公开(公告)号：DE69417473T2

公开(公告)日：1999-09-30

申请号：DE69417473

申请日：1994-06-09

Applicant: HAMAMATSU PHOTONICS KK

Inventor： ODA MOTOKI ,  YAMASHITA YUTAKA ,  OHTA KAZUYOSHI ,  TAMURA MAMORU ,  NISHIMURA GORO

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  G01N21/17 ,  G01N21/27 ,  G01N21/49 ,  G01N21/47

Abstract: An optical pulse emitted from an optical pulse source is incident on a living tissue and is input to an optical sampling unit. The optical sampling unit detects intensities f of optical pulses detected at the respective timings of trigger signals input from a delay unit. A first accumulator calculates products t.f of the intensities f and the delay times t from the delay unit. A second accumulator accumulates the light intensities f. An average optical pathlength calculating unit calculates an average optical pathlength using the accumulation results as the products t.f and the intensities f. An SO2 value calculating unit calculates a ratio of VHbO2 to VHb from the average optical pathlength to calculate an SO2 value.

公开(公告)号：DE69417473D1

公开(公告)日：1999-05-06

申请号：DE69417473

申请日：1994-06-09

Applicant: HAMAMATSU PHOTONICS KK

Inventor： ODA MOTOKI ,  YAMASHITA YUTAKA ,  OHTA KAZUYOSHI ,  TAMURA MAMORU ,  NISHIMURA GORO

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  G01N21/17 ,  G01N21/27 ,  G01N21/49 ,  G01N21/47

Abstract: An optical pulse emitted from an optical pulse source is incident on a living tissue and is input to an optical sampling unit. The optical sampling unit detects intensities f of optical pulses detected at the respective timings of trigger signals input from a delay unit. A first accumulator calculates products t.f of the intensities f and the delay times t from the delay unit. A second accumulator accumulates the light intensities f. An average optical pathlength calculating unit calculates an average optical pathlength using the accumulation results as the products t.f and the intensities f. An SO2 value calculating unit calculates a ratio of VHbO2 to VHb from the average optical pathlength to calculate an SO2 value.

公开(公告)号：JPH0682096B2

公开(公告)日：1994-10-19

申请号：JP32210590

申请日：1990-11-26

Applicant: HAMAMATSU PHOTONICS KK

Inventor： ODA MOTOKI ,  YAMASHITA YUTAKA ,  OOTA KAZUYOSHI ,  TAMURA MAMORU ,  NISHIMURA GORO

IPC: G01N21/49 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/14

公开(公告)号：JPH04191642A

公开(公告)日：1992-07-09

申请号：JP32210590

申请日：1990-11-26

Applicant: HAMAMATSU PHOTONICS KK

Inventor： ODA MOTOKI ,  YAMASHITA YUTAKA ,  OTA KAZUYOSHI ,  TAMURA MAMORU ,  NISHIMURA GORO

IPC: G01N21/49 ,  A61B5/145 ,  A61B5/1455

Abstract: PURPOSE:To detect an absolute value of the concentration of hemoglobin in blood, for instance, in addition to the state of a change in an organism by applying a pulse light to a scattering medium containing a light-absorbing substance. CONSTITUTION:Five kinds of pulse lights selected from a wavelength band of 670nm to 1.33mum are applied to a scattering medium containing oxidation-type hemoglobin, reduction-type hemoglobin, cytochrome and myoglobin, for instance, and the intensity of light for each wavelength is measured. Utilizing that a scattering profile in the case when no light-absorbing substance exists in the scattering medium does not change according to the wavelength, the scattering profile is removed from simultaneous equations of a time-base profile of the intensity of light for each wavelength obtained herein and the scattering profile, and thereby concentration V is obtained. The concentration V is calculated by the equation on the right. In the equation, K denotes a constant of absorption of lights of wavelengths lambda1 and lambda2, C denotes the velocity of light in the scattering medium, f1 denotes the light intensity of the light of the wavelength lambda1 at times t1 and t2, and f2 denotes the light intensity of the light of the wavelength lambda2 at the times t1 and t2.

公开(公告)号：JP2003202287A

公开(公告)日：2003-07-18

申请号：JP2002001564

申请日：2002-01-08

Applicant: HAMAMATSU PHOTONICS KK

Inventor： KORI SHUNJI ,  HOSHI SHIYOUKO ,  TAMURA MAMORU

IPC: G01N21/17 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00

Abstract: PROBLEM TO BE SOLVED: To measure the variation of an absorption coefficient of only a measuring object area by eliminating the influence of a non-measurement object area in a case when a measuring object area and the non-measuring object area exist in a scattering absorption member as a measuring object when the scattering absorption member is measured. SOLUTION: The pulse light of a predetermined wavelength incoming from a light incoming position S1 by a light injecting means 10, reaches optical detecting positions D1, D2 through each optical path while scattering, to be detected by an optical detecting means 20. A time waveform of the detected light is generated in a signal processing means 30 by using a detection signal generated by the optical detecting means 20. The variation of the absorbing coefficient of only the measuring object area is calculated by an operating means 40 on the basis of the time waveform assuming that a partial optical path length propagating the non-measuring object region Me is constant regardless of the optical path. COPYRIGHT: (C)2003,JPO

公开(公告)号：JPH06343625A

公开(公告)日：1994-12-20

申请号：JP13873693

申请日：1993-06-10

Applicant: HAMAMATSU PHOTONICS KK

Inventor： ODA MOTOKI ,  YAMASHITA YUTAKA ,  OTA KAZUYOSHI ,  TAMURA MAMORU ,  NISHIMURA GORO

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  G01N21/17 ,  G01N21/27 ,  G01N21/49 ,  A61B5/14

Abstract: PURPOSE:To provide a method and device for measuring the concentration of the light absorptive substance in a diffusing medium simply and accurately using a simple device configuration. CONSTITUTION:A light pulse emitted by a light pulse source 21 is put incident to a vital organism structure 23 through an optical fiber 22 and entered into a light sapling part 25 through another optical fiber 24. The sampling part 25 senses the intensity (f) of each light pulse sensed at each trigger signal input timing from a delay device 26. The first cumulation part 27 calculates the product t.f of the sensed photo-intensity (f) and the delay time (t) given by the delay device 26, while the second cumulation part 28 cumulates the photo- intensity (f). A mean light, path length calculation part 29 calculates the mean light path length using the cumulative results of the product t.f and photo- intensity (f). An SO2 value calculation part 30 determines the concentration ratio of VHbO2 to VHb from the mean light path length obtained, and the SO2 value is calculated. A display part 31 displays the SO2 value.