公开(公告)号：AU2009282480B2

公开(公告)日：2015-05-07

申请号：AU2009282480

申请日：2009-08-11

Applicant: CHILDRENS MEDICAL CENTER ,  HARVARD COLLEGE

Inventor： KELLER TRACY ,  MAZITSCHEK RALPH ,  WHITMAN MALCOLM ,  LEE JINBO

IPC: C07D401/14 ,  A61K31/505 ,  A61K31/517 ,  A61P29/00 ,  A61P35/00 ,  C07D403/14

Abstract: The present invention provides novel analogs and derivatives of halofuginone. The invention also provides pharmaceutical and cosmetic compositions thereof and methods for using halofuginone analogs in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, viral infections, ischemic damage, transplant and implant rejection, neurodegenerative diseases, and cosmetic applications.

公开(公告)号：AU2013207796A1

公开(公告)日：2014-08-07

申请号：AU2013207796

申请日：2013-01-11

Applicant: HARVARD COLLEGE ,  GEN HOSPITAL CORP

Inventor： WHITMAN MALCOLM ,  KELLER TRACY ,  MAZITSCHEK RALPH

IPC: C07D403/06 ,  A61K8/49 ,  A61K31/517 ,  A61K45/06 ,  A61P3/10 ,  A61P9/00 ,  A61P11/06 ,  A61P29/02 ,  A61P31/00 ,  A61P31/10 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61Q19/06

Abstract: The present invention provides halofuginol, and derivatives and salts thereof, including diasteromerically enriched compositions thereof. The invention also provides pharmaceutical and cosmetic compositions thereof as well as methods for using halofuginol and derivatives thereof in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, viral infections, malaria, ischemic damage, transplant rejection, neurodegenerative diseases, T-cell neoplasms, and cosmetic conditions.

公开(公告)号：CA2737219A1

公开(公告)日：2010-02-18

申请号：CA2737219

申请日：2009-08-11

Applicant: HARVARD COLLEGE

Inventor： KELLER TRACY ,  MAZITSCHEK RALPH ,  WHITMAN MALCOLM ,  LEE JINBO

IPC: C07D401/14 ,  A61K31/505 ,  A61K31/517 ,  A61P29/00 ,  A61P35/00 ,  C07D403/14

Abstract: The present invention provides novel analogs and derivatives of halofuginone. The invention also provides pharmaceutical and cosmetic compositions thereof and methods for using halofuginone analogs in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angio--genesis, viral infections, ischemic damage, transplant and implant rejection, neurodegenerative diseases, and cosmetic applications.

公开(公告)号：AU2007238816A1

公开(公告)日：2007-10-25

申请号：AU2007238816

申请日：2007-04-10

Applicant: HARVARD COLLEGE

Inventor： WHITMAN MALCOLM ,  KELLER TRACY

IPC: A61K8/49 ,  A61K31/517 ,  A61K36/00 ,  A61P17/00 ,  A61Q19/06

公开(公告)号：HK1203947A1

公开(公告)日：2015-11-06

申请号：HK15104491

申请日：2015-05-12

Applicant: HARVARD COLLEGE

Inventor： WHITMAN MALCOLM ,  KELLER TRACY ,  MAZITSCHEK RALPH

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101 ,  A61Q20060101

Abstract: The present invention provides halofuginol, and derivatives and salts thereof, including diasteromerically enriched compositions thereof. The invention also provides pharmaceutical and cosmetic compositions thereof as well as methods for using halofuginol and derivatives thereof in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, viral infections, malaria, ischemic damage, transplant rejection, neurodegenerative diseases, T-cell neoplasms, and cosmetic conditions.

