公开(公告)号：EP2764255A4

公开(公告)日：2016-07-06

申请号：EP12864130

申请日：2012-10-08

Applicant: HARVARD COLLEGE

Inventor： SHEPHERD ROBERT F ,  NUNES RUI ,  WHITESIDES GEORGE M ,  STOKES ADAM ,  FREAKE JACOB ,  MORIN STEPHEN A ,  CADEMARTIRI LUDOVICO ,  CHEN XIN

IPC: B25J9/10 ,  B25J9/14

CPC classification number: F15B13/04 ,  B25J9/1075 ,  B25J9/142

Abstract: Systems and methods for providing a soft robot is provided. In one system, a robotic device includes a flexible body having a fluid chamber, where a portion of the flexible body includes an elastically extensible material and a portion of the flexible body is strain limiting relative to the elastically extensible material. The robotic device can further include a pressurizing inlet in fluid communication with the fluid chamber, and a pressurizing device in fluid communication with the pressurizing inlet, the pressurizing device including a reaction chamber configured to accommodate a gas-producing chemical reaction for providing pressurized gas to the pressurizing inlet.

Abstract translation: 提供了一种用于提供软机器人的系统和方法。 在一个系统中，机器人装置包括具有流体室的柔性体，其中柔性体的一部分包括弹性可伸长的材料，并且柔性体的一部分相对于弹性可伸长的材料是应变限制的。 机器人装置还可以包括与流体室流体连通的加压入口，以及与加压入口流体连通的加压装置，该加压装置包括反应室，该反应室被配置成容纳产生气体的化学反应以提供加压气体 加压入口。

公开(公告)号：WO2012148472A3

公开(公告)日：2013-07-25

申请号：PCT/US2011061720

申请日：2011-11-21

Applicant: HARVARD COLLEGE ,  ILIEVSKI FILIP ,  CHEN XIN ,  MAZZEO AARON D ,  WHITESIDES GEORGE M ,  SHEPHERD ROBERT ,  MARTINEZ RAMSES ,  CHOI WON JAE ,  KWOK SEN W ,  MORIN STEPHEN ,  STOKES ADAM ,  NIE ZHIHONG

Inventor： ILIEVSKI FILIP ,  CHEN XIN ,  MAZZEO AARON D ,  WHITESIDES GEORGE M ,  SHEPHERD ROBERT ,  MARTINEZ RAMSES ,  CHOI WON JAE ,  KWOK SEN W ,  MORIN STEPHEN ,  STOKES ADAM ,  NIE ZHIHONG

IPC: B25J9/00

CPC classification number: F15B15/10 ,  B25J9/1075 ,  B25J9/142 ,  B25J11/00 ,  F15B7/06

Abstract: A soft robotic device includes a flexible body having a width, a length and a thickness, wherein the thickness is at least 1 mm, the flexible body having at least one channel disposed within the flexible body, the channel defined by upper, lower and side walls, wherein at least one wall is strain limiting; and a pressurizing inlet in fluid communication with the at least one channel, the at least one channel positioned and arranged such that the wall opposite the strain limiting wall preferentially expands when the soft robotic device is pressurized through the inlet.

Abstract translation: 软机器人装置包括具有宽度，长度和厚度的柔性体，其中所述厚度为至少1mm，所述柔性体具有设置在所述柔性体内的至少一个通道，所述通道由上，下和侧限定 壁，其中至少一个壁是应变限制; 以及与所述至少一个通道流体连通的加压入口，所述至少一个通道定位和布置成使得当所述软自动装置通过所述入口被加压时，与所述应变限制壁相对的壁优先地膨胀。

公开(公告)号：CA2754577C

公开(公告)日：2018-07-10

申请号：CA2754577

申请日：2010-03-08

Applicant: HARVARD COLLEGE

Inventor： NIE ZHIHONG ,  NIJHUIS CHRISTIAN ,  CHEN XIN ,  MARTINEZ ANDRES W ,  NAROVLYANSKY MAX ,  WHITESIDES GEORGE M

IPC: B01L3/00

Abstract: Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic commu-nication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a ref-erence electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of as-sembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

