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    METHOD FOR THE SEQUENTIAL ANALYSIS OF DIFFERENT COMPONENTS IN A SINGLE BIOLOGICAL SAMPLE AND REAGENTS THEREFOR
    1.
    发明申请
    METHOD FOR THE SEQUENTIAL ANALYSIS OF DIFFERENT COMPONENTS IN A SINGLE BIOLOGICAL SAMPLE AND REAGENTS THEREFOR 审中-公开
    单一生物样品和试剂中不同成分的顺序分析方法

    公开(公告)号：WO2008064067A3

    公开(公告)日：2008-07-10

    申请号：PCT/US2007084800

    申请日：2007-11-15

    Applicant: GEN ELECTRIC ,  PANG ZHENGYU ,  FILKINS ROBERT JOHN ,  MONTALTO MICHAEL CHRISTOPHER ,  GINTY FIONA ,  GERDES MICHAEL J ,  CAN ALI ,  BRESNAHAN MAUREEN ANN ,  SOOD ANUP

    Inventor： PANG ZHENGYU ,  FILKINS ROBERT JOHN ,  MONTALTO MICHAEL CHRISTOPHER ,  GINTY FIONA ,  GERDES MICHAEL J ,  CAN ALI ,  BRESNAHAN MAUREEN ANN ,  SOOD ANUP

    IPC: G01N33/50 ,  C12Q1/68

    CPC classification number: G01N33/582 ,  C12Q1/6816 ,  G01N33/542 ,  C12Q2545/101 ,  C12Q2527/125

    Abstract: Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one fluorescent probe to one or more target present in the sample, and binding at least at least one control probe to one or more target present in the sample. The methods include the steps of observing a signal from the fluorescent probe and a control signal from the control probe and applying to the sample a basic solution containing an oxidizing agent that selectively inactivates the fluorescent probe and not the control probe. The methods further include the steps of binding at least one fluorescent probe to one or more target present in the sample and observing a signal from the fluorescent probe. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided.

    Abstract translation: 提供了探索生物样品中多个靶标的方法。 所述方法包括以下步骤：提供含有多个靶标的生物样品，将至少一种荧光探针结合至样品中存在的一种或多种靶标，以及将至少一种对照探针结合至样品中存在的一种或多种靶标。 所述方法包括以下步骤：观察来自荧光探针的信号和来自对照探针的控制信号，并向样品施加含有选择性地使荧光探针失活而不是对照探针的氧化剂的碱性溶液。 所述方法还包括将至少一种荧光探针结合到样品中存在的一种或多种目标物并观察来自荧光探针的信号的步骤。 本文公开的方法还提供结合，观察和氧化的多次迭代，用于导出关于单个样品中的多个靶的信息。 还提供了相关的套件。

    SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES WITH BLEACHING OF INTERMEDIATE FLUORESCENT SIGNALS
    3.
    发明申请
    SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES WITH BLEACHING OF INTERMEDIATE FLUORESCENT SIGNALS 审中-公开
    中间荧光信号漂白生物样品的顺序分析

    公开(公告)号：WO2008133727A3

    公开(公告)日：2009-01-22

    申请号：PCT/US2007084783

    申请日：2007-11-15

    Applicant: GEN ELECTRIC ,  FILKINS ROBERT JOHN ,  MONTALTO MICHAEL CHRISTOPHER ,  SOOD ANUP ,  GERDES MICHAEL J ,  SEEL MAXIMILIAN LEWIS

    Inventor： FILKINS ROBERT JOHN ,  MONTALTO MICHAEL CHRISTOPHER ,  SOOD ANUP ,  GERDES MICHAEL J ,  SEEL MAXIMILIAN LEWIS

    IPC: G01N33/542

    CPC classification number: G01N33/53 ,  C12Q1/68 ,  G01N33/542 ,  G01N33/582 ,  Y10T436/143333

    Abstract: Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.