公开(公告)号：AU2009282480A1

公开(公告)日：2010-02-18

申请号：AU2009282480

申请日：2009-08-11

Applicant: HARVARD COLLEGE

Inventor： KELLER TRACY ,  MAZITSCHEK RALPH ,  WHITMAN MALCOLM ,  LEE JINBO

IPC: C07D401/14 ,  A61K31/505 ,  A61K31/517 ,  A61P29/00 ,  A61P35/00 ,  C07D403/14

公开(公告)号：AU7705398A

公开(公告)日：1998-12-30

申请号：AU7705398

申请日：1998-05-28

Applicant: HARVARD COLLEGE

Inventor： WHITMAN MALCOLM ,  CHEN XIN

IPC: A61K38/00 ,  C07K14/46 ,  C07K14/47 ,  C12N1/21 ,  C12Q1/68 ,  C12Q1/6897 ,  A61K31/70 ,  C07K14/00 ,  C12N1/16 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  G01N33/53

Abstract: FAST-1 and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF-beta superfamily member. We have shown that a domain of FAST-1 directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-1. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF-beta superfamily signalling.

公开(公告)号：CA2861840C

公开(公告)日：2020-12-15

申请号：CA2861840

申请日：2013-01-11

Applicant: HARVARD COLLEGE ,  THE GENERAL HOSPITAL CORP D/B/A MASSACHUSETTS GENERAL HOSPITAL

Inventor： WHITMAN MALCOLM ,  KELLER TRACY ,  MAZITSCHEK RALPH

IPC: C07D403/06 ,  A61K8/49 ,  A61K31/517 ,  A61K45/06 ,  A61P3/10 ,  A61P9/00 ,  A61P11/06 ,  A61P29/02 ,  A61P31/00 ,  A61P31/10 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61Q19/06

Abstract: The present invention provides halofuginol, and derivatives and salts thereof, including diasteromerically enriched compositions thereof. The invention also provides pharmaceutical and cosmetic compositions thereof as well as methods for using halofuginol and derivatives thereof in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, viral infections, malaria, ischemic damage, transplant rejection, neurodegenerative diseases, T-cell neoplasms, and cosmetic conditions.

公开(公告)号：AU2013207796B2

公开(公告)日：2017-04-27

申请号：AU2013207796

申请日：2013-01-11

Applicant: HARVARD COLLEGE ,  THE GENERAL HOSPITAL CORP D/B/A MASSACHUSETTS GENERAL HOSPITAL

Inventor： WHITMAN MALCOLM ,  KELLER TRACY ,  MAZITSCHEK RALPH

IPC: C07D403/06 ,  A61K8/49 ,  A61K31/517 ,  A61K45/06 ,  A61P3/10 ,  A61P9/00 ,  A61P11/06 ,  A61P29/02 ,  A61P31/00 ,  A61P31/10 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61Q19/06

Abstract: The present invention provides halofuginol, and derivatives and salts thereof, including diasteromerically enriched compositions thereof. The invention also provides pharmaceutical and cosmetic compositions thereof as well as methods for using halofuginol and derivatives thereof in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, viral infections, malaria, ischemic damage, transplant rejection, neurodegenerative diseases, T-cell neoplasms, and cosmetic conditions.

公开(公告)号：CA2737219C

公开(公告)日：2017-02-28

申请号：CA2737219

申请日：2009-08-11

Applicant: HARVARD COLLEGE ,  CHILDREN'S MEDICAL CENTER CORP

Inventor： KELLER TRACY ,  MAZITSCHEK RALPH ,  WHITMAN MALCOLM ,  LEE JINBO ,  SUNDRUD MARK ,  RAO ANJANA

IPC: C07D401/14 ,  A61K31/505 ,  A61K31/517 ,  A61P29/00 ,  A61P35/00 ,  C07D403/14

Abstract: The present invention provides novel analogs and derivatives of halofuginone. The invention also provides pharmaceutical and cosmetic compositions thereof and methods for using halofuginone analogs in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angio--genesis, viral infections, ischemic damage, transplant and implant rejection, neurodegenerative diseases, and cosmetic applications.