公开(公告)号：WO2008136734A1

公开(公告)日：2008-11-13

申请号：PCT/SE2008/000308

申请日：2008-05-05

Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE BIO-SCIENCES AB ,  BARASH, Eugene ,  DOVIDENKO, Katharine ,  LORRAINE, Peter, W. ,  POTYRAILO, Radislav, Alexandrovich

Inventor： BARASH, Eugene ,  DOVIDENKO, Katharine ,  LORRAINE, Peter, W. ,  POTYRAILO, Radislav, Alexandrovich

IPC: G01N21/55 ,  G01N33/543

CPC classification number: G01N21/554 ,  G01N21/648 ,  G01N33/54373 ,  G01N33/553 ,  G01N2021/6439

Abstract: Methods and systems for detecting biological or biochemical analytes generally comprising, a metal film having one or more surfaces comprising one or more submicron structures; a device for applying one or more analytes to at least a portion of the film surface to interact with said metal film; a light source for illuminating a surface of the metal film so that at least some of the light is adapted to be optically altered by the functionalized metal film; and an optical detection subsystem for collecting the optically altered light, wherein the altered light is indicative of surface plasmon resonance on the film, and detecting one or more properties of the analytes based on the collected light.

Abstract translation: 用于检测生物或生化分析物的方法和系统通常包括具有一个或多个包含一个或多个亚微米结构的表面的金属膜; 用于将一种或多种分析物施加到所述膜表面的至少一部分以与所述金属膜相互作用的装置; 用于照射金属膜的表面的光源，使得至少一些光适于被官能化金属膜光学改变; 以及用于收集光学改变的光的光学检测子系统，其中改变的光指示膜上的表面等离子体共振，以及基于所收集的光检测分析物的一种或多种性质。

公开(公告)号：WO2007103642A2

公开(公告)日：2007-09-13

申请号：PCT/US2007/062667

申请日：2007-02-23

Applicant: GENERAL ELECTRIC COMPANY ,  FOMITCHOV, Pavel A. ,  BARASH, Eugene ,  YEKTA, Ahmad ,  MASINO, Joseph

Inventor： FOMITCHOV, Pavel A. ,  BARASH, Eugene ,  YEKTA, Ahmad ,  MASINO, Joseph

IPC: G01N21/25

CPC classification number: G01N21/6458 ,  G01N21/47 ,  G01N2201/0407 ,  G01N2201/1042 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/367

Abstract: A system and method for multimode imaging of at least one sample is disclosed. The system includes at least one light source; an optical system selected responsive to a mode of operation of the imaging system; and a detector capable of selective reading of pixels. The at least one sample is moved relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving. The method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through an optical system selected in response to the mode of operation for the imaging system; (3) moving the at least one sample relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving; and (4) selectively reading pixels with a detector.

Abstract translation: 公开了一种用于至少一个样品的多模成像的系统和方法。 该系统包括至少一个光源; 响应于成像系统的操作模式选择的光学系统; 以及能够选择性地读取像素的检测器。 使用选自步骤样品移动和连续样品移动的样品移动技术，使至少一个样品相对于光学系统移动。 该方法包括以下步骤：（1）选择成像系统的操作模式; （2）从至少一个光源透射通过响应于成像系统的操作模式选择的光学系统的光; （3）使用选自步骤样品移动和连续样品移动的样本移动技术来移动所述至少一个样品相对于所述光学系统; 和（4）用检测器选择性地读取像素。

公开(公告)号：WO2009073306A1

公开(公告)日：2009-06-11

申请号：PCT/US2008/082539

申请日：2008-11-06

Applicant: GENERAL ELECTRIC COMPANY ,  BARASH, Eugene ,  PRIS, Andrew David

Inventor： BARASH, Eugene ,  PRIS, Andrew David

IPC: G01N21/64 ,  C12M1/34

CPC classification number: G01N21/645 ,  G01N21/0332 ,  G01N21/55 ,  G01N2021/575 ,  G01N2021/6471

Abstract: A device and method for detecting the presence of one or more analytes, bound directly or indirectly to a binding substrate functionalized with a fluorophore, based on measurements of fluorescence and reflectivity. The device and methods comprise an excitation source that emits light capable of being absorbed by a fluorophore and results in the fluorophore's excitation and emission, a fluorescent probe specific for the analyte that is attached via chemisorption to the binding substrate, a detector, and a processor adapted to determine the quantity of the one or more analytes present, by correlating measurements of reflected and fluorescent light.

