЛЕТОВОГО ИЗЛУЧЕНИЯ
    7.
    发明专利
    СПОСОБ И УСТРОЙСТВО ДЛЯ ПЛАНИРОВАНИЯ СКАНИРОВАНИЯ С ИСПОЛЬЗОВАНИЕМ УЛЬТРАФИОЛЕТОВОГО ИЗЛУЧЕНИЯ 未知

    公开(公告)号：RU2540254C2

    公开(公告)日：2015-02-10

    申请号：RU2011146936

    申请日：2010-05-25

    Applicant: GEN ELECTRIC

    Inventor： FILKINS ROBERT ,  KENNY KEVIN B ,  ROYCE CHRISTINA C ,  TAIT ROBERT WILLIAM

    IPC: G02B21/36 ,  G01N21/64 ,  G06K9/32

    Abstract: Изобретениепредлагаетспособопределенияместоположенияодногоилиболееобразцовтканипосуществукруглойформы, размещенныхнатвердомносителе. Способвключаетэтапыподачисветас заданнойдлинойволнынаобразецткани, вкоторомэтотсветвызываетавтофлуоресценцию, идентификациюположенияцентраобразцатканинаосновеиспользованияавтофлуоресцентногосвета, корреляциюкоординатположенияцентраобразцатканинатвердомносителенаосновеиспользованиясистемыкоординатх, уи составлениекартыкоординатобразцатканинатвердомносителедляразличенияобластей, содержащихобразецткани, инезаполненныхобластейнатвердомносителе. Такжепредлагаетсяустройстводляопределенияместоположенияодногоилиболееобразцовтканипосуществукруглойформы, размещенныхнатвердомносителе. 2 н. и 20 з.п. ф-лы, 3 ил.

    Method and apparatus for ultraviolet scan planning
    8.
    发明专利
    Method and apparatus for ultraviolet scan planning 未知

    公开(公告)号：NZ596197A

    公开(公告)日：2014-01-31

    申请号：NZ59619710

    申请日：2010-05-25

    Applicant: GEN ELECTRIC

    Inventor： KENNY KEVIN B ,  TAIT ROBERT WILLIAM ,  FILKINS ROBERT ,  ROYCE CHRISTINA C

    IPC: G02B21/36 ,  G01N21/64 ,  G02B21/16 ,  G06K9/32 ,  G06T7/00

    Abstract: A method and an apparatus for locating one or more substantially circular-shaped tissue sample positioned on a solid support are disclosed. The method involves the steps of transmitting light of a preselected wavelength onto a tissue sample, wherein the light induces the tissue sample to autofluoresce, identifying the center location of the tissue sample using the autofluoresced light, correlating the coordinates of the center location of the tissue sample on the solid support using an x, y-coordinate system, and mapping the coordinates of the tissue sample on the solid support to differentiate tissue sample containing regions from blank regions on the solid support. In a second aspect, the invention provides an apparatus for locating one or more substantially circular-shaped tissue sample positioned on a solid support

    METHOD AND APPARATUS FOR ULTRAVIOLET SCAN PLANNING
    9.
    发明专利
    METHOD AND APPARATUS FOR ULTRAVIOLET SCAN PLANNING 未知

    公开(公告)号：HK1170572A1

    公开(公告)日：2013-03-01

    申请号：HK12111064

    申请日：2012-11-02

    Applicant: GEN ELECTRIC

    Inventor： FILKINS ROBERT ,  KENNY KEVIN B ,  ROYCE CHRISTINA C ,  TAIT ROBERT WILLIAM

    IPC: G02B20060101 ,  G01N20060101 ,  G06K20060101 ,  G06T20060101

    Abstract: The invention provides method for locating one or more substantially circular-shaped tissue sample positioned on a solid support. The method involves the steps of transmitting light of a preselected wavelength onto a tissue sample, wherein the light induces the tissue sample to autofluoresce, identifying the center location of the tissue sample using the autofluoresced light, correlating the coordinates of the center location of the tissue sample on the solid support using an x, y-coordinate system, and mapping the coordinates of the tissue sample on the solid support to differentiate tissue sample containing regions from blank regions on the solid support. In a second aspect, the invention provides an apparatus for locating one or more substantially circular-shaped tissue sample positioned on a solid support.

    Análisis secuencial de muestras biológicas
    10.
    发明专利
    Análisis secuencial de muestras biológicas 未知

    公开(公告)号：ES2459725T3

    公开(公告)日：2014-05-12

    申请号：ES11175116

    申请日：2007-11-15

    Applicant: GEN ELECTRIC

    Inventor： PANG ZHENGYU ,  FILKINS ROBERT ,  MONTALTO MICHAEL ,  GINTY FIONA ,  GERDES MICHAEL ,  CAN ALI ,  BRESNAHAN MAUREEN ,  SOOD ANUP

    IPC: G01N33/542

    Abstract: Un método para sondear dianas múltiples en una muestra biológica que comprende una sección de tejido, método que comprende: (a) proporcionar una sección de tejido que contiene múltiples dianas; (b) unir al menos una sonda de anticuerpo marcada con fluoróforo a una o más dianas presentes en la sección de tejido; (c) unir al menos una sonda de control a una o más dianas presentes en la sección de tejido; (d) detectar al menos una señal procedente de al menos una sonda de anticuerpo marcada con fluoróforo unida en la etapa (b) y detectar al menos una señal de control procedente de al menos una sonda de control unida en la etapa (c); (e) aplicar a la muestra de la etapa (d) una disolución que comprende un agente oxidante que desactiva selectivamente la(s) marca(s) de fluoróforo(s) de al menos una sonda de anticuerpo marcada con fluoróforo y no la(s) sonda(s) de control; (f) unir al menos una sonda de anticuerpo marcada con fluoróforo a una o más dianas presentes en la muestra tras la etapa (e); y (g) detectar al menos una señal procedente de al menos una sonda de anticuerpo marcada con fluoróforo unida en la etapa (f).

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