公开(公告)号：ES2612507T3

公开(公告)日：2017-05-17

申请号：ES10712600

申请日：2010-03-08

Applicant: HARVARD COLLEGE

Inventor： NIE ZHIHONG ,  NIJHUIS CHRISTIAN ,  CHEN XIN ,  MARTINEZ ANDRES ,  NAROVLYANSKY MAX ,  WHITESIDES GEORGE

IPC: B01L3/00

Abstract: Un dispositivo microfluídico y electroquímico que comprende: un primer ensamble de electrodo que comprende una primera capa de sustrato (103) que soporta uno o más electrodos (101); y una primera capa hidrófila porosa (107) que se superpone al ensamble de electrodo, en donde la capa hidrófila comprende un límite impermeable a los fluidos que permea sustancialmente el grosor de la capa hidrófila y define uno o más canales hidrófilos(108) dentro de la capa hidrófila, en donde uno o más canales hidrófilos comprenden una primera región hidrófila (104) que está en comunicación fluídica con uno o más electrodos.

公开(公告)号：AU7705398A

公开(公告)日：1998-12-30

申请号：AU7705398

申请日：1998-05-28

Applicant: HARVARD COLLEGE

Inventor： WHITMAN MALCOLM ,  CHEN XIN

IPC: A61K38/00 ,  C07K14/46 ,  C07K14/47 ,  C12N1/21 ,  C12Q1/68 ,  C12Q1/6897 ,  A61K31/70 ,  C07K14/00 ,  C12N1/16 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  G01N33/53

Abstract: FAST-1 and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF-beta superfamily member. We have shown that a domain of FAST-1 directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-1. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF-beta superfamily signalling.

公开(公告)号：ES2836002T3

公开(公告)日：2021-06-23

申请号：ES12864130

申请日：2012-10-08

Applicant: HARVARD COLLEGE

Inventor： SHEPHERD ROBERT ,  NUNES RUI ,  WHITESIDES GEORGE ,  STOKES ADAM ,  FREAKE JACOB ,  MORIN STEPHEN ,  CADEMARTIRI LUDOVICO ,  CHEN XIN

IPC: B25J9/10 ,  B25J9/14

Abstract: Un dispositivo robótico sin conexiones, que comprende: un cuerpo flexible que tiene una cámara (100) de fluido, en donde el cuerpo flexible comprende un material (102) elásticamente extensible y una porción del cuerpo flexible comprende una capa (104) limitante de deformación que es limitante de deformación en relación con el material elásticamente extensible, en donde el cuerpo flexible está configurado para doblarse alrededor de la capa limitante de deformación tras recibir un fluido presurizado en la cámara (100) de fluido; una entrada de presurización en comunicación fluida con la cámara de fluido; y un dispositivo (404) de presurización sin conexiones en el dispositivo robótico en comunicación fluida con la entrada de presurización, en donde el dispositivo de presurización comprende una cámara de reacción configurada para acomodar uno o más reactivos productores de gas, está separado de la cámara (100) de fluido, y está configurado para generar el fluido presurizado y proporcionar el fluido presurizado a la cámara de fluido del cuerpo flexible.

公开(公告)号：PL2403645T3

公开(公告)日：2017-05-31

申请号：PL10712600

申请日：2010-03-08

Applicant: HARVARD COLLEGE

Inventor： NIE ZHIHONG ,  NIJHUIS CHRISTIAN ,  CHEN XIN ,  MARTINEZ ANDRES W ,  NAROVLYANSKY MAX ,  WHITESIDES GEORGE M

IPC: B01L3/00

公开(公告)号：CA2754577A1

公开(公告)日：2010-09-10

申请号：CA2754577

申请日：2010-03-08

Applicant: HARVARD COLLEGE

Inventor： NIE ZHIHONG ,  NIJHUIS CHRISTIAN ,  CHEN XIN ,  MARTINEZ ANDRES W ,  NAROVLYANSKY MAX ,  WHITESIDES GEORGE M

IPC: B01L3/00

Abstract: Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fiuidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.