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    APPARATUS AND METHOD FOR IN VIVO DELIVERY OF THERAPEUTIC AGENTS
    1.
    发明申请
    APPARATUS AND METHOD FOR IN VIVO DELIVERY OF THERAPEUTIC AGENTS 审中-公开
    用于输送治疗药物的装置和方法

    公开(公告)号：WO9922810A9

    公开(公告)日：1999-08-19

    申请号：PCT/US9823649

    申请日：1998-11-04

    Applicant: HISAMITSU PHARMACEUTICAL CO ,  MORI KENJI ,  NOZAWA IWAO ,  SATO SHUJI

    Inventor： MORI KENJI ,  NOZAWA IWAO ,  SATO SHUJI

    IPC: A61N1/30 ,  A61N1/32

    CPC classification number: A61N1/0424 ,  A61N1/042 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/327

    Abstract: Electroporation electrodes (12, 22) are laminated to a permeable membrane (11, 21) to form an electrode membrane. Such an electrode membrane is useful for a continuous controlled delivery of a therapeutic agent through the skin or mucosa when placed in direct contact with the skin or mucosa, and by application of electric field pulses at specified intervals. An electrode membrane can be assembled such that it incorporates an iontophoretic electrode in the same device. The device can be jointly utilized for electroporation, for iontophoretic drug delivery through the skin, and mucosal membrane.

    Abstract translation: 将电穿孔电极（12,22）层叠到可渗透膜（11,21）上以形成电极膜。 这样的电极膜可用于当与皮肤或粘膜直接接触时通过皮肤或粘膜连续控制递送治疗剂，并且以规定的间隔施加电场脉冲。 可以组装电极膜，使得其在同一装置中并入离子电渗电极。 该装置可以共同用于电穿孔，用于通过皮肤的离子电渗药物递送和粘膜。

    Cholesterol-Lowering Drug
    4.
    发明专利
    Cholesterol-Lowering Drug 未知

    公开(公告)号：CA2117371A1

    公开(公告)日：1993-07-22

    申请号：CA2117371

    申请日：1993-01-11

    Applicant: HISAMITSU PHARMACEUTICAL CO

    Inventor： OKAYAMA MINENOBU ,  SATO SHUJI

    IPC: A61K31/785 ,  C08F20/34 ,  C08F120/34

    Abstract: A non-crosslinked anion exchange resin consisting of structural units represented by the general formula (I): wherein R1 represents a benzyl group or an alkyl group having 1 to 20 carbon atoms, R2 and R3 may be identical or different and each represent a lower alkyl group having 1 to 4 carbon atoms, R4 represents a hydrogen atom or a lower alkyl group, X represents a physiologically acceptable counter ion, n is an integer of from 1 to 3, and p is an average degree of polymerization ranging from 10 to 10,000; and a pharmaceutical composition comprising said non-crosslinked anion exchange resin.

    6.
    发明专利
    未知

    公开(公告)号：ES2149537T3

    公开(公告)日：2000-11-01

    申请号：ES97119915

    申请日：1993-01-11

    Applicant: HISAMITSU PHARMACEUTICAL CO

    Inventor： OKAYAMA MINENOBU ,  SATO SHUJI

    IPC: A61K31/785 ,  C08F20/34 ,  C08F120/34

    Abstract: A non-crosslinked anion exchange resin consisting of structural units represented by the general formula (I): wherein R1 represents a benzyl group or an alkyl group having 1 to 20 carbon atoms, R2 and R3 may be identical or different and each represent a lower alkyl group having 1 to 4 carbon atoms, R4 represents a hydrogen atom or a lower alkyl group, X represents a physiologically acceptable counter ion, n is an integer of from 1 to 3, and p is an average degree of polymerization ranging from 10 to 10,000; and a pharmaceutical composition comprising said non-crosslinked anion exchange resin.

    7.
    发明专利
    未知

    公开(公告)号：PT835888E

    公开(公告)日：2000-09-29

    申请号：PT97119915

    申请日：1993-01-11

    Applicant: HISAMITSU PHARMACEUTICAL CO

    Inventor： OKAYAMA MINENOBU ,  SATO SHUJI

    IPC: A61K31/785 ,  C08F20/34 ,  C08F120/34

    Abstract: A non-crosslinked anion exchange resin consisting of structural units represented by the general formula (I): wherein R1 represents a benzyl group or an alkyl group having 1 to 20 carbon atoms, R2 and R3 may be identical or different and each represent a lower alkyl group having 1 to 4 carbon atoms, R4 represents a hydrogen atom or a lower alkyl group, X represents a physiologically acceptable counter ion, n is an integer of from 1 to 3, and p is an average degree of polymerization ranging from 10 to 10,000; and a pharmaceutical composition comprising said non-crosslinked anion exchange resin.

    8.
    发明专利
    未知

    公开(公告)号：DE69328741T2

    公开(公告)日：2000-09-07

    申请号：DE69328741

    申请日：1993-01-11

    Applicant: HISAMITSU PHARMACEUTICAL CO

    Inventor： OKAYAMA MINENOBU ,  SATO SHUJI

    IPC: A61K31/785 ,  C08F20/34 ,  C08F120/34

    Abstract: A non-crosslinked anion exchange resin consisting of structural units represented by the general formula (I): wherein R1 represents a benzyl group or an alkyl group having 1 to 20 carbon atoms, R2 and R3 may be identical or different and each represent a lower alkyl group having 1 to 4 carbon atoms, R4 represents a hydrogen atom or a lower alkyl group, X represents a physiologically acceptable counter ion, n is an integer of from 1 to 3, and p is an average degree of polymerization ranging from 10 to 10,000; and a pharmaceutical composition comprising said non-crosslinked anion exchange resin.

    9.
    发明专利
    未知

    公开(公告)号：AT193307T

    公开(公告)日：2000-06-15

    申请号：AT97119915

    申请日：1993-01-11

    Applicant: HISAMITSU PHARMACEUTICAL CO

    Inventor： OKAYAMA MINENOBU ,  SATO SHUJI

    IPC: A61K31/785 ,  C08F20/34 ,  C08F120/34

    Abstract: A non-crosslinked anion exchange resin consisting of structural units represented by the general formula (I): wherein R1 represents a benzyl group or an alkyl group having 1 to 20 carbon atoms, R2 and R3 may be identical or different and each represent a lower alkyl group having 1 to 4 carbon atoms, R4 represents a hydrogen atom or a lower alkyl group, X represents a physiologically acceptable counter ion, n is an integer of from 1 to 3, and p is an average degree of polymerization ranging from 10 to 10,000; and a pharmaceutical composition comprising said non-crosslinked anion exchange resin.

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