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    Methods for reducing noise in optical biological sensors
    1.
    发明申请
    Methods for reducing noise in optical biological sensors 审中-公开
    降低光学生物传感器噪音的方法

    公开(公告)号：US20150382105A1

    公开(公告)日：2015-12-31

    申请号：US14319182

    申请日：2014-06-30

    Applicant: Google Inc.

    Inventor： Jason Donald Thompson ,  Vikram Singh Bajaj ,  Victor Marcel Acosta ,  Tamara Lynn Troy

    IPC: H04R3/00 ,  A61B5/00 ,  A61B5/1455

    CPC classification number: A61B5/6801 ,  A61B5/1455 ,  A61B5/681 ,  A61B5/7203 ,  A61B5/7475

    Abstract: Optical measurement of physiological parameters with wearable devices often includes measuring signals in the presence of significant noise sources. These noise sources include, but are not limited to, noise associated with: variable optical coupling to skin or tissue, variations in tissue optical properties with time due to changes in humidity, temperature, hydration, variations in tissue optical properties between individuals, variable coupling of ambient light sources into detectors, and instrument and detector noise, including electrical noise, radio frequency or magnetic interference, or noise caused by mechanical movement of the detector or its components. The present disclosure includes devices and methods configured to produce representations of the raw data in which noise, broadly defined, is separated from the data of interest. The disclosed devices and methods may include subtracting or calibrating out these noise sources and other spurious fluctuations in wearable devices with optical sensors.

    Abstract translation: 使用可穿戴设备的生理参数的光学测量通常包括在存在显着噪声源的情况下测量信号。 这些噪声源包括但不限于与以下相关的噪声：与皮肤或组织的可变光耦合，由于湿度变化，温度，水合，组织光学性质变化在组织光学性质随时间的变化，可变耦合 环境光源进入检测器，以及仪器和检测器噪声，包括电噪声，射频或磁干扰或由检测器或其组件的机械运动引起的噪声。 本公开包括被配置为产生原始数据的表示的设备和方法，其中广义地定义的噪声与感兴趣的数据分离。 所公开的设备和方法可以包括使用光学传感器减去或校准这些噪声源和可穿戴设备中的其他杂散波动。

    Applications of hyperspectral laser speckle imaging
    2.
    发明申请
    Applications of hyperspectral laser speckle imaging 有权
    超光谱激光斑点成像的应用

    公开(公告)号：US20160198961A1

    公开(公告)日：2016-07-14

    申请号：US14596952

    申请日：2015-01-14

    Applicant: Google Inc.

    Inventor： Andrew Homyk ,  Jason Donald Thompson

    IPC: A61B5/026 ,  A61B5/00

    CPC classification number: A61B5/0075 ,  A61B5/0066 ,  A61B5/0082 ,  A61B5/0261 ,  A61B5/681 ,  A61B5/72

    Abstract: Systems and methods are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with two or more beams of coherent light and detecting responsively emitted light. A difference in wavelength, coherence length, beam divergence, or some other property of the beams of illumination causes the beams to preferentially scatter from, be absorbed by, or otherwise interact with respective elements of the biological tissue. Flow properties in one or more regions of the biological tissue (e.g., a region with which both beams of light preferentially interact, a region with which only one of the beams preferentially interacts) could be determined based on detected responsively emitted light from the biological tissue. Variations in speckle patterns over time and/or space, Doppler shifts, or some other properties of the detected light could be used to determine the flow properties.

    Abstract translation: 提供了用于通过用两个或更多个相干光束照射生物组织并检测响应性发射的光来检测生物组织中血液或其它流体的流动的系统和方法。 波长，相干长度，光束发散或照明光束的某些其他特性的差异导致光束优先从生物组织的相应元件散射，被其吸收或以其他方式相互作用。 可以基于检测到的来自生物组织的响应发射光来确定生物组织的一个或多个区域（例如，两个光束优先相互作用的区域，只有一个光束优先相互作用的区域）的流动特性 。 随着时间和/或空间的斑点图案的变化，多普勒频移或检测到的光的某些其他特性可用于确定流动特性。

    Positioning a wearable device for data collection
    3.
    发明申请
    Positioning a wearable device for data collection 有权
    定位用于数据收集的可穿戴设备

    公开(公告)号：US20160007925A1

    公开(公告)日：2016-01-14

    申请号：US14329341

    申请日：2014-07-11

    Applicant: Google Inc.

