公开(公告)号：WO1994012223A1

公开(公告)日：1994-06-09

申请号：PCT/US1993010484

申请日：1993-11-02

Applicant: HAEMONETICS CORPORATION

Inventor： HAEMONETICS CORPORATION ,  FELL, Claude ,  PAPILLON, Jean

IPC: A61M01/36

CPC classification number: A61M1/3693 ,  A61M1/30 ,  A61M1/304 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2205/7518

Abstract: The present invention provides an apheresis apparatus and method for separating blood. A phlebotomy needle (22) draws anticoagulated whole blood from a donor into a separation chamber (10). The separation chamber (10) separates plasma from higher density blood components. The plasma is displaced to a plasma collection bag (24). The separation process is terminated and the higher density blood components remaining in the separation chamber are diluted with saline solution (14) and are returned to the donor via the phlebotomy needle (22). Anticoagulated whole blood is drawn again from the donor into the separation chamber (10). The separation chamber (10) again separates plasma from higher density blood components in the separation chamber (10). The separation process is then terminated and the donor is disconnected. The higher density blood components remaining in the separation chamber (10) are displaced to a bag (26) for collecting higher density blood components and is rejuvenated with additive solution (12).

Abstract translation: 本发明提供了一种用于分离血液的分离装置和方法。 静脉注射针（22）将抗凝血的全血从供体吸入分离室（10）。 分离室（10）将血浆与较高密度的血液成分分离。 等离子体被置换到等离子体收集袋（24）。 分离过程终止，残留在分离室中的较高密度的血液成分用盐水溶液（14）稀释，并通过静脉注射针（22）返回给供体。 抗凝血的全血再次从供体进入分离室（10）。 分离室（10）再次将血浆与分离室（10）中较高密度的血液成分分离开。 然后分离过程终止，供体断开。 残留在分离室（10）中的较高密度的血液成分被移动到用于收集更高密度血液成分的袋（26），并且用添加剂溶液（12）再生。

公开(公告)号：WO1994021311A3

公开(公告)日：1994-09-29

申请号：PCT/US1994001686

申请日：1994-02-15

Applicant: HAEMONETICS CORPORATION

Inventor： HAEMONETICS CORPORATION ,  HERRIG, Russell, L. ,  PLANTE, Joseph, R. ,  ANDERSON, Frank, J. ,  VOLPINI, Paul, M. ,  COMEAU, Norbert, J.

IPC: A61M01/36

公开(公告)号：WO1993000941A2

公开(公告)日：1993-01-21

申请号：PCT/US1992005359

申请日：1992-06-24

Applicant: HAEMONETICS CORPORATION

Inventor： HAEMONETICS CORPORATION ,  BARONE, David ,  HERRIG, Russell ,  KALESKAS, Edward ,  PORRECA, Ronald ,  STENFORS, Alan, L. ,  VANDOR, Robert ,  MEDBERRY, Joseph, M. ,  VOLPINI, Paul, M.

IPC: A61M01/36

CPC classification number: A61M1/3621 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2205/12 ,  A61M2205/128 ,  Y10T137/87861

Abstract: A fluid flow apparatus (10) includes a peristaltic pump rotor (20) mounted to a deck module assembly. A disposable software set is provided which includes a cassette (24) which has a primary flexible tube (34) and a pump platen (60) adjacent to which the primary flexible tube resides. Tubing with blood processing bags (54, 56, 58) are coupled to the manifold (32) along with the input port (40) of the rotor of a disposable blood processing centrifuge bowl (40). The cassette is removably secured to the hardware apparatus such that the flexible tube contacts both the platen of the cassette and the rollers of the pump rotor. The pump rotor is rotated to induce a fluid flow through the primary flexible tube. The software set also includes a three-to-one manifold which connects the primary tube to a plurality of secondary flexible tubes. Fluid flow through the secondary flexible tubes is controlled by a plurality of pinch valves which pinch the secondary tubes closed against closing surfaces on the cassette. A deck module assembly allows a user to properly secure the cassette relative to the pump rotor and the pinch valves.

Abstract translation: 包括安装在模块化组件上的蠕动泵转子的流动装置。 一次性装置由带有柔性主管和位于柔性管旁边的泵板的盒子组成。 管和血液处理袋连接到歧管和离心式一次性血液处理碗的转子入口端口。 盒子可拆卸地连接到设备上，使得柔性管子与盒子的压板和泵转子的辊子都接触。 泵转子旋转以引起柔性主管中的流动。 一次性组件还包括将主管连接到多个次级柔性管的“三合一”歧管。 通过这些辅助柔性管的流量由多个节流阀调节，这些节流阀将辅助管夹紧在盒的闭合面上以关闭它们。 模块化组件允许用户相对于泵转子和节流阀正确定位卡匣。

公开(公告)号：WO1994025086A1

公开(公告)日：1994-11-10

申请号：PCT/US1994001107

申请日：1994-02-15

Applicant: HAEMONETICS CORPORATION

Inventor： HAEMONETICS CORPORATION ,  LATHAM, Allen, Jr. ,  JORGENSEN, Glen, E. ,  SIBINGA, Theodoor, Henri, Smit ,  PLANTE, Joseph, R. ,  KNAPP, Tracey, E.

