公开(公告)号：WO0206407A3

公开(公告)日：2003-02-13

申请号：PCT/US0122455

申请日：2001-07-17

Applicant: HARVARD COLLEGE

Inventor： CHAPMAN ROBERT G ,  OSTUNI EMANUELE ,  LIANG MICHAEL N ,  YAN LIN ,  WHITESIDES GEORGE M

IPC: A61F2/28 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  C08J7/12 ,  B05D1/18

CPC classification number: B82Y30/00 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  B82Y5/00 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/268 ,  Y10T428/269 ,  Y10T428/31504 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31725 ,  Y10T428/31855

Abstract: The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

Abstract translation: 本发明提供对蛋白质，细胞和细菌的吸附有抗性的制品。 制品可以具有键合在其上的化学链，其中化学链可以包含不含氢键供体的末端基团或者氢键供体被充分掩埋，使得包含化学链的制品的暴露表面不含 氢键供体。 化学链或多个化学链可以包括单层，例如可以是均相（一种类型的SAM）或混合的，即或更多不同类型的SAM的自组装单层（SAM）。 提供了化学链的其他更具体的实例。 多个化学链可以包括诸如多胺的聚合物。 在许多方面，多个化学链足够地没有交联或分支。 本发明还提供能够特异性结合所需生物分子同时防止生物分子的非特异性结合的制品。

公开(公告)号：WO0206407A9

公开(公告)日：2003-10-23

申请号：PCT/US0122455

申请日：2001-07-17

Applicant: HARVARD COLLEGE

Inventor： CHAPMAN ROBERT G ,  OSTUNI EMANUELE ,  LIANG MICHAEL N ,  YAN LIN ,  WHITESIDES GEORGE M

IPC: A61F2/28 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  C08J7/12 ,  B05D1/18

CPC classification number: B82Y30/00 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  B82Y5/00 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/268 ,  Y10T428/269 ,  Y10T428/31504 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31725 ,  Y10T428/31855

Abstract: The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

Abstract translation: 本发明提供了抗蛋白质，细胞和细菌吸附的制品。 制品可以具有键合在其上的化学链，其中化学链可以包含不含氢键供体的末端基团，或者氢键供体被充分掩埋以使得包括化学链的制品的暴露表面不含 氢键供体。 化学链或多个化学链可以包括单层，例如可以是均质的（一种类型的SAM）或混合的，即或更多不同类型的SAM的自组装单层（SAM）。 提供了其他更具体的化学链的例子。 多个化学链可以包含聚合物如多胺。 在许多方面，多个化学链充分地没有交联或分支。 本发明还提供了能够特异性结合期望的生物分子，同时防止生物分子的非特异性结合的制品。

公开(公告)号：AU7595701A

公开(公告)日：2002-01-30

申请号：AU7595701

申请日：2001-07-17

Applicant: HARVARD COLLEGE

Inventor： CHAPMAN ROBERT G ,  OSTUNI EMANUELE ,  LIANG MICHAEL N ,  YAN LIN ,  WHITESIDES GEORGE M

IPC: A61F2/28 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  C08J7/12 ,  C09D5/14

Abstract: The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

公开(公告)号：AU2001275957B2

公开(公告)日：2007-01-11

申请号：AU2001275957

申请日：2001-07-17

Applicant: HARVARD COLLEGE

Inventor： OSTUNI EMANUELE ,  WHITESIDES GEORGE M ,  LIANG MICHAEL N ,  YAN LIN ,  CHAPMAN ROBERT G

IPC: A61F2/28 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  C08J7/12

Abstract: The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

公开(公告)号：CA2415294A1

公开(公告)日：2002-01-24

申请号：CA2415294

申请日：2001-07-17

Applicant: HARVARD COLLEGE

Inventor： LIANG MICHAEL N ,  OSTUNI EMANUELE ,  WHITESIDES GEORGE M ,  YAN LIN ,  CHAPMAN ROBERT G

IPC: A61F2/28 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  C08J7/12 ,  C09D5/14

Abstract: The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free o f a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non- specific binding of biomolecules.