公开(公告)号：WO2013003530A1

公开(公告)日：2013-01-03

申请号：PCT/US2012/044527

申请日：2012-06-28

Applicant: GENERAL ELECTRIC COMPANY ,  RENSCH, Christian ,  BALLER, Marko ,  BOELD, Christoph ,  HORVATH-KLEIN, Ruben Julian ,  SAMPER, Victor ,  ULIN, Johan

Inventor： RENSCH, Christian ,  BALLER, Marko ,  BOELD, Christoph ,  HORVATH-KLEIN, Ruben Julian ,  SAMPER, Victor ,  ULIN, Johan

IPC: C07B59/00 ,  B01J19/00

CPC classification number: C07B59/00 ,  G21F9/06 ,  G21F9/12

Abstract: Disclosed are devices and methods for reducing radiolysis of radiopharmaceuticals during filtration, concentration and purification. The devices comprises two or more confining geometry having a cross-section dimension below the beta(+) or beta(-) range of the radioisotope in use, when containing the radioisotope, and configured in such a way that neighboring geometries are isolated from its nearest neighbor such that no measurable kinetic positron energy transfer occurs between the confining geometries when containing the radioisotope. Methods of filtration of radioisotope containing mixtures are also disclosed.

Abstract translation: 公开了用于在过滤，浓缩和纯化期间减少放射性药物的放射分解的装置和方法。 这些装置包括两个或更多个约束几何形状，其在使用时具有低于放射性同位素的β（+）或β（ - ）范围的横截面尺寸，当包含放射性同位素时，并且以这样一种方式构造相邻几何形状 最近邻居，使得当包含放射性同位素时，在约束几何之间不发生可测量的动能正电子能量转移。 还公开了含有放射性同位素的混合物的过滤方法。

公开(公告)号：WO1994021653A1

公开(公告)日：1994-09-29

申请号：PCT/US1994002366

申请日：1994-03-04

Applicant: GENERAL ELECTRIC COMPANY

Inventor： GENERAL ELECTRIC COMPANY ,  JOHNSON, Bruce, Fletcher ,  KISELEV, Maxim, Yurievich ,  ULIN, Johan

IPC: C07H01/00

CPC classification number: C07H5/02

Abstract: A method is provided for preparing [ F]2-fluoro-2-deoxyglucose with an anion exchange resin by effecting an exchange reaction between an aqueous solution of [ F]fluoride containing an alkali metal carbonate or bicarbonate, such as sodium bicarbonate, and an anion, such as bicarbonate or carbonate, on the anion exchange resin followed by the displacement reaction with 1,3,4,6-tetra-O-acetyl-2-0-trifluoromethanesulfonyl- beta -D-mannopyranose to form the resulting 2-fluoro-2-deoxyglucose tetraacetate. Improved yields of the [ F]2-fluoro-2-deoxyglucose are obtained when the alkali bicarbonate or carbonate is used in the target water.

Abstract translation: 提供了通过在含有碱金属碳酸盐或碳酸氢盐的[18 F]氟化氢水溶液之间进行交换反应，用阴离子交换树脂制备[18 F] 2-氟-2-脱氧葡萄糖的方法， 作为碳酸氢钠，和阴离子如碳酸氢盐或碳酸盐，在阴离子交换树脂上，然后与1,3,4,6-四-O-乙酰基-2-0-三氟甲磺酰基-β-D-吡喃甘露糖反应 以形成所得的2-氟-2-脱氧葡萄糖四乙酸酯。 当目标水中使用碱金属碳酸氢盐或碳酸盐时，可获得[18 F] 2-氟-2-脱氧葡萄糖的产率提高。

公开(公告)号：EP2726443A1

公开(公告)日：2014-05-07

申请号：EP12738666.2

申请日：2012-06-28

Applicant: General Electric Company

Inventor： RENSCH, Christian ,  BALLER, Marko ,  BOELD, Christoph ,  HORVATH-KLEIN, Ruben Julian ,  SAMPER, Victor ,  ULIN, Johan

IPC: C07B59/00 ,  B01J19/00

CPC classification number: C07B59/00 ,  G21F9/06 ,  G21F9/12

Abstract: Disclosed are devices and methods for reducing radiolysis of radiopharmaceuticals during filtration, concentration and purification. The devices comprises two or more confining geometry having a cross-section dimension below the beta(+) or beta(-) range of the radioisotope in use, when containing the radioisotope, and configured in such a way that neighboring geometries are isolated from its nearest neighbor such that no measurable kinetic positron energy transfer occurs between the confining geometries when containing the radioisotope. Methods of filtration of radioisotope containing mixtures are also disclosed.

公开(公告)号：EP0641350A1

公开(公告)日：1995-03-08

申请号：EP94909856.0

申请日：1994-03-04

Applicant: GENERAL ELECTRIC COMPANY

Inventor： JOHNSON, Bruce, Fletcher ,  KISELEV, Maxim, Yurievich ,  ULIN, Johan

IPC: C07H5

CPC classification number: C07H5/02

Abstract: A method is provided for preparing [18F]2-fluoro-2-deoxyglucose with an anion exchange resin by effecting an exchange reaction between an aqueous solution of [18F]fluoride containing an alkali metal carbonate or bicarbonate, such as sodium bicarbonate, and an anion, such as bicarbonate or carbonate, on the anion exchange resin followed by the displacement reaction with 1,3,4,6-tetra-O-acetyl-2-0-trifluoromethanesulfonyl-β-D-mannopyranose to form the resulting 2-fluoro-2-deoxyglucose tetraacetate. Improved yields of the [18F]2-fluoro-2-deoxyglucose are obtained when the alkali bicarbonate or carbonate is used in the target water.

Abstract translation: 本发明提供了一种用阴离子交换树脂制备[18 F] 2-氟-2-脱氧葡萄糖的方法，该方法是通过在含有碱金属碳酸盐或碳酸氢盐如碳酸氢钠的[18 F]氟化物水溶液与碳酸氢钠 阴离子例如碳酸氢盐或碳酸盐，然后与1,3,4,6-四-O-乙酰基-2-O-三氟甲磺酰基-β-D-吡喃甘露糖进行置换反应，形成所得2- 2-氟-2-脱氧葡萄糖四乙酸酯。 当在目标水中使用碱金属碳酸氢盐或碳酸盐时，获得[18 F] 2-氟-2-脱氧葡萄糖的产率提高。