公开(公告)号：DE59608740D1

公开(公告)日：2002-03-21

申请号：DE59608740

申请日：1996-11-04

Applicant: HOECHST AG

Inventor： THORWART WERNER ,  SCHWAB WILFRIED ,  SCHUDOK MANFRED ,  HAASE BURKHARD ,  BARTNIK ECKART ,  WEITHMANN KLAUS-ULRICH

IPC: A61K31/00 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4725 ,  A61P43/00 ,  C07D209/42 ,  C07D217/26 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/056

Abstract: Cyclic and heterocyclic N-substituted alpha-iminohydroxamic and -carboxylic acidsCompounds of the formula Iare suitable for preparing pharmaceuticals for the treatment of disorders in the course of which is involved an increased activity of matrix-degrading metalloproteinases.

公开(公告)号：HU9801045A2

公开(公告)日：1999-06-28

申请号：HU9801045

申请日：1998-05-08

Applicant: HOECHST AG

Inventor： BILLEN GUENTER ,  HAASE BURKHARD ,  NEISES BERNHARD ,  SCHUDOK MANFRED ,  SCHWAB WILFRIED ,  THORWART WERNER

IPC: C07D295/18 ,  A61K31/195 ,  A61K31/215 ,  A61K31/27 ,  A61K31/275 ,  A61K31/33 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/48 ,  A61K31/535 ,  A61K31/5355 ,  A61K31/5375 ,  A61K31/5377 ,  A61P1/02 ,  A61P9/10 ,  A61P19/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07C311/13 ,  C07C311/19 ,  C07C311/22 ,  C07C311/29 ,  C07C323/59 ,  C07D207/16 ,  C07D207/34 ,  C07D207/38 ,  C07D209/46 ,  C07D209/48 ,  C07D213/81 ,  C07D213/82 ,  C07D215/14 ,  C07D233/54 ,  C07D233/61 ,  C07D233/64 ,  C07D233/74 ,  C07D235/08 ,  C07D235/24 ,  C07D241/24 ,  C07D249/08 ,  C07D249/12 ,  C07D261/10 ,  C07D261/18 ,  C07D275/04 ,  C07D277/06 ,  C07D277/28 ,  C07D307/24 ,  C07D307/54 ,  C07D307/58 ,  C07D307/68 ,  C07D333/22 ,  C07D333/24 ,  C07D333/38 ,  C07D401/12 ,  C07D513/04 ,  C07C311/18

Abstract: Phenyl-, thienyl- or furanyl-substituted N( alpha )-sulphonyl-diaminocarboxylic acid derivatives of formula (I) and their stereoisomers and salts are new. R1 = Ar or Het; Ar = phenyl (optionally substituted by 1 or 2 of 1-7C alkyl, 3-7C cycloalkyl, OH, alkyl-COO-, alkyl-O-, alkyl-O-(1-4C alkylene)-O-, halo, CF3, CN, NO2, COOH, alkyl-O-CO-, OCH2O, NR4R5CO and NR4R5); Het = pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thienyl, thiazolyl, oxazolyl, isoxazolyl, pyridinyl, pyrimidinyl, indolyl, benzothiophenyl, benzimidazolyl, benzoxazolyl, benzothiazolyl or benzotriazolyl (all optionally substituted as for phenyl in Ar); R2,R4,R5 = H, alkyl, carboxyalkyl, Ar-(CH2)o- or picolyl; or NR4R5 = 4-7 membered ring, optionally having one C replaced by O, S or NH; o = 0-2; R3,G = H, alkyl, 3-6C cycloalkyl, 2-6C alkenyl, Ar-(CH2)m-, Het-(CH2)m-, R6CO-, R6OCO-, R6CH(NH2)CO-, NR7R8CO-, R6SO2-, R6SO2NR7CO-. R'6-NHC(=NR'7)- or a heterocyclic group of formula (i); or N(G)R3 = succinimido, maleimido, 2-oxo-pyrrolidino, 1H-1-pyrrolyl, 1H-1-imidazolyl or 2-oxo-2,3-dihydro-1H-1-pyrrolyl, all monosubstituted by R7; phthalimido or 2-oxo-1-indolinyl, both monosubstituted by R10 in the benzene ring; 1-indolyl; 1-benzimidazolyl; pyrrolidino, piperidino, perhydroazepino or perhydroazocino; or a group of formula (ii)-(vi); one ring C in (iv) is optionally replaced by O, S, SO2 or NR2; m = 0-3; r = 1 or 2; R6 = H, alkyl (optionally substituted as for Ar or by 3-6C cycloalkyl), 3-6C cycloalkyl (optionally substituted as for Ar), 2-6C alkenyl (optionally substituted as for Ar, or by Ar or Het (both optionally having a third substituent as above)); Ar-(CH2)m (in which Ar optionally has a third substituent as above and may further be substituted by OCF3, SO2NH2, NHCOCF3 or benzyl; and (CH2)m is optionally substituted by COOH), naphthyl, adamantyl or Het-(CH2)m-; R7 = H or alkyl; R8 = H, alkyl, Ar-(CH2)m- or Het-(CH2)m-; or NR7R8 = optionally substituted 4-7 membered ring, optionally having one C replaced by O, S or NH; R'6,R'7 = as R6,R7; or alkyl-CO-, NO2 or Ar-(CH2)m-SO2-; W = N, S or O; R10 = one or the optional substituents of Ar; A = direct bond, O, CH=CH or C IDENTICAL C; B = (CH2)m, O(CH2)q or CH=CH; q = 1-5; D = (CH2)s, optionally with one C replaced by optionally substituted NH, O or S; s = 1-6; X = CH=CH, O or S; R9 = H; or can also be alkyl, phenyl, succinimidyl, benzotriazolyl or benzyl if G = H; unless specified otherwise alkyl moieties have 1-6C.