IPC: A61M01/36

CPC classification number: A61M1/3693 ,  A61M1/30 ,  A61M1/304 ,  A61M1/3696 ,  A61M2205/331 ,  B04B2005/0464 ,  B04B2005/0471

Abstract: An apheresis apparatus and method is disclosed for increasing the purity and yield of platelets separated from donated whole blood in a centrifuge (11). The whole blood in the centrifuge (11) is diluted by recirculating fluid, such as plasma or saline, at a first flow rate, to mix with further withdrawn whole blood prior to entering the centrifuge. As plasma is collected (in plasma/air bag (18)), it is recirculated (via line 40) through the centrifuge (11) at a second flow rate to further improve the separation between the intermediate density components, i.e., platelets and white blood cells in the "buffy coat". The plasma is then recirculated through the centrifuge at a third flow rate and platelets are displaced out of the centrifuge while the plasma is recirculating through the centrifuge at the third flow rate.

Abstract translation: 公开了一种用于提高在离心机（11）中从捐献的全血分离的血小板的纯度和产量的单采血液分离装置和方法。 离心机（11）中的全部血液以再循环流体如血浆或盐水以第一流速稀释，以便在进入离心机之前与进一步抽出的全血混合。 当血浆被收集（在等离子体/气囊（18））中时，其以第二流速再循环通过离心机（11），以进一步改善中间密度组分即血小板和白细胞之间的分离 血细胞在“血沉棕黄层”。 然后等离子体以第三流速再循环通过离心机，血小板以第三流速再循环通过离心机，血小板从离心机中移出。

公开(公告)号：WO1994005349A1

公开(公告)日：1994-03-17

申请号：PCT/US1993007404

申请日：1993-08-06

Applicant: HAEMONETICS CORPORATION

Inventor： HAEMONETICS CORPORATION ,  PAPILLON, Jean ,  YORK, Frederick, J.

IPC: A61M01/36

CPC classification number: A61M1/3693 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3696 ,  A61M2205/3393

Abstract: The length of time required to draw, centrifugally separate, harvest blood components and return blood components is reduced by providing a two-arm pheresis system in which blood is drawn from one arm (32), anticoagulated and pumped into an input reservoir (24) then transferred into a centrifuge bowl (10) for separation, while separated blood components are harvested and returned to the donor from an output reservoir (62) via another arm (34).

Abstract translation: 抽取离心分离，收集血液成分和返回血液成分所需的时间长度通过提供双臂血液分离系统而减少，其中血液从一个臂（32）中抽出，抗凝和泵入输入储器（24） 然后转移到离心机碗（10）中进行分离，同时收集分离的血液成分，并通过另一个臂（34）从输出贮存器（62）返回到供体。

公开(公告)号：WO1990007383A1

公开(公告)日：1990-07-12

申请号：PCT/US1989005730

申请日：1989-12-27

Applicant: HAEMONETICS CORPORATION

Inventor： HAEMONETICS CORPORATION ,  PAGES, Etienne

IPC: B04B07/08

CPC classification number: A61M39/28 ,  A61M1/3692 ,  A61M1/3696 ,  A61M39/223 ,  B04B5/0442 ,  B04B7/08 ,  B04B2005/0464

Abstract: An improved disposable blood processing centrifuge bowl is described comprising a rotary seal (28) enclosing an aperture in a bowl body (12) through which a two-piece core assembly (8, 6) is inserted.

Abstract translation: 描述了一种改进的一次性血液处理离心机碗，其包括在碗体（12）中包围孔的旋转密封件（28），两片式芯组件（8,6）穿过该密封件插入。

公开(公告)号：WO1989001827A1

公开(公告)日：1989-03-09

申请号：PCT/US1988002964

申请日：1988-08-23

Applicant: HAEMONETICS CORPORATION

Inventor： HAEMONETICS CORPORATION ,  FELL, Claude ,  PAGES, Etienne ,  UHLMANN, Dominique

IPC: B04B07/00

CPC classification number: G01L9/14 ,  A61M1/3693 ,  A61M1/3696 ,  B04B5/0442 ,  B04B7/08 ,  B04B2005/0464 ,  G01L9/0004

Abstract: A portable centrifuge apparatus for use with a centrifuge bowl having a seamless, unitary blow molded bowl body for the separation of blood into less dense and more dense components. A light weight, hand-held cabinet houses the centrifuge, and auxiliary equipment such as blood pumps, control instrumentation, and a sensor for measuring fluid pressure in a disposable chamber used for filtering blood.

公开(公告)号：WO1996012511A1

公开(公告)日：1996-05-02

申请号：PCT/US1995013549

申请日：1995-10-16

Applicant: HAEMONETICS CORPORATION

Inventor： HAEMONETICS CORPORATION ,  JONES, James, W. ,  MARSHALL, William, H. ,  WILLIAMS, Robert, E.

