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    1-HYDROXY-CYTORHODINES, A MICROBIOLOGICAL METHOD FOR THEIR PREPARATION AND THEIR USE AS CYTOSTATIC AGENTS
    3.
    发明专利
    1-HYDROXY-CYTORHODINES, A MICROBIOLOGICAL METHOD FOR THEIR PREPARATION AND THEIR USE AS CYTOSTATIC AGENTS 未知

    公开(公告)号：DE3573263D1

    公开(公告)日：1989-11-02

    申请号：DE3573263

    申请日：1985-07-01

    Applicant: HOECHST AG

    Inventor： ARETZ WERNER DR ,  BERSCHEID HANS GERD DR ,  FEHLHABER HANS-WOLFRAM DR ,  BOTTGER DIRK DR ,  KRAEMER HANS PETER DR

    IPC: C07C50/36 ,  A61K31/12 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07C45/00 ,  C07C67/00 ,  C07H15/252 ,  C12P7/26 ,  C12P19/56 ,  C12R1/465

    Abstract: 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.

    7.
    发明专利
    未知

    公开(公告)号：DE3425357A1

    公开(公告)日：1986-01-23

    申请号：DE3425357

    申请日：1984-07-10

    Applicant: HOECHST AG

    Inventor： ARETZ WERNER DR ,  BERSCHEID HANS GERD DR ,  FEHLHABER HANS-WOLFRAM DR ,  BOETTGER DIRK DR ,  KRAEMER HANS PETER DR RER NAT

    IPC: C07C50/36 ,  A61K31/12 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07C45/00 ,  C07C67/00 ,  C07H15/252 ,  C12P7/26 ,  C12P19/56 ,  C12R1/465 ,  C07H15/24 ,  A61K31/65 ,  A61K31/71 ,  C12P29/00 ,  C12P19/44

    Abstract: 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.

    8.
    发明专利
    未知

    公开(公告)号：GR851003B

    公开(公告)日：1985-11-25

    申请号：GR850101003

    申请日：1985-04-25

    Applicant: HOECHST AG

    Inventor： ARETZ WERNER DR ,  BERSCHEID HANS GERD DR ,  FEHLABER HANS-WOLFRAM DR ,  HUBER GERHARD DR ,  KRAEMER HANS PETER DR

    IPC: C07H15/252

    Abstract: The present application relates to a microbiological process for the preparation of compounds of the formula I in which R1 and R2 are identical or different and each represent combinations of three sugar molecules, using a specific oxidoreductase. The compounds which can be prepared according to the invention have cytostatic activity and can be used as pharmaceuticals.

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