公开(公告)号：US20150377865A1

公开(公告)日：2015-12-31

申请号：US14318220

申请日：2014-06-27

Applicant: Google Inc.

Inventor： Victor Marcel Acosta ,  Vikram Singh Bajaj ,  Jason Donald Thompson ,  Eric Peeters

IPC: G01N33/50 ,  A61B5/1455

CPC classification number: A61K49/005 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/1455 ,  A61B2576/00 ,  A61K49/0002 ,  A61K49/001 ,  A61M5/007 ,  G01N33/5091 ,  G01N33/54333 ,  G01N33/54346 ,  G01N33/544 ,  G01N33/551

Abstract: An imaging agent for detecting analytes in an environment includes functionalized nanodiamonds and functionalized magnetic particles that can selectively interact with an analyte. Each functionalized nanodiamond contains at least one color center configured emit light in response to illumination. At least one property of the light emitted by the color centers is related to the proximity of the functionalized magnetic particles to the color centers. This property can be detected to determine that the functionalized nanodiamonds are proximate to the functionalized magnetic particles, to determine that the functionalized nanodiamonds and the functionalized magnetic particles are interacting with the analyte, or other applications. Devices and methods for detecting properties of the analyte by interacting with the functionalized nanodiamonds and functionalized magnetic particles are also provided.

Abstract translation: 用于检测环境中的分析物的成像剂包括可以选择性地与分析物相互作用的官能化纳米金刚石和官能化磁性颗粒。 每个功能化纳米金刚石包含至少一个配置为响应照明而发光的色心。 由色心发出的光的至少一个性质与功能化磁性颗粒与着色中心的接近度有关。 可以检测该性质以确定官能化纳米金刚石接近官能化磁性颗粒，以确定官能化纳米金刚石和官能化磁性颗粒与分析物或其它应用相互作用。 还提供了通过与官能化纳米金刚石和官能化磁性颗粒相互作用来检测分析物的性质的装置和方法。

公开(公告)号：US20150238125A1

公开(公告)日：2015-08-27

申请号：US14186937

申请日：2014-02-21

Applicant: Google Inc.

Inventor： Victor Marcel Acosta ,  Vikram Singh Bajaj ,  Andrew Homyk ,  Eric Peeters ,  Jason Donald Thompson

IPC: A61B5/1459 ,  A61B5/00

CPC classification number: A61B5/14546 ,  A61B5/0022 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1477 ,  A61B5/4848 ,  A61B5/681 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/746 ,  A61B5/7475 ,  A61K49/0013 ,  A61K49/0019 ,  A61K49/0093 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  C09K11/59 ,  C23C16/27 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/1746 ,  G01N2021/6439 ,  G01R33/281 ,  G01R33/5601 ,  G02B21/00

Abstract: An imaging agent for detecting analytes in a biological environment includes functionalized, silicon vacancy center-containing nanodiamonds. Individual nanodiamonds of the imaging agent include at least one silicon vacancy center. The at least one silicon vacancy center can emit light having a wavelength in a narrow band in response to illumination having any wavelength in a wide range of wavelengths. The nanodiamonds are functionalized to selectively interact with an analyte of interest. The nanodiamonds can additionally include other color centers, and the imaging agent can include a plurality of sets of nanodiamonds having detectably unique ratios of silicon vacancy centers to other color centers. The silicon vacancy centers in the nanodiamonds can have a preferred orientation enabling orientation tracking of individual nanodiamonds or other applications. A method for detecting properties of the analyte of interest by interacting with the imaging agent is also provided.

Abstract translation: 用于检测生物环境中的分析物的成像剂包括具有功能的含空穴中心的纳米金刚石。 成像剂的单个纳米金刚石包括至少一个硅空位中心。 至少一个硅空位中心可以响应于在宽波长范围内具有任何波长的照明而发射具有窄带波长的光。 纳米金刚石被官能化以选择性地与感兴趣的分析物相互作用。 纳米金刚石可以另外包括其它颜色中心，并且成像剂可以包括具有可检测地独特的硅空位中心与其他色心的比例的多组纳米金刚石。 纳米金刚石中的硅空位中心可以具有优选的取向，使得能够对单个纳米金刚石或其它应用进行取向跟踪。 还提供了通过与成像剂相互作用来检测目的分析物的性质的方法。

公开(公告)号：US20150382105A1

公开(公告)日：2015-12-31

申请号：US14319182

申请日：2014-06-30

Applicant: Google Inc.

