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公开(公告)号：WO2019045673A1
公开(公告)日：2019-03-07
申请号：PCT/US2017/048835
申请日：2017-08-28
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： CHEN, Chien-Hua , CUMBIE, Michael , SHKOLNIKOV, Viktor
Abstract: Examples include a fluid device. The fluid device includes a substrate, a sensor coupled on the substrate. A reservoir is formed in the substrate adjacent to the sensor. A deformable cover is disposed to seal the sensor and the reservoir on the substrate.
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公开(公告)号：WO2022231611A1
公开(公告)日：2022-11-03
申请号：PCT/US2021/030081
申请日：2021-04-30
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： CUMBIE, Michael , SHKOLNIKOV, Viktor
IPC: C12Q1/6806 , B01L3/00
Abstract: A microfluidic device is described. The device comprises a reaction chamber, wherein the reaction chamber comprises at least one reaction reagent disposed on at least one inner surface of the reaction chamber. A heater is also provided. A thermally dissolvable or degradable or thermally degradable film is applied to the at least one inner surface of the reaction chamber on which the reaction reagent is disposed. Also described is a PCR apparatus and a method of performing PCR.
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公开(公告)号：WO2020068081A1
公开(公告)日：2020-04-02
申请号：PCT/US2018/053037
申请日：2018-09-27
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： CUMBIE, Michael , CHEN, Chien-Hua
Abstract: Examples include a fluid ejection device comprising a carrier, at least one fluid ejection die, and conductive traces at least partially embedded in the carrier. The carrier has a first portion and a second portion, where an angle of orientation between the first portion and the second portion is nonparallel. The first portion includes an array of openings formed through a top surface of the carrier. The second portion includes at least one die opening through a bottom surface of the carrier. The fluid ejection die is coupled to the second portion of the carrier. Fluid passages formed in a back surface of the fluid ejection die are exposed through the at least one die opening formed through the bottom surface of the carrier. The conductive traces have an array of contact points at first ends of the conductive traces. The array of contact points align with the array of openings of the first portion of the carrier such that the array of contact points are exposed through the array of openings. The conductive traces connect the fluid ejection die and the array of contact points.
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公开(公告)号：WO2015163859A1
公开(公告)日：2015-10-29
申请号：PCT/US2014/035037
申请日：2014-04-22
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： CHEN, Chien-Hua , CUMBIE, Michael , HAMMERSTAD, Diane
CPC classification number: B41J2/1433 , B41J2/1404 , B41J2002/14419 , B41J2202/20
Abstract: In one example, a fluid flow structure includes a fluid dispensing micro device embedded in a molding having a channel therein through which fluid may flow directly to the device. The device contains multiple fluid ejectors and multiple fluid chambers each near an ejector. Each chamber has an inlet through which fluid from the channel may enter the chamber and an outlet through which fluid may be ejected from the chamber. A perimeter of the channel surrounds the inlets but is otherwise unconstrained in size by the size of the device.
Abstract translation: 在一个示例中，流体流动结构包括嵌入在其中具有通道的模制件中的流体分配微型装置，流体可以通过该通道直接流向装置。 该装置包含多个流体喷射器和多个流体室，每个流体喷射器各自靠近喷射器。 每个室具有一个入口，来自该通道的流体可以通过该入口进入该室，一个出口，流体可通过该出口从该室排出。 通道的周边围绕入口，但是在尺寸上不受约束的尺寸。
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公开(公告)号：WO2023069109A1
公开(公告)日：2023-04-27
申请号：PCT/US2021/056135
申请日：2021-10-22
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： SHKOLNIKOV, Viktor , CUMBIE, Michael
Abstract: A digital droplet PCR system is described. The digital droplet PCR system comprises a microfluidic cartridge comprising: a plurality of sample droplet generators, wherein each sample droplet generator is operable to partition a PCR mixture into a plurality of aqueous droplets dispersed in a carrier liquid, and wherein at least one sample droplet generator is operable to partition a PCR mixture that is different to a PCR mixture that is partitioned by at least one other sample droplet generator; a thermocycling chamber comprising an embedded heater, an inlet configured to receive the plurality of aqueous droplets from the plurality of sample droplet generators, and an outlet; and an optical readout zone fluidly connected to the outlet of the thermocycling chamber; and a pressure-actuated pump configured to couple to and cause fluid flow through the microfluidic cartridge. A method of performing digital droplet PCR is also described.
