中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

12 records (took 0.021 seconds)

    Cck or gastrin modulating 1,5 benzodiazepines derivatives
    1.
    发明专利
    Cck or gastrin modulating 1,5 benzodiazepines derivatives 未知

    公开(公告)号：AU2306295A

    公开(公告)日：1995-11-10

    申请号：AU2306295

    申请日：1995-04-13

    Applicant: GLAXO INC

    Inventor： AQUINO CHRISTOPHER JOSEPH ,  DEZUBE MILANA ,  HENKE BRAD RICHARD ,  BRACKEEN MARCUS ,  JEFFS PETER WALTER ,  SUH EDWARD MARTIN ,  HIRST GAVIN CHARLES ,  SUGG ELIZABETH ELLEN ,  WILLSON TIMOTHY MARK ,  MOMTAHEN TANYA

    IPC: A61K31/55 ,  A61P1/00 ,  A61P1/16 ,  A61P3/04 ,  C07D243/12 ,  C07D401/04 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D498/04

    Abstract: PCT No. PCT/EP95/01336 Sec. 371 Date Nov. 14, 1996 Sec. 102(e) Date Nov. 14, 1996 PCT Filed Apr. 13, 1995 PCT Pub. No. WO95/28391 PCT Pub. Date Oct. 26, 1995 (I) Benzo[b][1,4]diazepine compounds of formula (I), where R1 is selected from C1C6alkyl, C3-C6cycloalkyl, phenyl, or substituted phenyl; R2 is selected from C3-C6alkyl, C3C6cycloalkyl, C3-C6alkenyl, benzyl, phenylC1-C3alkyl of substituted phenyl; or NR1R2 together form 1,2,3,4-tetrahydroquinoline or benzazepine, mono-, di-, or trisubstituted independently with C1-6alkyl C1-6alkoxy or halogen substituents; p is an integer 0 or 1; q is an integer 0 or 1; r is an integer 0 or 1; t is an integer 0 or 1, provided that when r is 0 then t is 0; R3, R5, and R6 are independently hydrogen or C1-6alkyl; R4 is C1-6alkyl or C1-6alkenyl; R7 is selected from the group consisting of hydrogen, C1-6alkyl, C1-6cycloalkyl, C1-6alkenyl, phenyl, substituted phenyl, napthyl, heteroaryl, substituted heteroaryl, bicycloheteroaryl or substituted bicycloheteroaryl; or NR6R7 together form a saturated 5,6, or 7 membered ring optionally interrupted by 1,2,3 or 4 N, S or O heteroatoms, with the proviso that any two O or S atoms are not bonded to each other, m is an integer selected from the group of 0, 1, 2, 3 or 4; R8 and R9 are selected from a variety of substituents; Z is hydrogen or halogen; novel intermediates, a pharmaceutical composition for treating obesity, gall bladder stasis, disorders of pancreatic secretion, methods for such treatment and processes for preparing compounds of formula (I).

    1,5 benzodiazepine derivatives
    10.
    发明专利
    1,5 benzodiazepine derivatives 未知

    公开(公告)号：ZA942570B

    公开(公告)日：1994-11-11

    申请号：ZA942570

    申请日：1994-04-14

    Applicant: GLAXO INC

    Inventor： SUGG ELIZABETH ELLEN ,  AQUINO CHRISTOPHER JOSEPH ,  SZEWCZYK JERZY RYSZARD ,  FINCH HARRY ,  CARR ROBIN ARTHUR ELLIS

    IPC: A61K31/551 ,  A61K38/02 ,  A61K38/00 ,  A61P3/00 ,  A61P5/00 ,  A61P43/00 ,  C07D243/12 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/097 ,  C07K ,  A61K

    Abstract: PCT No. PCT/EP94/01130 Sec. 371 Date Oct. 30, 1995 Sec. 102(e) Date Oct. 30, 1995 PCT Filed Apr. 13, 1994 PCT Pub. No. WO94/24151 PCT Pub. Date Oct. 27, 1994The present invention relates to compounds of general formula (I) (I) and physiologically acceptable salts thereof wherein the group NR1R2 represents a 5-7 membered saturated heterocyclic ring which may be substituted by one or two methyl groups; R3 is C1-6alkyl, C3-6cycloalkyl or phenyl optionally substituted by 1 or 2 halogen atoms; R4 is phenyl or phenyl substituted by one or two groups selected from the group consisting of halogen, C1-4alkyl, trifluoromethyl, trifluoromethoxy or (CH2)nR5 wherein n is zero or 1 and R5 represents C1-4alkoxy, hydroxy, nitro, cyano, CO2R6, S(O)pCH3, NR7R8, CONR7R8, SO2NR7CO(C1-4)alkyl, tetrazolyl, carboxamidotetrazolyl, or a 3-trifluoromethyl 1,2,4-triazolyl; R6 is hydrogen, C1-4alkyl or benzyl; R7 is hydrogen or C1-4alkyl, R8 is hydrogen, C1-4alkyl, SO2CH3 or SO2CF3, X represent hydrogen, C1-4alkyl or halogen; m is zero, 1 or 2, and p is zero, 1 or 2. The invention also relates to processes for preparation of these compounds and to their use in medicine as antagonists of gastrin and CCK.

Patent Agency Ranking