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公开(公告)号：JPH08208750A
公开(公告)日：1996-08-13
申请号：JP31706695
申请日：1995-11-13
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： OKAYAMA MINENOBU , SATO HIDEJI
IPC: A61K31/785 , A61P3/06 , B01J41/14 , C08F20/34
Abstract: PURPOSE: To obtain a non-cross-linked anion exchange resin used as a cholesterol lowering agent reduced in side effects such as the feeling of abdominal inflation and obstipation, freed from conventional drawbacks that it absorbs fat-soluble vitamins and that the difficulty in taking it is considerably large, freed from the inconvenience that it must be suspended when it is taken and being easily taken in the form of tablets, granules, capsules, or the like. CONSTITUTION: An anion exchange resin comprising repeating units of the formula [wherein R1 is benzyl or 1-20 C alkyl; R2 and R3 are the same or different from each other and each 1-4 C lower alkyl; R4 is hydrogen or lower alkyl group. X is a physiologically acceptable counter ion; n is 1-3; and p is the average degree of polymerization and is 10-10000].
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公开(公告)号：ES2163453T3
公开(公告)日：2002-02-01
申请号：ES94927785
申请日：1994-09-28
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： OKAYAMA MINENOBU , SUZUKI YOSUKE , WADA AKIRA
Abstract: A polyamino acid oligonucleotide carrier comprising a poly(lysine-serine) random copolymer. The carrier combines with an oligonucleotide without causing precipitation and releases the combined oligonucleotide smoothly in a cell. Hence it is useful as a carrier for in vivo transportation of a drug for oligonucleotide gene therapy against various types of genopathy and viral diseases such as AIDS. Further it contributes greatly to the creation of various useful animals and plants, such as virus-resistant plants, by genetic engineering techniques.
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公开(公告)号：CA2117371A1
公开(公告)日：1993-07-22
申请号：CA2117371
申请日：1993-01-11
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： OKAYAMA MINENOBU , SATO SHUJI
IPC: A61K31/785 , C08F20/34 , C08F120/34
Abstract: A non-crosslinked anion exchange resin consisting of structural units represented by the general formula (I): wherein R1 represents a benzyl group or an alkyl group having 1 to 20 carbon atoms, R2 and R3 may be identical or different and each represent a lower alkyl group having 1 to 4 carbon atoms, R4 represents a hydrogen atom or a lower alkyl group, X represents a physiologically acceptable counter ion, n is an integer of from 1 to 3, and p is an average degree of polymerization ranging from 10 to 10,000; and a pharmaceutical composition comprising said non-crosslinked anion exchange resin.
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公开(公告)号：DE69332082D1
公开(公告)日：2002-08-08
申请号：DE69332082
申请日：1993-11-05
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： OKAYAMA MINENOBU , NAKANISHI MASARU
Abstract: A peroral pharmaceutical preparation releasable in the lower digestive tract, having a double-layer coating structure wherein a solid drug comprising a core containing an active ingredient is coated with an inner layer comprising a cationic polymer and an outer layer comprising an anionic polymer.
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公开(公告)号：GR3034214T3
公开(公告)日：2000-12-29
申请号：GR20000401899
申请日：2000-08-17
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： OKAYAMA MINENOBU , SATO SHUJI
IPC: A61K31/785 , C08F20/34 , C08F120/34
Abstract: A non-crosslinked anion exchange resin consisting of structural units represented by the general formula (I): wherein R1 represents a benzyl group or an alkyl group having 1 to 20 carbon atoms, R2 and R3 may be identical or different and each represent a lower alkyl group having 1 to 4 carbon atoms, R4 represents a hydrogen atom or a lower alkyl group, X represents a physiologically acceptable counter ion, n is an integer of from 1 to 3, and p is an average degree of polymerization ranging from 10 to 10,000; and a pharmaceutical composition comprising said non-crosslinked anion exchange resin.
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Patent Agency Ranking
公开(公告)号：AU5376894A
公开(公告)日：1994-06-08
申请号：AU5376894
申请日：1993-11-05
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： OKAYAMA MINENOBU , NAKANISHI MASARU
Abstract: A peroral pharmaceutical preparation releasable in the lower digestive tract, having a double-layer coating structure wherein a solid drug comprising a core containing an active ingredient is coated with an inner layer comprising a cationic polymer and an outer layer comprising an anionic polymer.
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公开(公告)号：AT209506T
公开(公告)日：2001-12-15
申请号：AT94927785
申请日：1994-09-28
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： OKAYAMA MINENOBU , SUZUKI YOSUKE , WADA AKIRA
Abstract: A polyamino acid oligonucleotide carrier comprising a poly(lysine-serine) random copolymer. The carrier combines with an oligonucleotide without causing precipitation and releases the combined oligonucleotide smoothly in a cell. Hence it is useful as a carrier for in vivo transportation of a drug for oligonucleotide gene therapy against various types of genopathy and viral diseases such as AIDS. Further it contributes greatly to the creation of various useful animals and plants, such as virus-resistant plants, by genetic engineering techniques.
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公开(公告)号：DK0835888T3
公开(公告)日：2000-09-25
申请号：DK97119915
申请日：1993-01-11
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： OKAYAMA MINENOBU , SATO SHUJI
IPC: A61K31/785 , C08F20/34 , C08F120/34
Abstract: A non-crosslinked anion exchange resin consisting of structural units represented by the general formula (I): wherein R1 represents a benzyl group or an alkyl group having 1 to 20 carbon atoms, R2 and R3 may be identical or different and each represent a lower alkyl group having 1 to 4 carbon atoms, R4 represents a hydrogen atom or a lower alkyl group, X represents a physiologically acceptable counter ion, n is an integer of from 1 to 3, and p is an average degree of polymerization ranging from 10 to 10,000; and a pharmaceutical composition comprising said non-crosslinked anion exchange resin.
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公开(公告)号：DE69328741D1
公开(公告)日：2000-06-29
申请号：DE69328741
申请日：1993-01-11
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： OKAYAMA MINENOBU , SATO SHUJI
IPC: A61K31/785 , C08F20/34 , C08F120/34
Abstract: A non-crosslinked anion exchange resin consisting of structural units represented by the general formula (I): wherein R1 represents a benzyl group or an alkyl group having 1 to 20 carbon atoms, R2 and R3 may be identical or different and each represent a lower alkyl group having 1 to 4 carbon atoms, R4 represents a hydrogen atom or a lower alkyl group, X represents a physiologically acceptable counter ion, n is an integer of from 1 to 3, and p is an average degree of polymerization ranging from 10 to 10,000; and a pharmaceutical composition comprising said non-crosslinked anion exchange resin.
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公开(公告)号：AU681192B2
公开(公告)日：1997-08-21
申请号：AU7706994
申请日：1994-09-28
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： OKAYAMA MINENOBU , SUZUKI YOSUKE , WADA AKIRA
Abstract: A polyamino acid oligonucleotide carrier comprising a poly(lysine-serine) random copolymer. The carrier combines with an oligonucleotide without causing precipitation and releases the combined oligonucleotide smoothly in a cell. Hence it is useful as a carrier for in vivo transportation of a drug for oligonucleotide gene therapy against various types of genopathy and viral diseases such as AIDS. Further it contributes greatly to the creation of various useful animals and plants, such as virus-resistant plants, by genetic engineering techniques.
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