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    PROCESS FOR PREPARING 6,11-DIHYDRO-11-OXODIBENZ(B,E)OXEPIN ALKANOIC ACIDS AND ESTERS THEREOF
    1.
    发明授权
    PROCESS FOR PREPARING 6,11-DIHYDRO-11-OXODIBENZ(B,E)OXEPIN ALKANOIC ACIDS AND ESTERS THEREOF 失效

    公开(公告)号：KR790001066B1

    公开(公告)日：1979-08-24

    申请号：KR750002624

    申请日：1975-12-01

    Applicant: HOECHST AG

    Inventor： MCFADDEN A R ,  AULTZ D E

    Abstract: Title compd. (I; R = H or C1-4 alkyl, R1 = H, halogen, C1-4 alkoxy, C1-14 alkyl or acidic fluoromethyl, n = 1-3) and its ester, having good antiinflammatory activity, was prepd. Thus, alkyl ester (II) and hydroxypheny lacetic alkyl ester (III) was reacted to obtain diester(IV) in the presence of solvent or acid acceptor at 0-120≦̸C for 5min-20hr, and saponificated, cyclized, or reacted with thionyl halide and phosphorous halide to make 2-acid halide, the reaction product was cyclized by heating at 80-120≦̸C, and hydrolyzed, to giveI.

    PROCESS FOR PREPARING HETEROARYLBENZOXEPIN-ACETICACIDS
    2.
    发明授权
    PROCESS FOR PREPARING HETEROARYLBENZOXEPIN-ACETICACIDS 失效

    公开(公告)号：KR790001067B1

    公开(公告)日：1979-08-24

    申请号：KR750002751

    申请日：1975-12-16

    Applicant: HOECHST AG

    Inventor： MCFADDEN A R ,  AULTZ D E

    Abstract: Title compd., useful as analgesics and inflammation inhibitors(no data), was prepd. Thus, lower alkylester reacted with the lower alkylester of (hydroxy-phenyl) acetic acid to give Ia(X = pentagonal or hexagonal heteroaryl ring contg. 1 or 2 O, N, or S with C, R1 = H or methyl, R2 = H or methyl, n = 1,2,3) and II or III (Y=Br, Cl) was cyclized followed by hydrolysis to give Ib(R = H or C1-5 straighted or branched alkyl).

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