公开(公告)号：ZA953111B

公开(公告)日：1996-01-23

申请号：ZA953111

申请日：1995-04-18

Applicant: GLAXO INC

Inventor： AQUINO CHRISTOPHER JOSEPH ,  DEZUBE MILANA ,  SUGG ELIZABETH ELLEN ,  SHERRILL RONALD GEORGE ,  WILLSON TIMOTHY MARK ,  SZEWCZYK JERZY RYSZARD

IPC: A61K20060101 ,  C07D20060101 ,  C07D ,  A61K

公开(公告)号：AU2446295A

公开(公告)日：1995-11-10

申请号：AU2446295

申请日：1995-04-13

Applicant: GLAXO INC

Inventor： AQUINO CHRISTOPHER JOSEPH ,  DEZUBE MILANA ,  SUGG ELIZABETH ELLEN ,  SHERRILL RONALD GEORGE ,  WILLSON TIMOTHY MARK ,  SZEWCZYK JERZY RYSZARD

IPC: C07D243/14 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61P1/00 ,  A61P1/16 ,  A61P3/04 ,  A61P25/00 ,  A61P43/00 ,  C07D243/24 ,  C07D401/04 ,  C07D403/06 ,  C07D403/12 ,  C07D487/04

Abstract: PCT No. PCT/EP95/01335 Sec. 371 Date Oct. 11, 1996 Sec. 102(e) Date Oct. 11, 1996 PCT Filed Apr. 13, 1995 PCT Pub. No. WO95/28399 PCT Pub. Date Oct. 26, 1995A method of inducing a Cholescystokinin-A receptor agonist response in a mammal by administering a compound of formula (I), (I) where R1 is C1-C6alkyl, C3-6cycloalkyl, phenyl, or substituted phenyl; R2 is C3-6alkyl, C3-6cycloalkyl, C3-6alkenyl, benzyl, phenylC1-3alkyl or substituted phenyl; or NR1R2 together form 1,2,3,4-tetrahydroquinoline or benzazepine mono-, di-, or trisubstituted independently with C1-6alkyl, C1-6alkoxy or halogen substituents; n is an integer selected from the grouping consisting of 0,1,2 or 3; p is the integer 0 or 1; q is the integer 0 or 1; r is the integer 0 or 1, provided that when q is 0 then r is 0; R3, R4, R5 and R8 are selected from a variety of substituents; X is nitrogen, nitroso or R8; m is an integer selected from the group consisting of 0, 1, 2 or 3; Y and Z are hydrogen or halogen, novel intermediates, a pharmaceutical composition for treating obesity, gall bladder stasis, disorders of pancreatic secretion, methods for such treatment and processes for preparing compounds of formula (I).

公开(公告)号：ZA9503111B

公开(公告)日：1996-01-23

申请号：ZA9503111

申请日：1995-04-18

Applicant: GLAXO INC

Inventor： AQUINO CHRISTOPHER JOSEPH ,  DEZUBE MILANA ,  SUGG ELIZABETH ELLEN ,  SHERRILL RONALD GEORGE ,  WILLSON TIMOTHY MARK ,  SZEWCZYK JERZY RYSZARD

IPC: A61K20060101 ,  C07D20060101 ,  C07D ,  A61K