    Abstract translation: 提供了用于检测生物样品中多个靶的方法。 所述方法包括使样品与第一探针接触; 将第一探针物理地绑定到第一靶; 观察来自第一探针的第一信号; 施用化学试剂来修饰第一信号; 使样品与第二探针接触; 将第二探针物理地绑定到第二靶上; 并观察来自第二探测器的第二信号。 本文公开的方法还提供绑定，观察，信号修改的多次迭代，用于导出关于单个样本中的多个目标的信息。 还提供了相关的套件和设备。

    EDDY CURRENT PROBE
    5.
    发明专利
    EDDY CURRENT PROBE 失效

    公开(公告)号：JPH10307126A

    公开(公告)日：1998-11-17

    申请号：JP3650998

    申请日：1998-02-19

    Applicant: GEN ELECTRIC

    Inventor： PATTON THADD CLARK ,  FILKINS ROBERT JOHN ,  FULTON JAMES PAUL ,  HEDENGREN KRISTINA HELENA VAL ,  YOUNG JOHN DAVID

    IPC: G01N27/90

    Abstract: PROBLEM TO BE SOLVED: To reduce costs and to enable a probe to be held by hands by mounting an eddy current detection coil to a substrate so that it can be rotated freely, rotating it around the ordinate line of a first elastic member, and allowing an eddy current probe to have a means for measuring the rotary angle of the axial line in the longitudinal direction of the eddy current detection coil around the ordinate line for a reference direction being fixed to the substrate. SOLUTION: An eddy current detection coil 20 is mounted to a substrate 22 so that it can be rotated freely and can rotate around an ordinate line 28. Also, an eddy current probe 10 has a means for measuring the rotary angle of the ordinate line in the longer direction of the eddy current detection coil 20 around the ordinate line 28 for the reference direction being fixed to the substrate 22. Further, the eddy current probe 10 is mounted to a second surface 26 of the substrate 22 and includes a signal amplifier 64 that is electrically connected to the eddy current detection coil 20, thus improving an S/N ratio and hence improving the detection of a flaw.

    METHOD FOR THE SEQUENTIAL ANALYSIS OF DIFFERENT COMPONENTS IN A SINGLE BIOLOGICAL SAMPLE AND REAGENTS THEREFOR
    6.
    发明专利
    METHOD FOR THE SEQUENTIAL ANALYSIS OF DIFFERENT COMPONENTS IN A SINGLE BIOLOGICAL SAMPLE AND REAGENTS THEREFOR 未知

    公开(公告)号：CA2669092C

    公开(公告)日：2016-07-26

    申请号：CA2669092

    申请日：2007-11-15

    Applicant: GEN ELECTRIC

    Inventor： PANG ZHENGYU ,  FILKINS ROBERT JOHN ,  MONTALTO MICHAEL CHRISTOPHER ,  GINTY FIONA ,  GERDES MICHAEL J ,  CAN ALI ,  BRESNAHAN MAUREEN ANN ,  SOOD ANUP

    IPC: G01N33/50 ,  C12Q1/68

    Abstract: Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one fluorescent probe to one or more target present in the sample, and binding at least at least one control probe to one or more target present in the sample. The methods include the steps of observing a signal from the fluorescent probe and a control signal from the control probe and applying to the sample a basic solution containing an oxidizing agent that selectively inactivates the fluorescent probe and not the control probe. The methods further include the steps of binding at least one fluorescent probe to one or more target present in the sample and observing a signal from the fluorescent probe. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided.

    8.
    发明专利
    未知

    公开(公告)号：DE69838011D1

    公开(公告)日：2007-08-16

    申请号：DE69838011

    申请日：1998-02-11

    Applicant: GEN ELECTRIC

    Inventor： PATTON THADD CLARK ,  FILKINS ROBERT JOHN ,  FULTON JAMES PAUL ,  HEDENGREN KRISTINA HELENA VAL ,  YOUNG JOHN DAVID

    IPC: G01N27/90

    Abstract: An eddy current probe (10) is provided which can be moved by hand to a surface to be tested. A toroidal-shaped first resilient member (14) contacts the bottom face of a support member (12). An elastic membrane (16) extends over the bore (33) of the first resilient member (14), contacts the bottom lateral surface of the first resilient member (14), and is unattached to the radially inward-facing surface of the first resilient member (14). A more elastic, second resilient member (18) is placed in the bore (33), is unattached to the first resilient member (14), and contacts the bottom surface of the elastic membrane (16). A flexible, surface-conformable, eddy current sensing (20) coil overlies a portion of the bottom side of the second resilient member (18).

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