公开(公告)号：DE69419954T2

公开(公告)日：2000-04-13

申请号：DE69419954

申请日：1994-03-24

Applicant: HOECHST AG

Inventor： KURTZ ELLEN SMITH ,  WEITHMANN KLAUS ULRICH ,  BARTLETT ROBERT RYDER

IPC: A61K31/41 ,  A61K31/00 ,  A61K31/275 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4418 ,  A61P17/00 ,  A61P17/06 ,  A61P37/08 ,  C07D213/75 ,  C07D261/18 ,  C07D413/12

Abstract: A compound of the formula I or II and physiologically tolerable salts of compound of the formula II are suitable for treatment of psoriasis.

公开(公告)号：AU696851B2

公开(公告)日：1998-09-17

申请号：AU1015095

申请日：1995-01-11

Applicant: HOECHST AG

Inventor： BARTLETT ROBERT RYDER ,  MORRIS RANDALL E

IPC: C07D213/75 ,  A61K31/275 ,  A61K31/365 ,  A61K31/42 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/70 ,  A61K38/00 ,  A61P9/00 ,  A61P37/06 ,  C07D213/85 ,  C07D261/18 ,  C07D413/12 ,  A61K31/165

公开(公告)号：HUT76481A

公开(公告)日：1997-09-29

申请号：HU9602458

申请日：1995-03-03

Applicant: HOECHST AG

Inventor： ANAGNOSTOPULOS HIRISTO ,  BARTLETT ROBERT RYDER ,  SCHLEYERBACH RUDOLF ,  SCHWAB WILFRIED ,  WEITHMANN KLAUS ULRICH

IPC: A61K31/41 ,  A61K31/42 ,  A61K31/423 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  C07C205/51 ,  C07D261/04 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D263/30 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07F9/653

Abstract: PCT No. PCT/EP95/00784 Sec. 371 Date Nov. 19, 1996 Sec. 102(e) Date Nov. 19, 1996 PCT Filed Mar. 3, 1995 PCT Pub. No. WO95/24397 PCT Pub. Date Sep. 14, 1995A compound having the formula (I), a physiologically tolerable salt of the compound having the formula (I) and/or a steroisomeric form of the compound having the formula (I), in which one residue R1 or R2 stands for the formula (II), are suitable for preparing medicaments for the therapy of inflammations, asthma, rheumatoid diseases and auto-immune diseases.

公开(公告)号：NO963560A

公开(公告)日：1996-08-26

申请号：NO963560

申请日：1996-08-26

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  BARTLETT ROBERT RYDER ,  SCHLEYERBACH RUDOLF ,  WEITHMANN KLAUS ULRICH

IPC: A61K31/41 ,  A61K31/42 ,  A61K31/423 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  C07C205/51 ,  C07D261/04 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D263/30 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07F9/653 ,  C07D

CPC classification number: C07C205/51 ,  C07D261/04 ,  C07D261/08 ,  C07D261/20 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07F9/653

公开(公告)号：HU9300110D0

公开(公告)日：1993-04-28

申请号：HU9300110

申请日：1993-01-15

Applicant: HOECHST AG

Inventor： NAIK RAMACHANDRA GANAPATI ,  MUMBAIKAR VILAS NARAYAN ,  VASUMATHY RANGARAJAN ,  LAKDAWALA AFTAB DAWOODBHAI ,  SHIROLE MANDAKINI VITHALRAO ,  LAL BANSI ,  BLUMBACH JUERGEN ,  WEITHMANN KLAUS ULBRICH ,  BARTLETT ROBERT RYDER

IPC: A61K31/12 ,  A61K31/00 ,  A61K31/121 ,  A61P11/06 ,  A61P19/00 ,  A61P25/04 ,  A61P29/00 ,  A61P35/00 ,  C07C45/67 ,  C07C45/70 ,  C07C45/74 ,  C07C49/796 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07C65/40 ,  C07C69/157 ,  C07C205/45 ,  C07C229/08 ,  C07C233/33 ,  C07C255/56 ,  C07D207/33 ,  C07D213/24 ,  C07D213/38 ,  C07D307/46 ,  C07D307/52 ,  C07D317/54 ,  C07D333/20 ,  C07D333/22

Abstract: Compounds of formula I, wherein the substituents R1 - R4 and a have the given meaning show an activity against inflammatory conditions.

