公开(公告)号：GB2464200A

公开(公告)日：2010-04-14

申请号：GB0917359

申请日：2009-10-02

Applicant: HABIB NAGY A ,  GORDON MYRTLE

Inventor： HABIB NAGY A ,  GORDON MYRTLE

IPC: A61K35/12 ,  A61K38/02 ,  A61K38/17 ,  A61K38/19 ,  A61K38/20 ,  A61K38/36 ,  A61P35/00

Abstract: The conditioned medium from ECACC 04092401 Omnicytes, which are CD34+, wherein that medium comprises apoptosis modulating agents. Preferably the medium is for therapeutic use in the treatment of a hyperproliferative disorder such as skin disorders or cancer and particularly non-small cell lung carcinoma. The conditioned medium may have activity to promote the apoptosis of rapidly dividing cells or to promote the survival of slowly dividing cells and its activity is blocked by TNF-alpha blocking antibodies. Also disclosed is conditioned medium from other stem cells, particularly CD34+ stem cells having pluripotency and the ability to adhere plastic, for therapeutic use in the treatment of cancers and hyperproliferative disorders and in vitro use for apoptosis activation or inhibition.