Inventor： Jason Donald Thompson ,  Vikram Singh Bajaj ,  Victor Marcel Acosta ,  Tamara Lynn Troy

IPC: H04R3/00 ,  A61B5/00 ,  A61B5/1455

CPC classification number: A61B5/6801 ,  A61B5/1455 ,  A61B5/681 ,  A61B5/7203 ,  A61B5/7475

Abstract: Optical measurement of physiological parameters with wearable devices often includes measuring signals in the presence of significant noise sources. These noise sources include, but are not limited to, noise associated with: variable optical coupling to skin or tissue, variations in tissue optical properties with time due to changes in humidity, temperature, hydration, variations in tissue optical properties between individuals, variable coupling of ambient light sources into detectors, and instrument and detector noise, including electrical noise, radio frequency or magnetic interference, or noise caused by mechanical movement of the detector or its components. The present disclosure includes devices and methods configured to produce representations of the raw data in which noise, broadly defined, is separated from the data of interest. The disclosed devices and methods may include subtracting or calibrating out these noise sources and other spurious fluctuations in wearable devices with optical sensors.

Abstract translation: 使用可穿戴设备的生理参数的光学测量通常包括在存在显着噪声源的情况下测量信号。 这些噪声源包括但不限于与以下相关的噪声：与皮肤或组织的可变光耦合，由于湿度变化，温度，水合，组织光学性质变化在组织光学性质随时间的变化，可变耦合 环境光源进入检测器，以及仪器和检测器噪声，包括电噪声，射频或磁干扰或由检测器或其组件的机械运动引起的噪声。 本公开包括被配置为产生原始数据的表示的设备和方法，其中广义地定义的噪声与感兴趣的数据分离。 所公开的设备和方法可以包括使用光学传感器减去或校准这些噪声源和可穿戴设备中的其他杂散波动。

公开(公告)号：US20150238636A1

公开(公告)日：2015-08-27

申请号：US14188634

申请日：2014-02-24

Applicant: Google Inc.

Inventor： Andrew Homyk ,  Victor Marcel Acosta ,  Vikram Singh Bajaj

IPC: A61K49/00 ,  A61B5/00 ,  A61B5/1455

CPC classification number: G01N33/54333 ,  A61B5/0022 ,  A61B5/0051 ,  A61B5/0093 ,  A61B5/0095 ,  A61B5/05 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/1468 ,  A61B5/681 ,  A61B5/7435 ,  A61B8/4227 ,  A61B8/481 ,  A61K49/0017 ,  A61K49/0067 ,  A61K49/0093 ,  A61K49/1827 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/00 ,  G01N33/54346 ,  G01N33/54366 ,  G01N33/588 ,  G01R33/5601

Abstract: An engineered particle for detecting analytes in an environment includes an electromagnetic receiver that is configured to preferentially receive electromagnetic radiation of a specified polarization relative to the orientation of the electromagnetic receiver. The engineered particle additionally includes an energy emitter coupled to the electromagnetic receiver such that a portion of electromagnetic energy received by the electromagnetic receiver is transferred to and emitted by the energy emitter. The engineered particles are functionalized to selectively interact with an analyte. The engineered particle can additionally be configured to align with a directed energy field in the environment. The selective reception of electromagnetic radiation of a specified polarization and/or alignment with a directed energy field can enable orientation tracking of individual engineered particles, imaging in high-noise environments, or other applications. A method for detecting properties of the analyte of interest by interacting with the engineered particle is also provided.

Abstract translation: 用于检测环境中的分析物的工程颗粒包括电磁接收器，其被配置为优先接收相对于电磁接收器的取向的指定极化的电磁辐射。 工程颗粒另外包括耦合到电磁接收器的能量发射器，使得由电磁接收器接收的电磁能量的一部分被转移到能量发射器并由能量发射器发射。 工程化的颗粒被功能化以选择性地与分析物相互作用。 工程颗粒还可以被配置为与环境中的定向能量场对准。 选择性地接收具有定向能量场的指定极化和/或对准的电磁辐射可以实现各个工程化颗粒的取向跟踪，在高噪声环境中的成像或其它应用。 还提供了通过与工程化颗粒相互作用来检测目标分析物的性质的方法。