公开(公告)号：DK592988D0

公开(公告)日：1988-10-25

申请号：DK592988

申请日：1988-10-25

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  BARTLETT ROBERT RYDER ,  GEBERT ULRICH ,  SCHORLEMMER HANS ULRICH ,  DICKNEITE GERHARD ,  SEDLACEK HANS HARALD

IPC: A61K31/675 ,  A61K39/39 ,  A61P35/00 ,  A61P37/00 ,  C07F9/40 ,  C07F9/547 ,  C07F9/653 ,  C07F9/6574 ,  C07F9/65

Abstract: The medicine contains or consists of at least one compound of the formula I and/or optionally one of its physiologically tolerated salts, where the compounds of the formula I can optionally be in the form of pure stereoisomers or mixtures thereof; formula I is: in which R = organic radical or halogen A = C,C single or C,C double bond, n = 0, 1 or 2 and X and Y = alkyl radical or = -OR or -NR R with R , R = H or optionally substituted aliphatic radical. The medicines are suitable for the prophylaxis and/or treatment of disorders of the immune system.

公开(公告)号：DK0749429T3

公开(公告)日：2000-01-10

申请号：DK95912197

申请日：1995-03-03

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  BARTLETT ROBERT RYDER ,  SCHLEYERBACH RUDOLF ,  WEITHMANN KLAUS ULRICH

IPC: A61K31/41 ,  A61K31/42 ,  A61K31/423 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  C07C205/51 ,  C07D261/04 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D263/30 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07F9/653

Abstract: PCT No. PCT/EP95/00784 Sec. 371 Date Nov. 19, 1996 Sec. 102(e) Date Nov. 19, 1996 PCT Filed Mar. 3, 1995 PCT Pub. No. WO95/24397 PCT Pub. Date Sep. 14, 1995A compound having the formula (I), a physiologically tolerable salt of the compound having the formula (I) and/or a steroisomeric form of the compound having the formula (I), in which one residue R1 or R2 stands for the formula (II), are suitable for preparing medicaments for the therapy of inflammations, asthma, rheumatoid diseases and auto-immune diseases.

公开(公告)号：FI963508A0

公开(公告)日：1996-09-06

申请号：FI963508

申请日：1996-09-06

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  BARTLETT ROBERT RYDER ,  SCHLEYERBACH RUDOLF ,  WEITHMANN KLAUS ULRICH

IPC: A61K31/41 ,  A61K31/42 ,  A61K31/423 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  C07C205/51 ,  C07D261/04 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D263/30 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07F9/653 ,  C07D

Abstract: PCT No. PCT/EP95/00784 Sec. 371 Date Nov. 19, 1996 Sec. 102(e) Date Nov. 19, 1996 PCT Filed Mar. 3, 1995 PCT Pub. No. WO95/24397 PCT Pub. Date Sep. 14, 1995A compound having the formula (I), a physiologically tolerable salt of the compound having the formula (I) and/or a steroisomeric form of the compound having the formula (I), in which one residue R1 or R2 stands for the formula (II), are suitable for preparing medicaments for the therapy of inflammations, asthma, rheumatoid diseases and auto-immune diseases.

公开(公告)号：NO178922C

公开(公告)日：1996-07-03

申请号：NO924093

申请日：1992-10-22

Applicant: HOECHST AG

Inventor： SCHLEYERBACH RUDOLF ,  BARTLETT ROBERT RYDER ,  KUO ELIZABETH ANNE ,  LITTLE EWARD JAMES

IPC: A61K31/16 ,  A61K31/275 ,  C07C255/30 ,  A61K31/277 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  C07C253/00 ,  C07C255/20 ,  C07C255/21 ,  C07C255/23 ,  C07C255/27 ,  C07C323/36

Abstract: The use of N-phenyl-2-cyano-3-hydroxycrotonamide derivatives of the formula I where R is hydrogen atom or (C1-C4)-alkyl, R is CN, CX3, WCX3, W(CH2)nCX3, NO2, (CH2)nCX3, halogen, in which X is halogen, W is oxygen or sulphur atom and n is an integer from 1 to 3, R is (C1-C4)-alkyl, (C3-C6)-cycloalkyl, CN or -CO-R in which R is (C1-C4)-alkyl or (C3-C6)-cycloalkyl, and/or the physiologically tolerated salts thereof, for the treatment of rheumatic disorders, autoimmune diseases and of rejection reactions against the transplanted organ in an organ recipient, is described.

公开(公告)号：HUT70757A

公开(公告)日：1995-10-30

申请号：HU9400908

申请日：1994-03-30

Applicant: HOECHST AG

Inventor： BARTLETT ROBERT RYDER ,  WEITHMANN KLAUS ULRICH ,  KURTZ ELLEN SMITH

IPC: A61K31/00 ,  A61K31/275 ,  A61K31/42 ,  A61K31/41 ,  A61K31/44 ,  A61K31/4418 ,  A61P17/00 ,  A61P17/06 ,  A61P37/08 ,  C07D213/75 ,  C07D261/18 ,  C07D413/12

Abstract: A compound of the formula I or II and physiologically tolerable salts of compound of the formula II are suitable for treatment of psoriasis.