IPC: A61M01/00

CPC classification number: A61M1/0001 ,  A61M1/0076 ,  A61M1/0084 ,  A61M1/02 ,  A61M1/024

Abstract: A system for continuous withdrawal of blood and other fluids from a chest cavity and continuous reinfusion of such blood and other fluids into the patient, includes a withdrawal member for insertion into the chest or other wound cavity, the withdrawal member including a blood removal chamber which extends into the chest cavity of the patient. Flow of blood and other fluids from the chest cavity into the withdrawal member is controlled by a one-way valve, such as a Heimlich valve. The withdrawal or pump-tube member includes a central tubular member which extends outwardly of the pump-tube member with an annular chamber being formed between the central withdrawal tubular member and the outer wall of the pump-tube apparatus. A supply of ambient air and one or more maintenance fluids are delivered into the annular area of the pump-tube apparatus for convergence in a blood removal chamber portion such that blood which has passed through the Heimlich valve is aspirated and flowed into the withdrawal tube. The withdrawal tube is connected to a collection chamber which itself is under vacuum to cooperate in the removal of the blood and any maintenance fluids from the pump-tube apparatus for collection in the collection chamber. A reinfusion line is connected to the collection chamber for attachment to the patient such that blood is continually withdrawn from the patient's chest area during and after surgery and continuously re-infused into the patient with a minimum amount of exposure to foreign substances.

Abstract translation: 用于从胸腔连续取出血液和其他流体并将这种血液和其它流体连续输回到患者体内的系统包括用于插入胸部或其他伤口腔的取出构件，所述抽出构件包括除血室 延伸到患者的胸腔。 血液和其他流体从胸腔流入取出部件由单向阀（如Heimlich阀）控制。 抽出或泵管构件包括中央管状构件，其在泵管构件的外部延伸，环形室形成在中央抽出管状构件和泵管装置的外壁之间。 将环境空气和一个或多个维护流体供应到泵管装置的环形区域中，用于聚集在除血室部分中，使得已经通过Heimlich阀的血液被吸入并流入抽出管。 抽出管连接到收集室，该收集室本身处于真空状态，用于合并血液和来自泵管装置的任何维护流体，用于收集在收集室中。 回收线连接到收集室以附着到患者​​，使得在手术期间和手术后血液不断地从患者胸部区域中取出，并以最少量的外来物质暴露于患者体内。

公开(公告)号：WO1994008721A1

公开(公告)日：1994-04-28

申请号：PCT/US1993009276

申请日：1993-09-29

Applicant: HAEMONETICS CORPORATION

Inventor： HAEMONETICS CORPORATION ,  HEADLEY, Thomas, D. ,  CHAMMAS, Jacques

IPC: B04B05/04

CPC classification number: B04B5/0442 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  B04B5/0407 ,  B04B7/08 ,  B04B2005/0464

Abstract: An improved centrifuge rotor formed of a bowl body (12) and core (8) for blood processing applications, such as cell washing or pheresis, is described. A tubular core (8) adapted to rotate with the rotor defines a processing region between the core (8) and the interior of the bowl (12) body. A plurality of projections (4) extend into the processing region to minimize formation of fluid Coriolis waves which would otherwise cause undesirable turbulence.

Abstract translation: 描述了由用于血液处理应用的碗体（12）和芯（8）形成的改进的离心机转子，例如细胞洗涤或去血浆。 适于与转子一起旋转的管状芯部（8）限定了芯部（8）和碗状物（12）内部之间的加工区域。 多个突起（4）延伸到处理区域中以最小化流体科里奥利波的形成，否则这将导致不期望的湍流。

公开(公告)号：WO1989001792A1

公开(公告)日：1989-03-09

申请号：PCT/US1988002963

申请日：1988-08-23

Applicant: HAEMONETICS CORPORATION

Inventor： HAEMONETICS CORPORATION ,  LUEPTOW, Richard, M. ,  HEADLEY, Thomas, D.

IPC: A61M01/36

CPC classification number: B04B5/0442 ,  A61M1/025 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M39/223 ,  A61M39/28 ,  B04B2005/0464

Abstract: A method and apparatus for concentrating red blood cells and washing said cells to remove supernatant is described wherein blood is centrifuged in a core-less integral centrifuge bowl at a predetermined speed to pack the more dense red cells leaving a toroidal layer of less dense supernatant. Cell washing fluid displaces the supernatant from the bowl. A mixing cycle is established wherein the centrifuge is slowed down to mix the washing fluid and red cells. The centrifuge is then returned to speed and further washing fluid is introduced. The mixing cycle is successively repeated until a satisfactory washout is established.

Abstract translation: 描述了用于浓缩红细胞并洗涤所述细胞以除去上清液的方法和装置，其中将血液以无预定的整体离心机碗以预定速度离心以包装较密实的红细胞，留下较不致密的上清液的环形层。 细胞洗涤液从碗中取代上清液。 建立混合循环，其中离心机减速以混合洗涤液和红细胞。 然后离心机返回速度，并进一步引入洗涤液。 连续重复混合循环，直到确定满意的冲洗。