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Patent Agency Ranking
公开(公告)号：WO2022231612A1
公开(公告)日：2022-11-03
申请号：PCT/US2021/030085
申请日：2021-04-30
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： CUMBIE, Michael , KEEFE, Brian J. , SAMLALI, Kenza , SHKOLNIKOV, Viktor
IPC: C12Q1/6806 , G01N33/569 , G01N21/68 , B01F3/08 , B81B1/00
Abstract: A PCR system is described. The PCR system comprises a thermocycling chamber comprising an electrode assembly configured to generate an electric field and cause reversible electrowetting of a PCR mixture within the thermocycling chamber; and an optical sensor configured to obtain optical signals from the thermocycling chamber. Also described is a method of manufacturing a PCR system and a method of performing PCR.
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公开(公告)号：WO2023069108A1
公开(公告)日：2023-04-27
申请号：PCT/US2021/056133
申请日：2021-10-22
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： CUMBIE, Michael , SHKOLNIKOV, Viktor , KEEFE, Brian J.
Abstract: A PCR system is described. The PCR system comprises a microfluidic cartridge having a thermocycling chamber, wherein a floor of the thermocycling chamber is substantially planar and is provided with a heater; a cooling module configured to engage with and be in thermal contact with a surface of the microfluidic cartridge; and an optical sensor configured to obtain optical signals from the thermocycling chamber. A method of performing PCR is also described.
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公开(公告)号：WO2022231608A1
公开(公告)日：2022-11-03
申请号：PCT/US2021/030076
申请日：2021-04-30
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： CUMBIE, Michael , SHKOLNIKOV, Viktor , CHEN, Chien-Hua
IPC: C12Q1/6806 , G01N33/569 , G01N23/20033 , B01F3/08 , B81B1/00
Abstract: A microfluidic device is described. The microfluidic device comprises a reaction chamber and a temperature control module overlaying the reaction chamber. The temperature control module comprises a temperature regulating flow channel disposed between two layers and in thermal contact with the reaction chamber, and wherein at least a portion of each layer comprises an optically transparent material. Also described is a method of manufacturing a microfluidic device and a method of controlling temperature of a reaction in a microfluidic device.
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公开(公告)号：WO2022231607A1
公开(公告)日：2022-11-03
申请号：PCT/US2021/030074
申请日：2021-04-30
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： OLSEN, David , CUMBIE, Michael , SHKOLNIKOV, Viktor
IPC: C12Q1/6806 , G01N33/569 , B01F3/08 , B81B1/00
Abstract: A microfluidic device is described. The device comprises a flow channel; and at least one reaction chamber. The at least one reaction chamber comprises a chamber inlet connecting the at least one reaction chamber to the flow channel, a first region adjacent the chamber inlet, a second region spaced from the chamber inlet by the first region, a vent channel and a reaction reagent disposed on at least one inner surface of the second region. Also described is a PCR apparatus and a method of performing PCR.
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公开(公告)号：WO2021262188A1
公开(公告)日：2021-12-30
申请号：PCT/US2020/039763
申请日：2020-06-26
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： CHEN, Chien-Hua , CUMBIE, Michael , WILLIAMS, John L.
Abstract: A fluid-ejection die is provided that has a substrate layer and a device layer at a frontside of the substrate layer. The device layer has a fluid-ejection nozzle and a chamber in which a fluid-ejection element is disposed. The substrate layer has a fluid-feed hole fluidically connected to the chamber. A panel is provided at a backside of the substrate layer. The panel has a fluid-feed slot under the fluid-feed hole. The panel forms the fluid-ejection die along with the substrate layer and the device layer. The substrate layer is backside etched through the fluid-feed slot of the panel to thin the substrate at the thin fluid-feed hole.
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