公开(公告)号：CA2228060A1

公开(公告)日：1998-07-28

申请号：CA2228060

申请日：1998-01-26

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  KIRSCHBAUM BERND ,  MULLNER STEFAN

IPC: B01J20/281 ,  A61K31/167 ,  A61K31/275 ,  A61K31/42 ,  A61K39/385 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C233/58 ,  C07C235/28 ,  C07C235/74 ,  C07C237/04 ,  C07C255/23 ,  C07C255/30 ,  C07D261/08 ,  C07D261/18 ,  G01N30/88 ,  G01N33/53 ,  G01N33/543 ,  G01N33/558 ,  G01N33/68 ,  G01N33/94 ,  A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  C07C279/14 ,  C07C323/60 ,  C07D207/16 ,  C07D209/20 ,  C07D233/64 ,  C07D413/12 ,  C07K1/22 ,  G01N30/48

Abstract: Isoxazole and crotonamide derivatives and their use as pharmaceuticals and diagnostics A compound of the formula (see fig. I) , where R1 is the radical of the formula II or III (see fig. II) (see fig. III) is suitable for the production of a pharmaceutical for the treatment of inflamma tions, carcinomatous diseases or autoimmune diseases. A compound of the formula IV (see fig. IV), is suitable for the production of specific antibodies against a compound of the formula I for the discovery of specific-binding proteins from cell extracts, ser um, blood or synovial fluids, for the purification of proteins, for the modification of microtiter plates or for the preparation of chromatography material, in particul ar of affinity chromatography material, and for use in diagnostics.

公开(公告)号：CA2214670A1

公开(公告)日：1998-03-12

申请号：CA2214670

申请日：1997-09-04

Applicant: HOECHST AG

Inventor： RAISS RUTH ,  SCHWAB WILFRIED

IPC: A61K31/275 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/52 ,  A61K31/522 ,  A61P1/02 ,  A61P3/00 ,  A61P29/00 ,  C07C7/00 ,  C07C255/20 ,  C07C255/23 ,  C07C255/41 ,  C07C255/57 ,  C07C255/59 ,  C07C323/41 ,  C07D213/56 ,  C07D213/57 ,  C07D307/42 ,  C07D307/54 ,  C07D317/60 ,  C07D333/24 ,  C07D333/26 ,  C07D473/04 ,  C07D473/06 ,  C07C255/44 ,  C07D275/02 ,  C07D261/08 ,  C07D239/26 ,  C07C253/30 ,  C07D277/30 ,  C07D263/32 ,  A61K31/33 ,  C07D207/337 ,  C07C255/60

Abstract: 2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives (see fig.I) are suitable for the production of pharmaceuticals for the prophylaxis and thera py of diseases or disorders whose course involves increased connective tissue or cartilage degradation.