Abstract translation: 基于荧光和反射率的测量来检测直接或间接结合到用荧光团官能化的结合底物的一种或多种分析物的存在的装置和方法。 该装置和方法包括发射能够被荧光团吸收并导致荧光团的激发和发射的光的激发源，对通过化学吸附附着到结合基底的分析物特异的荧光探针，检测器和处理器 适于通过将反射和荧光的测量相关联来确定存在的一种或多种分析物的量。

公开(公告)号：WO2010016795A1

公开(公告)日：2010-02-11

申请号：PCT/SE2009/050918

申请日：2009-08-04

Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE BIO-SCIENCES AB ,  BARASH, Eugene ,  FINEHOUT, Erin ,  PIETRZYKOWSKI, Matthew, Damian ,  XIA, Hua ,  ZHU, Li

Inventor： BARASH, Eugene ,  FINEHOUT, Erin ,  PIETRZYKOWSKI, Matthew, Damian ,  XIA, Hua ,  ZHU, Li

IPC: G01N27/447 ,  G01N21/64 ,  G01N33/487

CPC classification number: G01N21/645 ,  B01L3/5027 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/08 ,  G01J3/4406 ,  G01N21/6408 ,  G01N2021/6419 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fluorescence detection system comprises a light source configured to produce an excitation light, an optical lens and a fiber bundle. The optical lens is configured to focus the excitation light to a sample to emit fluorescence and to collect the fluorescence. The fiber bundle probe comprises a transmitting fiber configured to transmit the excitation light to the optical lens, and a first receiving fiber configured to deliver the collected fluorescence. The fluorescence detection system further comprises a first detector configured to detect the fluorescence delivered by the receiving fiber to generate a response signal, and a processing unit configured to determine information about the samples by analyzing the response signal. Additionally, a fluorescence detection method is also presented.

Abstract translation: 荧光检测系统包括被配置为产生激发光，光学透镜和光纤束的光源。 光学透镜被配置为将激发光聚焦到样品以发射荧光并收集荧光。 纤维束探针包括被配置为将激发光透射到光学透镜的发射光纤和被配置为传送所收集的荧光的第一接收光纤。 荧光检测系统还包括第一检测器，其被配置为检测由接收光纤传送的荧光以产生响应信号;以及处理单元，被配置为通过分析响应信号来确定关于样本的信息。 另外，还提出了荧光检测方法。

公开(公告)号：EP1991860A2

公开(公告)日：2008-11-19

申请号：EP07717653.5

申请日：2007-02-23

Applicant: GENERAL ELECTRIC COMPANY

Inventor： FOMITCHOV, Pavel A. ,  BARASH, Eugene ,  YEKTA, Ahmad ,  MASINO, Joseph

IPC: G01N23/00

CPC classification number: G01N21/6458 ,  G01N21/47 ,  G01N2201/0407 ,  G01N2201/1042 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/367

Abstract: A system and method for multimode imaging of at least one sample is disclosed. The system includes at least one light source; an optical system selected responsive to a mode of operation of the imaging system; and a detector capable of selective reading of pixels. The at least one sample is moved relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving. The method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through an optical system selected in response to the mode of operation for the imaging system; (3) moving the at least one sample relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving; and (4) selectively reading pixels with a detector.

公开(公告)号：EP2212678A1

公开(公告)日：2010-08-04

申请号：EP08856342.4

申请日：2008-11-06

Applicant: General Electric Company

Inventor： BARASH, Eugene ,  PRIS, Andrew David

IPC: G01N21/64 ,  C12M1/34

CPC classification number: G01N21/645 ,  G01N21/0332 ,  G01N21/55 ,  G01N2021/575 ,  G01N2021/6471

Abstract: A device and method for detecting the presence of one or more analytes, bound directly or indirectly to a binding substrate functionalized with a fluorophore, based on measurements of fluorescence and reflectivity. The device and methods comprise an excitation source that emits light capable of being absorbed by a fluorophore and results in the fluorophore's excitation and emission, a fluorescent probe specific for the analyte that is attached via chemisorption to the binding substrate, a detector, and a processor adapted to determine the quantity of the one or more analytes present, by correlating measurements of reflected and fluorescent light.