    Inventor： Russell Norman Mirov ,  Andrew Homyk ,  Mark West Askew ,  Jason Donald Thompson

    IPC: A61B5/00 ,  G01B11/14

    CPC classification number: A61B5/00 ,  A61B5/0022 ,  A61B5/0059 ,  A61B5/02427 ,  A61B5/489 ,  A61B5/6801 ,  A61B5/6802 ,  A61B5/681 ,  A61B5/70 ,  A61B2562/043 ,  G01B11/14

    Abstract: Wearable devices are described herein including at least two photodetectors and a mount configured to mount the at least two photodetectors to an external surface of a wearer. The at least two photodetectors are configured to detect alignment between the wearable device and a target on or in the body of the wearer (e.g., to detect the location of vasculature within the body of the wearer relative to the at least two photodetectors). Alignment of the at least two photodetectors relative to the target could enable detection of one or more physiological properties of the wearer. For example, the wearable device could include a sensor configured to detect a property of the target when the sensor is above the target, and alignment of the target relative to the at least two photodetectors could include the sensor being located above the target.

    Abstract translation: 本文描述了可穿戴设备，其包括至少两个光电检测器和被配置为将至少两个光电检测器安装到穿戴者的外表面的安装座。 所述至少两个光电检测器被配置为检测穿戴式装置与佩戴者身体上或身体中的目标之间的对准（例如，以相对于至少两个光电探测器检测穿戴者身体内脉管系统的位置）。 至少两个光电检测器相对于目标的对准可以使得能够检测穿戴者的一个或多个生理特性。 例如，可穿戴设备可以包括传感器，其被配置为当传感器在目标上方时检测目标的属性，并且目标相对于至少两个光电检测器的对准可以包括位于目标上方的传感器。

    Method for using nanodiamonds to detect nearby magnetic nanoparticles
    4.
    发明申请
    Method for using nanodiamonds to detect nearby magnetic nanoparticles 有权
    使用纳米金刚石检测附近磁性纳米粒子的方法

    公开(公告)号：US20150377865A1

    公开(公告)日：2015-12-31

    申请号：US14318220

    申请日：2014-06-27

    Applicant: Google Inc.

    Inventor： Victor Marcel Acosta ,  Vikram Singh Bajaj ,  Jason Donald Thompson ,  Eric Peeters

    IPC: G01N33/50 ,  A61B5/1455

    CPC classification number: A61K49/005 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/1455 ,  A61B2576/00 ,  A61K49/0002 ,  A61K49/001 ,  A61M5/007 ,  G01N33/5091 ,  G01N33/54333 ,  G01N33/54346 ,  G01N33/544 ,  G01N33/551

    Abstract: An imaging agent for detecting analytes in an environment includes functionalized nanodiamonds and functionalized magnetic particles that can selectively interact with an analyte. Each functionalized nanodiamond contains at least one color center configured emit light in response to illumination. At least one property of the light emitted by the color centers is related to the proximity of the functionalized magnetic particles to the color centers. This property can be detected to determine that the functionalized nanodiamonds are proximate to the functionalized magnetic particles, to determine that the functionalized nanodiamonds and the functionalized magnetic particles are interacting with the analyte, or other applications. Devices and methods for detecting properties of the analyte by interacting with the functionalized nanodiamonds and functionalized magnetic particles are also provided.

    Abstract translation: 用于检测环境中的分析物的成像剂包括可以选择性地与分析物相互作用的官能化纳米金刚石和官能化磁性颗粒。 每个功能化纳米金刚石包含至少一个配置为响应照明而发光的色心。 由色心发出的光的至少一个性质与功能化磁性颗粒与着色中心的接近度有关。 可以检测该性质以确定官能化纳米金刚石接近官能化磁性颗粒，以确定官能化纳米金刚石和官能化磁性颗粒与分析物或其它应用相互作用。 还提供了通过与官能化纳米金刚石和官能化磁性颗粒相互作用来检测分析物的性质的装置和方法。

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