公开(公告)号：HUT76481A

公开(公告)日：1997-09-29

申请号：HU9602458

申请日：1995-03-03

Applicant: HOECHST AG

Inventor： ANAGNOSTOPULOS HIRISTO ,  BARTLETT ROBERT RYDER ,  SCHLEYERBACH RUDOLF ,  SCHWAB WILFRIED ,  WEITHMANN KLAUS ULRICH

IPC: A61K31/41 ,  A61K31/42 ,  A61K31/423 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  C07C205/51 ,  C07D261/04 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D263/30 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07F9/653

Abstract: PCT No. PCT/EP95/00784 Sec. 371 Date Nov. 19, 1996 Sec. 102(e) Date Nov. 19, 1996 PCT Filed Mar. 3, 1995 PCT Pub. No. WO95/24397 PCT Pub. Date Sep. 14, 1995A compound having the formula (I), a physiologically tolerable salt of the compound having the formula (I) and/or a steroisomeric form of the compound having the formula (I), in which one residue R1 or R2 stands for the formula (II), are suitable for preparing medicaments for the therapy of inflammations, asthma, rheumatoid diseases and auto-immune diseases.

公开(公告)号：AU7562496A

公开(公告)日：1997-06-05

申请号：AU7562496

申请日：1996-11-04

Applicant: HOECHST AG

Inventor： THORWART WERNER ,  SCHWAB WILFRIED ,  SCHUDOK MANFRED ,  HAASE BURKHARD ,  BARTNIK ECKART ,  WEITHMANN KLAUS-ULRICH

IPC: A61K31/00 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4725 ,  A61P43/00 ,  C07D209/42 ,  C07D217/26 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/056 ,  C07D221/16 ,  A61K31/40

Abstract: Cyclic and heterocyclic N-substituted alpha-iminohydroxamic and -carboxylic acidsCompounds of the formula Iare suitable for preparing pharmaceuticals for the treatment of disorders in the course of which is involved an increased activity of matrix-degrading metalloproteinases.

公开(公告)号：NO963560A

公开(公告)日：1996-08-26

申请号：NO963560

申请日：1996-08-26

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  BARTLETT ROBERT RYDER ,  SCHLEYERBACH RUDOLF ,  WEITHMANN KLAUS ULRICH

IPC: A61K31/41 ,  A61K31/42 ,  A61K31/423 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  C07C205/51 ,  C07D261/04 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D263/30 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07F9/653 ,  C07D

CPC classification number: C07C205/51 ,  C07D261/04 ,  C07D261/08 ,  C07D261/20 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07F9/653

公开(公告)号：MX168599B

公开(公告)日：1993-06-01

申请号：MX799984

申请日：1984-05-04

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  SCHWAB WILFRIED ,  DURCKHEIMER WALTER ,  KIRRSTETTER REINER

IPC: C07D501/04 ,  A61K31/425 ,  A61K31/545 ,  C07D20060101 ,  C07D501/00 ,  C07D501/06 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/57

Abstract: Process for the preparation of cephem compounds of the formula

公开(公告)号：HUT61649A

公开(公告)日：1993-03-01

申请号：HU171192

申请日：1990-11-17

Applicant: HOECHST AG

Inventor： LOEHER HEINZ-JOSEF ,  SCHWAB WILFRIED ,  BAUER KLAUS ,  BIERINGER HERMANN

IPC: A01N25/32 ,  A01N55/10 ,  C07D261/04

公开(公告)号：PT97329A

公开(公告)日：1992-01-31

申请号：PT9732991

申请日：1991-04-11

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  ANAGNOSTOPULOS HIRISTO ,  PORSCHE-WIEBKING ELENA ,  GROME JOHN

IPC: A61K31/415 ,  A61K31/44 ,  A61K31/445 ,  A61K31/675 ,  A61P9/10 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  C07D261/04 ,  C07D261/08 ,  C07D261/12 ,  C07D261/18 ,  C07D413/04 ,  C07D413/06 ,  C07F9/653 ,  C07D261/00 ,  C07D413/00 ,  A61K31/42

Abstract: Novel 3,5-disubstituted 2-isoxazolines and isoxazoles and novel pharmaceuticals are described which are suitable, in particular, for the prophylaxis and/or treatment of pathological, neurodegenerative disorders in humans and animals. Processes for the preparation of these 3,5-disubstituted 2-isoxazolines and isoxazolines and isoxazoles are additionally indicated.